About: A Functionally Different Immune Phenotype in Cattle Is Associated With Higher Mastitis Incidence

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About: A Functionally Different Immune Phenotype in Cattle Is Associated With Higher Mastitis Incidence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Functionally Different Immune Phenotype in Cattle Is Associated With Higher Mastitis Incidence
Creator	Lutterberg, Karina Nüske, Stefan Brugman, Sylvia Deeg, Cornelia Hauck, Stefanie Hobmaier, Bernhard Kleinwort, Kristina Scholz, Armin Van, Willem
Source	PMC
abstract	A novel vaccine against bovine viral diarrhea (BVD) induced pathogenic antibody production in 5–10% of BVD-vaccinated cows. Transfer of these antibodies via colostrum caused Bovine neonatal pancytopenia (BNP) in calves, with a lethality rate of 90%. The exact immunological mechanisms behind the onset of BNP are not fully understood to date. To gain further insight into these mechanisms, we analyzed the immune proteome from alloreactive antibody producers (BNP cows) and non-responders. After in vitro stimulation of peripheral blood derived lymphocytes (PBL), we detected distinctly deviant expression levels of several master regulators of immune responses in BNP cells, pointing to a changed immune phenotype with severe dysregulation of immune response in BNP cows. Interestingly, we also found this response pattern in 22% of non-BVD-vaccinated cows, indicating a genetic predisposition of this immune deviant (ID) phenotype in cattle. We additionally analyzed the functional correlation of the ID phenotype with 10 health parameters and 6 diseases in a retrospective study over 38 months. The significantly increased prevalence of mastitis among ID cows emphasizes the clinical relevance of this deviant immune response and its potential impact on the ability to fight infections.
has issue date	2018-12-06(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.02884
bibo:pmid	30574152
has license	cc-by
sha1sum (hex)	d7101f63979fbbfbce1f7b9b1e6bd51f50adfd02
schema:url	https://doi.org/10.3389/fimmu.2018.02884
resource representing a document's title	A Functionally Different Immune Phenotype in Cattle Is Associated With Higher Mastitis Incidence
has PubMed Central identifier	PMC6291514
has PubMed identifier	30574152
schema:publication	Front Immunol
resource representing a document's body	covid:d7101f63979fbbfbce1f7b9b1e6bd51f50adfd02#body_text
is schema:about of	named entity 'PHENOTYPE' named entity 'POTENTIAL' named entity 'STIMULATION' named entity 'CATTLE' named entity 'ONSET OF' named entity 'CORRELATION' named entity 'CELLS' named entity 'NEONATAL' named entity 'INDUCED' named entity 'IMMUNE RESPONSES' named entity 'MONTHS' named entity 'TRANSFER' named entity 'BOVINE VIRAL DIARRHEA' named entity 'ITS' named entity 'RESPONSE' named entity 'FULLY' named entity 'CHANGED' named entity 'LEVELS' named entity 'CALVES' named entity 'THESE' named entity 'DEVIANT' named entity 'PRODUCERS' named entity 'PATTERN' named entity 'PHENOTYPE' named entity 'IMMUNE RESPONSE' named entity 'LETHALITY' named entity 'IMMUNE' named entity 'INSIGHT' named entity 'MECHANISMS' named entity 'MASTITIS' named entity 'FOUND' named entity 'INFECTIONS' named entity 'ASSOCIATED WITH' named entity 'DIFFERENT' named entity 'HIGHER' named entity 'VACCINATED' named entity 'IN VITRO' named entity 'COLOSTRUM' named entity 'PREVALENCE' named entity 'DETECTED' named entity 'SEVERE' named entity 'INDICATING' named entity 'VACCINE' named entity 'COWS' named entity 'CAUSED' named entity 'GENETIC PREDISPOSITION' named entity 'UNDERSTOOD' named entity 'INCREASED' named entity 'PARAMETERS' named entity 'LYMPHOCYTES' named entity 'ANTIBODIES' named entity 'CLINICAL RELEVANCE' named entity 'ANALYZED' named entity 'PANCYTOPENIA' named entity 'REGULATORS' named entity 'DISEASES' named entity 'FUNCTIONAL' named entity 'NON-' named entity 'DATE' named entity '90%' named entity 'BNP' named entity 'MASTER' named entity 'PERIPHERAL BLOOD' named entity 'CATTLE' named entity 'NOVEL' named entity 'GAIN' named entity 'PATHOGENIC' named entity '5-10' named entity 'FIGHT' named entity 'BOVINE' named entity 'ANTIBODY' named entity 'ANTIBODY PRODUCTION' named entity 'EXACT'

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