About: The effect of respiratory viral assay panel on antibiotic prescription patterns at discharge in adults admitted with mild to moderate acute exacerbation of COPD: a retrospective before- after study

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About: The effect of respiratory viral assay panel on antibiotic prescription patterns at discharge in adults admitted with mild to moderate acute exacerbation of COPD: a retrospective before- after study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The effect of respiratory viral assay panel on antibiotic prescription patterns at discharge in adults admitted with mild to moderate acute exacerbation of COPD: a retrospective before- after study
Creator	Snydman, David Andujar-Vazquez, Gabriela Bardia, Amit Doron, Shira Gardiner, Bradley Kurz, Sebastian Ruthazer, Robin Tickoo, Mayanka
source	Medline; PMC
abstract	BACKGROUND: Despite well-defined criteria for use of antibiotics in patients presenting with mild to moderate Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD), their overuse is widespread. We hypothesized that following implementation of a molecular multiplex respiratory viral panel (RVP), AECOPD patients with viral infections would be more easily identified, limiting antibiotic use in this population. The primary objective of our study was to investigate if availability of the RVP decreased antibiotic prescription at discharge among patients with AECOPD. METHODS: This is a single center, retrospective, before (pre-RVP) - after (post-RVP) study of patients admitted to a tertiary medical center from January 2013 to March 2016. The primary outcome was antibiotic prescription at discharge. Groups were compared using univariable and multivariable logistic-regression. RESULTS: A total of 232 patient-episodes were identified, 133 following RVP introduction. Mean age was 68.1 (pre-RVP) and 68.3 (post-RVP) years respectively (p = 0.88). Patients in pre-RVP group were similar to the post-RVP group with respect to gender (p = 0.54), proportion of patients with BMI < 21(p = 0.23), positive smoking status (p = 0.19) and diagnoses of obstructive sleep apnea (OSA, p = 0.16). We found a significant reduction in antibiotic prescription rate at discharge in patients admitted with AECOPD after introduction of the respiratory viral assay (pre-RVP 77.8% vs. post-RVP 63.2%, p = 0.01). In adjusted analyses, patients in the pre-RVP group [OR 2.11 (CI: 1.13–3.96), p = 0.019] with positive gram stain in sputum [OR 4.02 (CI: 1.61–10.06), p = 0.003] had the highest odds of antibiotic prescription at discharge. CONCLUSIONS: In patients presenting with mild to moderate Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD), utilization of a comprehensive respiratory viral panel can significantly decrease the rate of antibiotic prescription at discharge.
has issue date	2019-07-01(xsd:dateTime)
bibo:doi	10.1186/s12890-019-0872-0
bibo:pmid	31262278
has license	cc-by
sha1sum (hex)	d72501b217d2f47435246abaa30b22aa1f504dc0
schema:url	https://doi.org/10.1186/s12890-019-0872-0
resource representing a document's title	The effect of respiratory viral assay panel on antibiotic prescription patterns at discharge in adults admitted with mild to moderate acute exacerbation of COPD: a retrospective before- after study
has PubMed Central identifier	PMC6604457
has PubMed identifier	31262278
schema:publication	BMC Pulm Med
resource representing a document's body	covid:d72501b217d2f47435246abaa30b22aa1f504dc0#body_text
is schema:about of	named entity 'molecular' named entity 'viral' named entity 'antibiotic' named entity 'PATIENTS' named entity 'well-defined' named entity 'discharge' named entity 'antibiotic' named entity 'overuse' named entity 'viral infections' named entity 'Acute Exacerbation of Chronic Obstructive Pulmonary Disease' named entity 'acute exacerbation of COPD' named entity 'antibiotic' named entity 'antimicrobial resistance' named entity 'ICD 10' named entity 'cough' named entity 'antibiotic' named entity 'dyspnea' named entity 'hospital care' named entity 'diabetes' named entity 'antibiotics' named entity 'single center' named entity 'hypertension' named entity 'health care cost' named entity 'bronchodilators' named entity 'purulent' named entity 'shortness of breath' named entity 'clinical diagnostics' named entity 'real-time PCR' named entity 'ICU' named entity 'Kruskal-Wallis test' named entity 'antibiotic' named entity 'distilling' named entity 'antibiotic' named entity 'etiologies' named entity 'COPD' named entity 'antibiotics' named entity 'logistic regression' named entity 'antibiotics' named entity 'BMI' named entity 'serology' named entity 'etiology' named entity 'coronary artery disease' named entity 'COPD exacerbation' named entity 'purulence' named entity 'ICU' named entity 'antibiotic' named entity 'COPD' named entity 'clinical care' named entity 'viral illnesses' named entity 'gram stain' named entity 'antibiotics' named entity 'pathogens' named entity 'congestive heart failure' named entity 'decision-making' named entity 'obstructive sleep apnea' named entity 'COPD' named entity 'gram stain' named entity 'p-values' named entity 'PCR based' named entity 'influenza like illnesses' named entity 'antibiotics' named entity 'overuse of antibiotics' named entity 'COPD' named entity 'antibiotic resistance' named entity 'antibiotic' named entity 'antibiotic' named entity 'COPD' named entity 'outpatient setting' named entity 'purulent' named entity 'sputum' named entity 'acute exacerbation of COPD' named entity 'bacteremia' named entity 'Salt Lake City' named entity 'antibiotic'

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