About: Cardiac Structural and Functional Characteristics in Patients with Coronavirus Disease 2019: A Serial Echocardiographic Study

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About: Cardiac Structural and Functional Characteristics in Patients with Coronavirus Disease 2019: A Serial Echocardiographic Study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cardiac Structural and Functional Characteristics in Patients with Coronavirus Disease 2019: A Serial Echocardiographic Study
Creator	Jiang, ; Li, ; Wang, ; Zhang, ; Zhu, ; Du, ; Du, Jing Gu Zhichun, ; Handong, Heng, G Jun, P Mingli, Pu, ; Qiao, ; Zhou, 1#
Source	MedRxiv
abstract	BACKGROUND: Increasing attention has been paid to cardiac involvement in patients with coronavirus disease 2019 (COVID-19). Yet, scarce information is available regarding the morphological and functional features of cardiac impairments in these patients. METHODS: We conducted a prospective and serial echocardiographic study to investigate the structural and functional cardiac changes among COVID-19 patients admitted to the intensive care unit (ICU). From January 21 to April 8, 2020, a total of 51 ICU patients (31 critically ill and 20 severely ill) with confirmed COVID-19 were monitored by serial transthoracic echocardiography examinations. Outcomes were followed up until April 8, 2020. RESULTS: Of 51 ICU patients, 33 (64.7%) had cardiovascular comorbidities. Elevations of levels of cardiac biomarkers including high-sensitivity cardiac troponin-I (hs-cTnI) and brain natriuretic peptide were observed in 62.7% and 86.3% of patients, respectively. Forty-two (82.3%) had at least one left-heart and/or right-heart echocardiographic abnormality. The overall median left ventricular ejection fraction (LVEF) was 65.0% (IQR 58.0-69.0%), with most (44,86.3%) having preserved LVEF. Sixteen patients (31.4%) had increased pulmonary artery systolic pressure, and 14 (27.5%) had right-ventricle (RV) enlargement. During the study period, 12 (23.5%) patients died. LVEF was comparable between survivors and non-survivors, while non-survivors had more often pulmonary hypertension (58.3% vs. 23.1%; P=0.028) and RV enlargement (58.3% vs. 17.9%, P=0.011). Kaplan-Meier analysis demonstrated similar survival curves between patients with vs. without echocardiographic left-heart abnormalities (P=0.450 by log-rank test), while right-heart abnormalities had adverse impact on mortality (P=0.012 by log-rank test). CONCLUSIONS: Typical cardiac abnormality in ICU patients with COVID-19 was right-heart dysfunction with preserved LVEF. Echocardiographic right-heart dysfunction was associated with disease severity and increased mortality in patients affected by COVID-19.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.1101/2020.05.12.20095885
has license	medrxiv
sha1sum (hex)	d7f6fa007b32ff0e6fc2d40f36ad7de1f33cf82c
schema:url	https://doi.org/10.1101/2020.05.12.20095885
resource representing a document's title	Cardiac Structural and Functional Characteristics in Patients with Coronavirus Disease 2019: A Serial Echocardiographic Study
resource representing a document's body	covid:d7f6fa007b32ff0e6fc2d40f36ad7de1f33cf82c#body_text
is schema:about of	named entity 'Study' named entity 'CARDIAC' named entity 'CARDIAC INVOLVEMENT' named entity 'IMPAIRMENTS' named entity 'Running' named entity 'COVID-19' named entity 'COVID-19' named entity 'Echocardiographic' named entity 'medRxiv' named entity 'influenza' named entity 'study protocol' named entity 'vasoconstriction' named entity 'Fibrin degradation product' named entity 'echocardiographic' named entity 'peer review' named entity 'medRxiv' named entity 'emerging infectious diseases' named entity 'diastolic dysfunction' named entity 'necrosis' named entity 'Kaplan-Meier curves' named entity 'left heart' named entity 'cardiovascular diseases' named entity 'LVEF' named entity 'cTnI' named entity 'cytokine storm' named entity 'systolic' named entity 'E/A ratio' named entity 'TAPSE' named entity 'prognosis' named entity 'cardiovascular' named entity 'diastolic function' named entity 'IVS' named entity 'peer review' named entity 'vena contracta' named entity 'medRxiv' named entity 'Clinical outcomes' named entity 'sepsis' named entity 'ECMO' named entity 'interquartile range' named entity 'hypertension' named entity 'high-sensitivity C-reactive protein' named entity 'mitral regurgitation' named entity 'Brain natriuretic peptide' named entity 'C-reactive protein' named entity 'tricuspid regurgitation' named entity 'pulmonary artery pressure' named entity 'intensive care unit' named entity 'subclinical' named entity 'diastolic' named entity 'medRxiv' named entity 'cardiovascular' named entity 'May 18' named entity 'LVEF' named entity 'proportional hazards regression' named entity 'Tricuspid regurgitation' named entity 'postmortem' named entity 'medRxiv' named entity 'COVID' named entity 'risk factors' named entity 'COVID-19' named entity 'echocardiographic' named entity 'coronavirus disease 2019' named entity 'COVID-19' named entity 'Interleukin-6' named entity 'COVID-19' named entity 'peer review' named entity 'COVID' named entity '5.0' named entity 'acute coronary syndromes' named entity 'multiple organ dysfunction' named entity 'confidence intervals'

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