About: Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses

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About: Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses
Creator	Cho, Won-Kyung Choi, Jang-Gi Hwang, Youn-Hwan Lee, Heeeun Lee, Jong-Soo Ma, Jin Rollinger, Judith Salgueiro, Ligia Tomczyk, Michał
Source	Medline; PMC
abstract	Eupatorium fortunei (EF) has long been used as herbal medicine in Korea, China, and Asian countries to treat a variety of diseases. Recent studies have reported that EF has anti-metastatic, anti-angiogenic, anti-bacterial, and anti-oxidant activities, as well as activities against malignant metastatic human cancers. The effect of EF and its components on viruses has not been reported. In the present study, the antiviral activity and mechanism of action of an aqueous extract of EF (WEF) and its components were evaluated in vitro. We found that pretreatment with WEF markedly reduced viral replication, as evaluated using a green fluorescent protein (GFP)-tagged virus (influenza A virus, Newcastle disease virus, and vesicular stomatitis virus) in murine RAW 264.7 macrophage cells. We demonstrated that WEF induces the production of type I IFN including pro-inflammatory cytokines. Additionally, we identified the active anti-viral components of WEF as quercetin, psoralen, and quercitrin. Thus, WEF and its active components are immunomodulators of the innate immune response in murine macrophages, a finding that is potentially useful to developing prophylactic or therapeutic treatments against a range of viruses.
has issue date	2017-08-03(xsd:dateTime)
bibo:doi	10.3389/fphar.2017.00511
bibo:pmid	28824435
has license	cc-by
sha1sum (hex)	d5a4d0cd6846bf609769f3274a5cbf22b11b14a5
schema:url	https://doi.org/10.3389/fphar.2017.00511
resource representing a document's title	Eupatorium fortunei and Its Components Increase Antiviral Immune Responses against RNA Viruses
has PubMed Central identifier	PMC5541272
has PubMed identifier	28824435
schema:publication	Front Pharmacol
resource representing a document's body	covid:d5a4d0cd6846bf609769f3274a5cbf22b11b14a5#body_text
is schema:about of	named entity 'COMPONENTS' named entity 'ANTIVIRAL' named entity 'EUPATORIUM FORTUNEI' named entity 'ASIAN COUNTRIES' named entity 'IDENTIFIED' named entity 'ITS' named entity 'USEFUL' named entity 'PROTEIN ' named entity 'INNATE IMMUNE RESPONSE' named entity 'CYTOKINES' named entity 'USING' named entity 'AQUEOUS EXTRACT' named entity 'IN VITRO' named entity 'PRESENT' named entity 'EUPATORIUM FORTUNEI' named entity 'DISEASES' named entity 'RECENT' named entity 'MURINE' named entity 'RAW 264.7' named entity 'IMMUNOMODULATORS' named entity 'IFN' named entity 'COMPONENTS' named entity 'VARIETY' named entity 'CHINA' named entity 'MALIGNANT' named entity 'GREEN FLUORESCENT PROTEIN' named entity 'VIRAL REPLICATION' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'USED' named entity 'ANTIVIRAL' named entity 'REDUCED' named entity 'STUDIES' named entity 'KOREA' named entity 'TAGGED' named entity 'DEMONSTRATED' named entity 'JOURNAL ' named entity 'PHARMACOLOGY' named entity 'OXIDANT' named entity 'LONG' named entity 'CELLS' named entity 'PRETREATMENT' named entity 'TREAT' named entity 'MARKEDLY' named entity 'VIRUSES' named entity 'ACTIVITIES' named entity 'ANTI-BACTERIAL' named entity 'TREATMENTS' named entity 'DEVELOPING' named entity 'ACTIVE' named entity 'PROPHYLACTIC' named entity 'PSORALEN' named entity 'ANTIVIRAL ACTIVITY' named entity 'IMMUNE RESPONSES' named entity 'RNA VIRUSES' named entity 'INCREASE' named entity 'SECTION' named entity 'ITS' named entity 'HUMAN' named entity 'FINDING' named entity 'HAVE' named entity 'EFFECT' named entity 'INFLAMMATORY' named entity 'HERBAL MEDICINE' named entity 'STUDY' named entity 'QUERCITRIN' named entity 'CANCERS' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'VIRUS' named entity 'EVALUATED' named entity 'PRO-' named entity 'REPORTED' named entity 'TYPE I' named entity 'INCLUDING'

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