About: The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo
Creator	Luo, Jun Hou, Wei Xiao, Hong Xiong, Hai-Rong Yang, Zhan-Qiu
topic	covid:d653d9860ec8395a6d1b7f6369c51b8e63dfe214#this
Source	Elsevier; Medline; PMC
abstract	Abstract Aim of the study Herpes simplex viruses (HSV-1 and -2) are important pathogens for humans and the discovery of novel anti-HSV drugs with low toxicity deserves great efforts. Rhubarb is one of the oldest and best-known traditional Chinese medicines. We initiated this study to test if emodin is the active ingredients from Rheum tanguticum (R. tanguticum, one of the Chinese Rhubarb) against HSV infection and to investigate its antiviral activity on HSV infection in tissue culture cells and in a mouse model. Materials and methods Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) was extracted and purified from R. tanguticum (cultivated at high mountainous area in Qinghai) and the purity was determined by high performance liquid chromatography. The antiviral experiments of emodin against HSV infection were performed in vitro and in vivo. In vivo, the HSV-infected mice were orally administered with emodin beginning at 24h post-HSV exposures with dosages of 3.3g/kg/day, 6.7g/kg/day, and 11.3g/kg/day, respectively, for 7 days. Results Emodin was found to inhibit the replication of HSV-1 and HSV-2 in cell culture at the concentration of 50μg/ml with antiviral index of 2.07 and 3.53, respectively. The emodin treatment increased the survival rate of HSV-infected mice, prolonged survival time and showed higher efficacy of HSV elimination from brain, heart, liver and ganglion, compared to the viral controls. In addition, the antiviral activity of emodin was found to be equivalent to that of acyclovir in vivo. Conclusions Our results indicate that emodin has the anti-HSV activity in vitro and in vivo and is thus a promising agent in the clinical therapy of HSV infection.
has issue date	2011-01-27(xsd:dateTime)
bibo:doi	10.1016/j.jep.2010.10.059
bibo:pmid	21050882
has license	els-covid
sha1sum (hex)	d653d9860ec8395a6d1b7f6369c51b8e63dfe214
schema:url	https://doi.org/10.1016/j.jep.2010.10.059
resource representing a document's title	The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo
has PubMed Central identifier	PMC7126445
has PubMed identifier	21050882
schema:publication	Journal of Ethnopharmacology
resource representing a document's body	covid:d653d9860ec8395a6d1b7f6369c51b8e63dfe214#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/d653d9860ec8395a6d1b7f6369c51b8e63dfe214
is schema:about of	named entity 'IN VITRO' named entity 'EMODIN' named entity 'agent' named entity 'Rhubarb' named entity 'purified' named entity 'day' named entity 'emodin' named entity 'infection' named entity 'study' named entity 'high' named entity 'BEGINNING' named entity 'HSV INFECTION' named entity 'OUR' named entity 'TRIHYDROXYANTHRAQUINONE' named entity 'INFECTED' named entity 'HEART' named entity 'EFFICACY' named entity 'AGENT' named entity 'IMPORTANT' named entity 'ANTIVIRAL' named entity 'PROLONGED' named entity '2C6' named entity 'EXPERIMENTS' named entity 'PURIFIED' named entity 'EXTRACTED' named entity 'INCREASED' named entity 'HIGH PERFORMANCE LIQUID CHROMATOGRAPHY' named entity 'FOUND' named entity 'LIVER' named entity 'ORALLY' named entity 'EMODIN' named entity 'ANTIVIRAL ACTIVITY' named entity 'TREATMENT' named entity 'CONCENTRATION OF' named entity '3.3' named entity 'HSV' named entity 'PATHOGENS' named entity 'CHINESE MEDICINES' named entity 'GANGLION' named entity 'ADMINISTERED' named entity 'TO INHIBIT' named entity 'ELIMINATION' named entity 'HUMANS' named entity 'MOUSE MODEL' named entity 'INDEX' named entity 'METHODS' named entity 'CELLS' named entity 'A MOUSE' named entity 'HERPES SIMPLEX VIRUSES' named entity 'SURVIVAL TIME' named entity 'CLINICAL' named entity 'STUDY' named entity 'HSV-2' named entity '283' named entity 'RHEUM TANGUTICUM' named entity 'EQUIVALENT' named entity 'HERPES SIMPLEX VIRUS' named entity 'AIM' named entity 'BRAIN' named entity 'MICE' named entity 'VIRAL' named entity 'THERAPY' named entity 'AREA' named entity 'ONE OF' named entity 'LOW TOXICITY' named entity 'DOSAGES' named entity 'TO INVESTIGATE' named entity 'ADDITION' named entity 'ACTIVE INGREDIENTS' named entity 'POST' named entity 'IN VIVO' named entity 'ACYCLOVIR' named entity 'MATERIALS' named entity 'REPLICATION' named entity 'BEST'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software