About: Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis

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About: Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis
Creator	Wang, Yu Deng, Yao Tan, Wenjie Wang, Wenling Wang, Yanqun Lu, Roujian Wu, Jun Zhao, Yanjie Zhou, Weimin Liu, Di Ren, Hongguang Shi, Weifeng Wu, Guizhen Gao, George Buchmeier, Michael Wang, Citation Deng, Zhao Gf, Gao Wang, Wu
Source	Medline; PMC
abstract	The Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe acute respiratory tract infection with a high fatality rate in humans. Coronaviruses are capable of infecting multiple species and can evolve rapidly through recombination events. Here, we report the complete genomic sequence analysis of a MERS-CoV strain imported to China from South Korea. The imported virus, provisionally named ChinaGD01, belongs to group 3 in clade B in the whole-genome phylogenetic tree and also has a similar tree topology structure in the open reading frame 1a and -b (ORF1ab) gene segment but clusters with group 5 of clade B in the tree constructed using the S gene. Genetic recombination analysis and lineage-specific single-nucleotide polymorphism (SNP) comparison suggest that the imported virus is a recombinant comprising group 3 and group 5 elements. The time-resolved phylogenetic estimation indicates that the recombination event likely occurred in the second half of 2014. Genetic recombination events between group 3 and group 5 of clade B may have implications for the transmissibility of the virus.
has issue date	2015-09-08(xsd:dateTime)
bibo:doi	10.1128/mbio.01280-15
bibo:pmid	26350969
has license	cc-by-nc-sa
sha1sum (hex)	d5f6841f61ab1b11599f16043c48b9268be6e134
schema:url	https://doi.org/10.1128/mbio.01280-15
resource representing a document's title	Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis
has PubMed Central identifier	PMC4600111
has PubMed identifier	26350969
schema:publication	mBio
resource representing a document's body	covid:d5f6841f61ab1b11599f16043c48b9268be6e134#body_text
is schema:about of	named entity 'CHINA' named entity 'imported' named entity 'Here' named entity 'high' named entity 'severe' named entity 'Origin' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'CASE' named entity 'RAPIDLY' named entity 'SEQUENCE ANALYSIS' named entity '2015' named entity 'CASE' named entity 'ACUTE RESPIRATORY TRACT INFECTION' named entity 'HUMANS' named entity 'PHYLOGENETIC TREE' named entity 'ESTIMATION' named entity 'STRUCTURE' named entity 'MAY HAVE' named entity 'IS A' named entity 'TRANSMISSION' named entity 'INFECTING' named entity 'PHYLOGENETICS' named entity 'GROUP 5 ELEMENTS' named entity 'GENOMIC SEQUENCE' named entity 'CHINA' named entity 'GENETIC RECOMBINATION' named entity 'VIRUS' named entity 'TIME' named entity 'LIKELY' named entity 'POSSIBLE' named entity 'GENE SEGMENT' named entity 'TOPOLOGY' named entity 'PRESENT' named entity 'ANALYSIS' named entity 'DUE TO' named entity 'COALESCENCE' named entity 'SPECIES' named entity 'EVOLVE' named entity 'MEDIA ATTENTION' named entity 'RECENT' named entity 'SPECIFIC' named entity 'HERE' named entity 'GENETIC RECOMBINATION' named entity 'PHYLOGENETICS' named entity 'IMPORTED' named entity 'ANALYSIS' named entity 'COALESCENCE' named entity 'ORIGIN' named entity 'CONSTRUCTED' named entity 'CAPABLE' named entity 'COMPARISON' named entity 'SEVERE' named entity 'USING' named entity 'GROUP 5' named entity 'CLADE' named entity 'SECOND HALF' named entity 'SIMILAR' named entity 'CORONAVIRUSES' named entity 'CAUSES' named entity 'MULTIPLE' named entity 'POLYMORPHISM' named entity 'CLUSTERS' named entity 'RATE'

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