About: CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent Infection

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About: CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent Infection
Creator	Bernbaum, J Caì, Y Mazur, S Postnikova, E Yú, S
topic	covid:d7a80f6f56131be32a661d7604b38c6a893ded50#this
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently isolated betacoronavirus identified as the etiologic agent of a frequently fatal disease in Western Asia, Middle East respiratory syndrome. Attempts to identify the natural reservoirs of MERS-CoV have focused in part on dromedaries. Bats are also suspected to be reservoirs based on frequent detection of other betacoronaviruses in these mammals. For this study, ten distinct cell lines derived from bats of divergent species were exposed to MERS-CoV. Plaque assays, immunofluorescence assays, and transmission electron microscopy confirmed that six bat cell lines can be productively infected. We found that the susceptibility or resistance of these bat cell lines directly correlates with the presence or absence of cell surface-expressed CD26/DPP4, the functional human receptor for MERS-CoV. Human anti-CD26/DPP4 antibodies inhibited infection of susceptible bat cells in a dose-dependent manner. Overexpression of human CD26/DPP4 receptor conferred MERS-CoV susceptibility to resistant bat cell lines. Finally, sequential passage of MERS-CoV in permissive bat cells established persistent infection with concomitant downregulation of CD26/DPP4 surface expression. Together, these results imply that bats indeed could be among the MERS-CoV host spectrum, and that cellular restriction of MERS-CoV is determined by CD26/DPP4 expression rather than by downstream restriction factors.
has issue date	2014-11-19(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0112060
bibo:pmid	25409519
has license	cc0
sha1sum (hex)	d7a80f6f56131be32a661d7604b38c6a893ded50
schema:url	https://doi.org/10.1371/journal.pone.0112060
resource representing a document's title	CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent Infection
has PubMed Central identifier	PMC4237331
has PubMed identifier	25409519
schema:publication	PLoS One
resource representing a document's body	covid:d7a80f6f56131be32a661d7604b38c6a893ded50#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/d7a80f6f56131be32a661d7604b38c6a893ded50
is schema:about of	named entity 'EVOLUTION' named entity 'INFECTION' named entity 'susceptibility' named entity 'focused' named entity 'reservoirs' named entity 'cell' named entity 'determined' named entity 'Infection' named entity 'Infection' named entity 'Cell' named entity 'BATS' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'RECEPTOR' named entity 'DROMEDARIES' named entity 'OVEREXPRESSION' named entity 'RESISTANCE' named entity 'EXPOSED TO' named entity 'CELLULAR' named entity 'SUSCEPTIBLE' named entity 'PASSAGE' named entity 'ABSENCE OF' named entity 'THESE' named entity 'ISOLATED' named entity 'FUNCTIONAL' named entity 'RESISTANT' named entity 'RATHER' named entity 'STUDY' named entity 'RECENTLY' named entity 'RESERVOIRS' named entity 'SURFACE' named entity 'DETECTION' named entity 'INFECTED' named entity 'HAVE' named entity 'SEQUENTIAL' named entity 'DOWNREGULATION' named entity 'DISTINCT' named entity 'TRANSMISSION ELECTRON MICROSCOPY' named entity 'FOUND' named entity 'SUSCEPTIBILITY' named entity 'CELL' named entity 'EXPRESSION' named entity 'PLAQUE' named entity 'ETIOLOGIC AGENT' named entity 'FREQUENT' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'RESULTS' named entity 'HOST' named entity 'BAT' named entity 'ESTABLISHED' named entity 'CELLS' named entity 'SUSCEPTIBILITY' named entity 'PERSISTENT INFECTION' named entity 'PERSISTENT INFECTION' named entity 'CD26' named entity 'SUSPECTED' named entity 'MIDDLE EAST RESPIRATORY SYNDROME' named entity 'BASED' named entity 'CELLS' named entity 'INFECTION' named entity 'TO IDENTIFY' named entity 'DOWNSTREAM' named entity 'RESTRICTION' named entity 'DOSE-DEPENDENT' named entity 'DERIVED' named entity 'CELL SURFACE' named entity 'IS A' named entity 'SPECTRUM' named entity 'CONCOMITANT' named entity 'DIRECTLY' named entity 'WESTERN ASIA' named entity 'CELL LINES' named entity 'HUMAN' named entity 'ANTIBODIES' named entity 'FATAL DISEASE' named entity 'IDENTIFIED'

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