About: Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages

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About: Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
Creator	Wang, Lin-Fa Zhou, Peng Dutertre, Charles-Antoine Ginhoux, Florent Ahn, Matae Bogen, Bjarne Irving, Aaron Chionh, Yok Han, Justin Irac, Sergio Ng, Jia
source	Medline; PMC
abstract	Bats carry and shed many emerging infectious disease agents including Ebola virus and SARS-like Coronaviruses, yet they rarely display clinical symptoms of infection. Bat epithelial or fibroblast cell lines were previously established to study the bat immune response against viral infection. However, the lack of professional immune cells such as dendritic cells (DC) and macrophages has greatly limited the significance of current investigations. Using Pteropus alecto (P. alecto) GM-CSF plus IL4, FLT3L and CSF-1, we successfully generated bat bone marrow-derived DC and macrophages. Cells with the phenotype, morphology and functional features of monocyte-derived DC, bona fide DC or macrophages were obtained in GM-CSF/IL4, FLT3L or CSF-1 cultures, respectively. The successful generation of the first bat bone marrow-derived immune cells paves the way to unlocking the immune mechanisms that confer host resilience to pathogens in bats.
has issue date	2016-12-09(xsd:dateTime)
bibo:doi	10.1038/srep38597
bibo:pmid	27934903
has license	cc-by
sha1sum (hex)	d7a83aa4ab9b3fb17d6fbb6d7fb5e71f3939135f
schema:url	https://doi.org/10.1038/srep38597
resource representing a document's title	Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
has PubMed Central identifier	PMC5146944
has PubMed identifier	27934903
schema:publication	Sci Rep
resource representing a document's body	covid:d7a83aa4ab9b3fb17d6fbb6d7fb5e71f3939135f#body_text
is schema:about of	named entity 'BONE MARROW' named entity 'OPEN' named entity 'CSF' named entity 'immune cells' named entity 'alecto' named entity 'OPEN' named entity 'Pteropus' named entity 'INVESTIGATIONS' named entity 'SIGNIFICANCE' named entity 'CLINICAL SYMPTOMS' named entity 'FLT3L' named entity 'BAT' named entity 'FEATURES' named entity 'RARELY' named entity 'IL4' named entity 'CULTURES' named entity 'DERIVED' named entity 'EPITHELIAL' named entity 'PREVIOUSLY' named entity 'CSF-1' named entity 'PROFESSIONAL' named entity 'RESILIENCE' named entity 'LACK' named entity '28P' named entity 'MORPHOLOGY' named entity 'BONE MARROW' named entity 'CURRENT' named entity 'PTEROPUS ALECTO' named entity 'MACROPHAGES' named entity 'IMMUNE CELLS' named entity 'LIMITED' named entity 'ESTABLISHMENT' named entity 'VIRAL INFECTION' named entity 'DENDRITIC CELLS' named entity 'CORONAVIRUSES' named entity 'MONOCYTE' named entity 'INFECTION' named entity 'BAT' named entity 'MACROPHAGES' named entity 'IMMUNOLOGY' named entity 'FIBROBLAST CELL' named entity 'GENERATION' named entity 'GM-CSF' named entity 'STUDY' named entity 'CELLS' named entity 'WAY' named entity 'DISPLAY' named entity 'IMMUNE' named entity 'PHENOTYPE' named entity 'HOST' named entity 'MECHANISMS' named entity 'GENERATED' named entity 'USING' named entity 'FUNCTIONAL' named entity 'BATS' named entity 'DENDRITIC CELLS' named entity 'SUCCESSFUL' named entity 'CELL LINES' named entity 'IMMUNE RESPONSE' named entity 'OBTAINED' named entity 'PTEROPUS ALECTO' named entity 'DERIVED' named entity 'GREATLY' named entity 'ESTABLISHED' named entity 'PATHOGENS' covid:arg/d7a83aa4ab9b3fb17d6fbb6d7fb5e71f3939135f named entity 'alecto' named entity 'generation' named entity 'infection' named entity 'Paired t-test' named entity 'poly I:C'

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