About: Palmitoylation of the feline immunodeficiency virus envelope glycoprotein and its effect on fusion activity and envelope incorporation into virions

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About: Palmitoylation of the feline immunodeficiency virus envelope glycoprotein and its effect on fusion activity and envelope incorporation into virions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Palmitoylation of the feline immunodeficiency virus envelope glycoprotein and its effect on fusion activity and envelope incorporation into virions
Creator	Affranchino, José Gonzá Lez, Silvia Paladino, G
Source	Elsevier; Medline; PMC
abstract	The feline immunodeficiency virus (FIV) envelope glycoprotein (Env) possesses a short cytoplasmic domain of 53 amino acids containing four highly conserved cysteines at Env positions 804, 811, 815 and 848. Since palmitoylation of transmembrane proteins occurs at or near the membrane anchor, we investigated whether cysteines 804, 811 and 815 are acylated and analyzed the relevance of these residues for Env functions. Replacement of cysteines 804, 811 and 815 individually or in combination by serine residues resulted in Env glycoproteins that were efficiently expressed and processed. However, mutations C804S and C811S reduced Env fusogenicity by 93% and 84%, respectively, compared with wild-type Env. By contrast, mutant C815S exhibited a fusogenic capacity representing 50% of the wild-type value. Remarkably, the double mutation C804S/C811S abrogated both Env fusion activity and Env incorporation into virions. Finally, by means of Click chemistry assays we demonstrated that the four FIV Env cytoplasmic cysteines are palmitoylated.
has issue date	2012-06-20(xsd:dateTime)
bibo:doi	10.1016/j.virol.2012.03.005
bibo:pmid	22503389
has license	no-cc
sha1sum (hex)	d722ca67e2988e249b4bd69026267a5534e3c7cb
schema:url	https://doi.org/10.1016/j.virol.2012.03.005
resource representing a document's title	Palmitoylation of the feline immunodeficiency virus envelope glycoprotein and its effect on fusion activity and envelope incorporation into virions
has PubMed Central identifier	PMC7111954
has PubMed identifier	22503389
schema:publication	Virology
resource representing a document's body	covid:d722ca67e2988e249b4bd69026267a5534e3c7cb#body_text
is schema:about of	named entity 'envelope' named entity 'Click chemistry' named entity 'domain' named entity 'However' named entity 'anchor' named entity 'fusion' named entity 'VIRIONS' covid:arg/d722ca67e2988e249b4bd69026267a5534e3c7cb named entity 'TRANSMEMBRANE PROTEINS' named entity 'DEMONSTRATED' named entity 'PALMITOYLATION' named entity 'CAPACITY' named entity 'FIV' named entity 'CYSTEINES' named entity 'GLYCOPROTEINS' named entity 'REDUCED' named entity 'POSSESSES' named entity 'MEMBRANE' named entity 'COMPARED' named entity 'CLICK CHEMISTRY' named entity 'VALUE' named entity 'MUTATIONS' named entity 'WILD-TYPE' named entity 'COMBINATION' named entity 'SHORT' named entity 'INVESTIGATED' named entity 'EFFECT' named entity 'FELINE IMMUNODEFICIENCY VIRUS' named entity 'SERINE' named entity 'VIRIONS' named entity 'ACTIVITY' named entity 'ENVELOPE' named entity 'VIRUS ENVELOPE' named entity 'FUSION' named entity 'ITS' named entity 'ANCHOR' named entity 'CYTOPLASMIC' named entity '50%' named entity 'PALMITOYLATED' named entity 'ENVELOPE GLYCOPROTEIN' named entity 'NEAR' named entity 'ENV' named entity 'CYTOPLASMIC DOMAIN' named entity 'MUTATION' named entity 'MEANS' named entity 'DOUBLE' named entity 'FUSION' named entity 'EXPRESSED' named entity 'PALMITOYLATION' named entity 'ACTIVITY' named entity 'ANALYZED' named entity 'RELEVANCE' named entity '804' named entity 'HIGHLY' named entity 'THESE' named entity 'AMINO ACIDS' named entity 'PROCESSED' named entity 'CONTRAST' named entity 'FUNCTIONS' named entity 'REPLACEMENT' named entity 'CONTAINING' named entity 'POSITIONS' named entity 'CONSERVED' named entity 'MUTANT' named entity 'ENVELOPE GLYCOPROTEIN' named entity 'FELINE IMMUNODEFICIENCY VIRUS' named entity 'investigated' named entity 'glycoproteins' named entity 'combination' named entity 'virions' named entity 'incorporation' named entity 'Click chemistry' named entity 'Env' named entity 'palmitoylation' named entity 'Env' named entity 'FIV' named entity 'Env' named entity 'cytoplasmic domain' named entity 'amino acids'

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