About: MicroRNA profiling in paired left and right eyes, lungs, and testes of normal mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MicroRNA profiling in paired left and right eyes, lungs, and testes of normal mice
Creator	Cui, Qinghua Zhou, Yuan Cui, Chunmei Hu, Chengqing Shi, Jiangcheng Yang, Jichun
Source	Elsevier; Medline; PMC
abstract	Abstract Physiological and pathophysiological differences widely exist in paired organ systems. However, the molecular basis for these differences remain largely unknown. We previously reported that there exist differentially expressed miRNAs (DEMs) in the left and right kidneys of normal mice. Here, we identified the DEMs in the left and right eyes, lungs and testes of normal mice via RNA Sequencing. As a result, we identified 26 DEMs in eyes, with 23 higher and 3 lower in the left eyes compared with right eyes, 21 DEMs in lungs, with 15 higher and 6 lower in the left lungs compared with right lungs; and 54 DEMs in testes, with 6 higher and 48 lower in the left testes compared with right ones. Ten miRNAs were further examined by quantitative PCR assays, and seven of these were confirmed. In addition, correlation analysis was performed between paired organ miRNA expressions and diverse body fluid miRNA expressions. Finally, we explored the functions and networks of DEMs and performed biological process and pathway enrichment analysis of target genes for DEMs, providing insights into the physiological and pathophysiological differences between the two entities of paired organs.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.1016/j.omtn.2020.07.006
bibo:pmid	32769059
has license	els-covid
sha1sum (hex)	d83ac4a788c6a2b21202af1f56d3ceffde0d22b6
schema:url	https://doi.org/10.1016/j.omtn.2020.07.006
resource representing a document's title	MicroRNA profiling in paired left and right eyes, lungs, and testes of normal mice
has PubMed Central identifier	PMC7347495
has PubMed identifier	32769059
schema:publication	Mol Ther Nucleic Acids
resource representing a document's body	covid:d83ac4a788c6a2b21202af1f56d3ceffde0d22b6#body_text
is schema:about of	named entity 'MicroRNA' named entity 'testes' named entity 'MicroRNA' named entity 'MicroRNA' named entity 'lungs' named entity 'doi' named entity 'lungs' named entity 'mice' named entity 'miRNAs' named entity 'lungs' named entity 'testes' named entity 'miRNAs' named entity 'tumor suppressor' named entity 'mice' named entity 'miRNAs' named entity 'lungs' named entity 'miRNAs' named entity 'significant difference' named entity 'randomly selected' named entity 'invertebrate animals' named entity 'miRNAs' named entity 'organ systems' named entity 'Wuhan' named entity 'evolutionary conservation' named entity 'miRNAs' named entity 'RNA-Seq' named entity 'testes' named entity 'miRNAs' named entity 'lung' named entity 'PCR analysis' named entity 'vertebrate' named entity 'real-time PCR' named entity 'testes' named entity 'testes' named entity 'autosomes' named entity 'morbidity' named entity 'adipocyte' named entity 'miRNAs' named entity 'cell death' named entity 'DEMs' named entity 'anatomical structure' named entity 'real-time PCR' named entity 'paired organs' named entity 'miRNAs' named entity 'miRNAs' named entity 'miRNAs' named entity 'RNA-Seq' named entity 'Beijing' named entity 'lungs' named entity 'S1C' named entity 'miRNA' named entity 'expression levels' named entity 'China' named entity 'lungs' named entity 'immune response' named entity '2A-C' named entity 'Differentially expressed' named entity 'mammal' named entity 'RNA' named entity 'lungs' named entity 'real-time PCR' named entity 'China' named entity 'miRNAs' named entity 'DEMs' named entity 'significant difference' named entity 'paired organs' named entity 'testicular cancer' named entity 'DEMs' named entity 'miRNAs' named entity 'neural stem cell' named entity 'testes' named entity 'testes' named entity 'miR' named entity 'tumor suppressor' named entity 'BGI' named entity 'autosomes'

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