About: Transcriptome Analysis of the Initial Stage of Acute WSSV Infection Caused by Temperature Change

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About: Transcriptome Analysis of the Initial Stage of Acute WSSV Infection Caused by Temperature Change Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcriptome Analysis of the Initial Stage of Acute WSSV Infection Caused by Temperature Change
Creator	Zhang, X Li, F Li, S Sun, Y Sun, Z
Source	PMC
abstract	White spot syndrome virus (WSSV) is the most devastating virosis threatening the shrimp culture industry worldwide. Variations of environmental factors in shrimp culture ponds usually lead to the outbreak of white spot syndrome (WSS). In order to know the molecular mechanisms of WSS outbreak induced by temperature variation and the biological changes of the host at the initial stage of WSSV acute infection, RNA-Seq technology was used to analyze the differentially expressed genes (DEGs) in shrimp with a certain amount of WSSV cultured at 18°C and shrimp whose culture temperature were raised to 25°C. To analyze whether the expression changes of the DEGs were due to temperature rising or WSSV proliferation, the expression of selected DEGs was analyzed by real-time PCR with another shrimp group, namely Group T, as control. Group T didn’t suffer WSSV infection but was subjected to temperature rising in parallel. At the initial stage of WSSV acute infection, DEGs related to energy production were up-regulated, whereas most DEGs related to cell cycle and positive regulation of cell death and were down-regulated. Triose phosphate isomerase, enolase and alcohol dehydrogenase involved in glycosis were up-regulated, while pyruvate dehydrogenase, citrate synthase and isocitrate dehydrogenase with NAD as the coenzyme involved in TCA pathway were down-regulated. Also genes involved in host DNA replication, including DNA primase, DNA topoisomerase and DNA polymerase showed down-regulated expression. Several interesting genes including crustin genes, acting binding or inhibiting protein genes, a disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) gene and a GRP 78 gene were also analyzed. Understanding the interactions between hosts and WSSV at the initial stage of acute infection will not only help to get a deep insight into the pathogenesis of WSSV but also provide clues for therapies.
has issue date	2014-03-04(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0090732
bibo:pmid	24595043
has license	cc-by
sha1sum (hex)	d5cc1936183d8b73aa5006487dce09b3f8fe1d65
schema:url	https://doi.org/10.1371/journal.pone.0090732
resource representing a document's title	Transcriptome Analysis of the Initial Stage of Acute WSSV Infection Caused by Temperature Change
has PubMed Central identifier	PMC3942461
has PubMed identifier	24595043
schema:publication	PLoS One
resource representing a document's body	covid:d5cc1936183d8b73aa5006487dce09b3f8fe1d65#body_text
is schema:about of	named entity 'TRANSCRIPTOME ANALYSIS' named entity 'CRUSTIN' named entity 'PROLIFERATION' named entity 'PROVIDE' named entity 'DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9' named entity 'BIOLOGICAL' named entity 'VARIATIONS' named entity 'EXPRESSED' named entity 'USED' named entity 'GROUP' named entity 'CONTROL' named entity 'SELECTED' named entity 'CITRATE SYNTHASE' named entity 'UNDERSTANDING' named entity 'ANALYZED' named entity 'SYNDROME' named entity 'HOST' named entity 'GRP' named entity 'VIROSIS' named entity 'ENOLASE' named entity 'ALCOHOL DEHYDROGENASE' named entity 'NAD' named entity 'INSIGHT' named entity 'ISOCITRATE DEHYDROGENASE' named entity 'TEMPERATURE' named entity 'RELATED' named entity 'TCA' named entity 'TEMPERATURE CHANGE' named entity 'RAISED' named entity 'INTERACTIONS' named entity 'OUTBREAK' named entity 'SHRIMP CULTURE' named entity 'PARALLEL' named entity 'SUFFER' named entity 'A DISINTEGRIN AND METALLOPROTEINASE' named entity 'USUALLY' named entity 'INDUSTRY' named entity 'GENES' named entity 'GROUP T' named entity 'ENERGY PRODUCTION' named entity 'GENE' named entity 'BINDING' named entity 'WHITE SPOT' named entity 'PROTEIN ' named entity 'ORDER' named entity 'INVOLVED' named entity 'INTERESTING' named entity 'CELL CYCLE' named entity 'PYRUVATE DEHYDROGENASE' named entity 'CHANGES' named entity 'CULTURED' named entity 'TRIOSE PHOSPHATE ISOMERASE' named entity 'DUE TO' named entity 'CERTAIN' named entity 'WSSV' named entity 'REAL-TIME PCR ' named entity 'CULTURE' named entity 'ACUTE' named entity 'TECHNOLOGY' named entity 'INFECTION' named entity 'INITIAL STAGE' named entity 'INFECTION' named entity 'PONDS' named entity 'MECHANISMS' named entity 'BUT' named entity 'ENVIRONMENTAL FACTORS' named entity 'LEAD' named entity 'SHRIMP' named entity 'WHITE SPOT SYNDROME VIRUS' named entity 'DNA PRIMASE' named entity 'RNA-SEQ ' named entity 'INHIBITING' named entity 'EXPRESSION' named entity 'POSITIVE REGULATION OF CELL DEATH' named entity 'DNA REPLICATION' named entity 'THERAPIES' named entity 'DEGS'

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