About: Anti-viral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus

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About: Anti-viral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Anti-viral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus
Creator	Kaushik, Sulochana Yadav, Parkash Jangra, Ginni Jaya, · Kaushik, · Kundu, ·
Source	PMC
abstract	Chikungunya is one of the highly infectious viral disease without vaccine and anti-viral. Aim of present study is to check the anti-chikungunya activities of Zingiber officinale (Ginger) in the animal cell culture model. The medicinal plant extract was prepared from Z. officinale rhizome. Median tissue culture infective dose (TCID(50)) of Chikungunya virus (CHIKV) and Maximum non-toxic dose (MNTD) of Z. officinale extract was determined in Vero cell-line on the basis of cell viability followed by MTT assay. In vitro anti-chikungunya activity was performed in Vero cell-line with MNTD and half of MNTD of Z. officinale medicinal plant extract. The anti-viral effect of Z. officinale was studied by observing the cytopathic effects and cell viability measured by MTT assay. Maximum non-toxic dose of Z. officinale plant extract was found 62.5 μg/ml. During anti-chikungunya experimentation, cell viability increased to 51.05% and 35.10%, when Vero cells were pre-treated with MNTD and half of MNTD of Z. officinale extract respectively. Similarly, in co-treatment, when MNTD, half of MNTD of Z. officinale and Median tissue culture infective dose CHIKV were inoculated simultaneously, then the viability of Vero cell-line was increases by 52.90% and 49.02% respectively. The rhizome extracts of Z. officinale have high potential to treat CHIKV. Medicinal plants and their metabolites are most important sources of antimicrobial and can be utilized for the development of new drugs. In view of the rapid expansion of CHIKV at the global level, there is an urgent need to develop newer anti-chikungunya drugs.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1007/s13337-020-00584-0
bibo:pmid	32420412
has license	no-cc
sha1sum (hex)	d65df122d3a7d1204c2ce5256ee249f5955ff4e4
schema:url	https://doi.org/10.1007/s13337-020-00584-0
resource representing a document's title	Anti-viral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus
has PubMed Central identifier	PMC7223110
has PubMed identifier	32420412
schema:publication	Virusdisease
resource representing a document's body	covid:d65df122d3a7d1204c2ce5256ee249f5955ff4e4#body_text
is schema:about of	named entity 'infective' named entity 'cell' named entity 'activities' named entity 'Ginger' named entity 'dose' named entity 'MTT assay' named entity 'extract' named entity 'rhizome' named entity 'viability' named entity 'basis' named entity 'anti-viral' named entity 'activity' named entity 'rhizome' named entity 'viral disease' named entity 'plant extract' named entity 'study' named entity 'studied' named entity 'Z. officinale' named entity 'Z. officinale' named entity 'Z. officinale' named entity 'tissue culture' named entity 'chikungunya' named entity 'Chikungunya' named entity 'Vero cell' named entity 'Zingiber officinale' named entity 'non-toxic' named entity 'CHIKV' named entity 'medicinal plant' named entity 'Vero cell' named entity 'cell viability' named entity 'Vero' named entity 'assay' named entity 'antimicrobial' named entity 'muscle soreness' named entity 'chikungunya' named entity 'Zingiber officinale' named entity 'Togaviridae' named entity 'virus' named entity 'A. aegypti' named entity 'Vero cells' named entity 'cervical cancer' named entity 'chikungunya' named entity 'therapeutic agents' named entity 'anticarcinogenic' named entity 'AIIMS' named entity 'medicinal plant' named entity 'infection' named entity 'Madin-Darby Canine Kidney' named entity 'medicinal plant' named entity 'Z. officinale' named entity 'absorbance' named entity 'Z. officinale' named entity 'Vero cell' named entity 'pathogen' named entity 'drug resistance' named entity 'Guillain-Barré syndrome' named entity 'Nipah virus' named entity 'andrographolide' named entity 'medicinal plant' named entity 'adsorption' named entity 'stomach upset' named entity 'Mayotte' named entity 'laxative' named entity 'inverted microscope' named entity 'CHIKV' named entity 'Chikungunya' named entity 'chikungunya' named entity '37°C' named entity 'virus' named entity 'vaccine' named entity 'anti-inflammatory' named entity 'Optic Neuritis' named entity 'rhizome' named entity 'aqueous solution' named entity 'vector' named entity 'side-effects'

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