About: Evaluation of an enzyme‐linked immunosorbent assay that measures rhinovirus‐specific antibodies in human sera and nasal secretions

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About: Evaluation of an enzyme‐linked immunosorbent assay that measures rhinovirus‐specific antibodies in human sera and nasal secretions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of an enzyme‐linked immunosorbent assay that measures rhinovirus‐specific antibodies in human sera and nasal secretions
Creator	Barclay, Wendy Ai-Nakib, Widad Callow, Kathleen Sergeant, Marianne
Source	PMC
abstract	Rhinovirus‐specific antibodies have traditionally been detected by their ability to neutralise the homologous rhinovirus serotype in tissue culture. Recently, however, we have described an enzyme‐linked immunosorbent assay that detects rhinovirus‐specific antibodies in sera and nasal secretions [Barclay and Al‐Nakib, 1987]. Here we describe an evaluation of the ELISA in a study involving 71 adult volunteers inoculated intranasally with human rhinovirus type 2 (HRV‐2). Pre‐and post‐inoculation serum samples and pre‐inoculation nasal washings were tested for the presence of HRV‐2‐specific antibodies by ELISA. Such antibodies were associated with protection against infection when present locally in nasal secretions, but when also present in the serum they were associated with protection against both infection and the development of illness. The antibody concentrations showed strong correlation with each other and with that of antibodies detected by the neutralisation test. Following HRV‐2 infection, rises in HRV‐2‐specific IgA in sera detected by ELISA occurred more frequently than rises in neutralizing antibody. These results suggest that the ELISA is a sensitive and reliable indicator of recent infection, as well as a predictor of homologous immune status.
has issue date	2005-12-07(xsd:dateTime)
bibo:doi	10.1002/jmv.1890250411
bibo:pmid	2844987
has license	no-cc
sha1sum (hex)	d5e20770d66fcf8bed706305abf9f6e7f4d1a560
schema:url	https://doi.org/10.1002/jmv.1890250411
resource representing a document's title	Evaluation of an enzyme‐linked immunosorbent assay that measures rhinovirus‐specific antibodies in human sera and nasal secretions
has PubMed Central identifier	PMC7166658
has PubMed identifier	2844987
schema:publication	J Med Virol
resource representing a document's body	covid:d5e20770d66fcf8bed706305abf9f6e7f4d1a560#body_text
is schema:about of	named entity 'serum' named entity 'Antibodies' named entity 'THESE' named entity 'TYPE 2' named entity 'IS A' named entity 'STUDY' named entity 'RESULTS' named entity 'STRONG' named entity 'POST' named entity 'NASAL WASHINGS' named entity 'ANTIBODY' named entity 'CORRELATION' named entity 'RHINOVIRUS' named entity 'PRE' named entity 'ASSOCIATED WITH' named entity 'INFECTION' named entity 'DETECTED' named entity 'NEUTRALISING ANTIBODY' named entity 'illness' named entity 'antibody' named entity 'involving' named entity 'evaluation' named entity 'describe' named entity 'tested' named entity 'homologous' named entity 'serotype' named entity 'sera' named entity 'intranasally' named entity 'tissue culture' named entity 'antibodies' named entity 'HRV' named entity 'infection' named entity 'human rhinovirus' named entity 'nasal secretions' named entity 'antibody' named entity 'antibodies' named entity 'neutralising antibody' named entity 'infection' named entity 'antibodies' named entity 'type 2' named entity 'Human Sera' named entity 'IgA' named entity 'nutrient broth' named entity 'IgA' named entity 'IgA antibody' named entity 'colds' named entity 'IgA antibody' named entity 'HRV' named entity 'analysis of variance' named entity 'serum' named entity 'antibody' named entity 'HRV' named entity 'HRV' named entity 'tissue culture' named entity 'serotype' named entity 'p-nitrophenol' named entity 'HRV' named entity 'infection' named entity 'HRV' named entity 'serum' named entity 'rhinovirus' named entity 'homologous' named entity 'centrifuged' named entity 'colds' named entity 'rhinovirus' named entity 'rhinovirus' named entity 'infection' named entity 'high levels' named entity 'HRV' named entity 'antibody' named entity 'antibodies' named entity 'virus' named entity 'IgG' named entity 'subclinical' named entity 'carbonate' named entity 'inoculation' named entity 'antibody' named entity '5.0'

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