About: Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile

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About: Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile
Creator	Chen, Hui-Wen Chen, You-Ting Chen, Ting-Chih Li, Yao-Tsun Lin, Shu-Yi Hu, Che-Ming
Source	Medline; PMC
abstract	Avian coronavirus infectious bronchitis virus (IBV) poses economic threat to the poultry industry worldwide. Pathogenic IBV 3575/08 was isolated from broilers vaccinated with the attenuated viral vaccine derived from a Taiwan strain 2575/98. In this study, extensive investigations were conducted on the genome sequences, antigenicity, pathogenicity, and host immune responses of several IBV strains in specific-pathogen-free chickens. Sequence analyses revealed that 3575/08 and 2575/98 shared high homology in their structural genes, but not in non-structural accessory proteins such as 3a, 3b and 5b. Despite a high degree of homology in their spike protein genes, cross neutralization test showed low cross protection between 3575/08 and 2575/98, suggesting distinct antigenicity for the two strains. Animal challenge experiments exhibited strong respiratory and renal pathogenicity for 3575/08. In addition, early and prolonged viral shedding and rapid viral dissemination were observed. Immune gene expression profiling by PCR array showed chickens infected with 3575/08 had delayed expression of a subset of early innate immune genes, whereas chickens infected with the wild-type or attenuated-type 2575/08 revealed quick gene induction and efficient virus control. In summary, this study reveals a new IBV strain, which harbors a known local genotype but displays remarkably altered antigenicity, pathogenicity and host defenses.
has issue date	2016-11-23(xsd:dateTime)
bibo:doi	10.1038/srep37725
bibo:pmid	27876864
has license	cc-by
sha1sum (hex)	d7803599fa57f39b06d7fd5bc8986420ae13fc2c
schema:url	https://doi.org/10.1038/srep37725
resource representing a document's title	Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile
has PubMed Central identifier	PMC5120290
has PubMed identifier	27876864
schema:publication	Sci Rep
resource representing a document's body	covid:d7803599fa57f39b06d7fd5bc8986420ae13fc2c#body_text
is schema:about of	named entity 'OPEN' named entity 'INFECTIOUS BRONCHITIS' named entity 'IDENTIFICATION' named entity 'quick' named entity 'rapid' named entity 'altered' named entity 'attenuated' named entity 'conducted' named entity 'early' named entity 'Taiwan' named entity 'antigenicity' named entity 'ALTERED' named entity 'ANTIGENICITY' named entity 'PROFILE' named entity 'ACCESSORY' named entity 'INVESTIGATIONS' named entity 'PROTEIN ' named entity 'HOMOLOGY' named entity 'HIGH' named entity 'VIRAL SHEDDING' named entity 'ALTERED' named entity 'INFECTED' named entity 'ADDITION' named entity 'KNOWN' named entity 'PROTEINS' named entity 'LOCAL' named entity 'RAPID' named entity 'IMMUNE' named entity 'LOW' named entity 'STRAIN' named entity 'PROLONGED' named entity 'EXTENSIVE' named entity 'CROSS PROTECTION' named entity 'IMMUNE RESPONSES' named entity 'VIRUS' named entity 'STRUCTURAL GENES' named entity 'RENAL' named entity 'REVEALED' named entity 'NEUTRALIZATION TEST' named entity 'EXPERIMENTS' named entity 'WILD-TYPE' named entity 'ATTENUATED' named entity 'STRUCTURAL' named entity 'RESPIRATORY' named entity 'DERIVED' named entity 'EFFICIENT' named entity 'THEIR' named entity 'ANTIGENICITY' named entity 'NEW' named entity 'CROSS' named entity 'SEQUENCE' named entity 'ANIMAL' named entity 'SEQUENCES' named entity 'STRONG' named entity 'IBV' named entity 'CHICKENS' named entity 'QUICK' named entity 'VACCINATED' named entity 'BUT' named entity 'CLASSICAL' named entity 'EXHIBITING' named entity 'CORONAVIRUS' named entity 'VIRAL' named entity 'GENE' named entity 'EARLY' covid:arg/d7803599fa57f39b06d7fd5bc8986420ae13fc2c named entity 'GENE EXPRESSION PROFILING' named entity 'PCR ARRAY' named entity 'GENOTYPE' named entity 'SPIKE PROTEIN' named entity 'GENOTYPE' named entity 'INNATE IMMUNITY' named entity 'PATHOGENIC' named entity 'STRAINS' named entity 'VIRAL VACCINE' named entity 'CHALLENGE'

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