About: Genus Avipoxvirus

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Genus Avipoxvirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genus Avipoxvirus
Creator	Boyle, David Weber, Olaf Mercer, Andrew Schmidt, Axel
topic	covid:d78b87cc664a3641715e637834f2242370a69f58#this
Source	PMC
abstract	Poxviruses identified in skin lesions of domestic, pet or wild birds are assigned largely by default to the Avipoxvirus genus within the subfamily Chordopoxvirinae of the family Poxviridae. Avipoxviruses have been identified as the causative agent of disease in at least 232 species in 23 orders of birds. Vaccines based upon attenuated avipoxvirus strains provide good disease control in production poultry, although with the large and intensive production systems there are suggestions and real risks of emergence of strains against which current vaccines might be ineffective. Sequence analysis of the whole genome has revealed overall genome structure and function resemblance to the Chordopoxvirinae; however, avipoxvirus genomes exhibit large-scale genomic rearrangements with more extensive gene families and novel host range gene in comparison with the other Chordopoxvirinae. Phylogenetic analysis places the avipoxviruses externally to the Chorodopoxvirinae to such an extent that in the future it might be appropriate to consider the Avipoxviruses as a separate subfamily within the Poxviridae. A unique relationship exists between Fowlpox virus (FWPV) and reticuloendothelosis viruses. All FWPV strains carry a remnant long terminal repeat, while field strains carry a near full-length provirus integrated at the same location in the FWPV genome. With the development of techniques to construct poxviruses expressing foreign vaccine antigens, the avipoxviruses have gone from neglected obscurity to important vaccine vectors in the past 20 years. The seminal observation of their utility for delivery of vaccine antigens to non-avian species has driven much of the interest in this group of viruses. In the veterinary area, several recombinant avipoxviruses are commercially licensed vaccines. The most successful have been those expressing glycoprotein antigens of enveloped viruses, e.g. avian influenza, Newcastle diseases and West Nile viruses. Several recombinants have undergone extensive human clinical trials as experimental vaccines against HIV/AIDS and malaria or as treatment regimens in cancer patients. The safety profile of avipoxvirus recombinants for use as veterinary and human vaccines or therapeutics is now well established.
has issue date	2007-01-01(xsd:dateTime)
bibo:doi	10.1007/978-3-7643-7557-7_11
has license	no-cc
sha1sum (hex)	d78b87cc664a3641715e637834f2242370a69f58
schema:url	https://doi.org/10.1007/978-3-7643-7557-7_11
resource representing a document's title	Genus Avipoxvirus
has PubMed Central identifier	PMC7123973
schema:publication	Poxviruses
resource representing a document's body	covid:d78b87cc664a3641715e637834f2242370a69f58#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/d78b87cc664a3641715e637834f2242370a69f58
is schema:about of	named entity 'wild birds' named entity 'antigens' named entity 'genome' named entity 'provirus' named entity 'development' named entity 'With' named entity 'vaccine' named entity 'vaccines' named entity 'based' named entity 'real' named entity 'AVIPOXVIRUS' named entity 'IDENTIFIED' named entity 'VECTORS' named entity 'COMPARISON' named entity 'OVERALL' named entity '232' named entity 'ORDERS' named entity 'FUNCTION' named entity 'CARRY' named entity 'IN THE PAST' named entity 'DEFAULT' named entity 'RESEMBLANCE' named entity 'SKIN LESIONS' named entity 'OBSERVATION' named entity 'AVIAN INFLUENZA' named entity 'CLINICAL TRIALS' named entity 'EXTENSIVE' named entity 'POULTRY' named entity 'VIRUSES' named entity 'CHORDOPOXVIRINAE' named entity 'DEVELOPMENT' named entity 'DELIVERY' named entity 'CONSIDER' named entity 'DRIVEN' named entity 'APPROPRIATE' named entity 'PATIENTS' named entity 'MIGHT BE' named entity 'YEARS' named entity 'FOWLPOX VIRUS' named entity 'VACCINE' named entity 'NOVEL' named entity 'BASED' named entity 'RISKS' named entity 'RECOMBINANTS' named entity 'USE' named entity 'ASSIGNED' named entity 'SEMINAL' named entity 'DISEASES' named entity 'GOOD' named entity 'ATTENUATED' named entity 'GENUS' named entity 'SCALE' named entity 'ESTABLISHED' covid:arg/d78b87cc664a3641715e637834f2242370a69f58 named entity 'MUCH' named entity 'SUBFAMILY CHORDOPOXVIRINAE' named entity 'POXVIRUSES' named entity 'GENE FAMILIES' named entity 'BIRDS' named entity 'THERAPEUTICS' named entity 'SUBFAMILY' named entity 'EMERGENCE' named entity 'UNIQUE' named entity 'AVIAN' named entity 'UTILITY' named entity 'PET' named entity 'CONSTRUCT' named entity 'HOST RANGE' named entity 'REVEALED' named entity 'CURRENT' named entity 'PLACES' named entity 'LONG TERMINAL REPEAT' named entity 'NEGLECTED' named entity 'FOREIGN' named entity 'POXVIRIDAE' named entity 'VETERINARY' named entity 'CAUSATIVE AGENT' named entity 'REAL'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software