About: Molecular Epidemiology of Human Rhinovirus in Children with Acute Respiratory Diseases in Chongqing, China

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About: Molecular Epidemiology of Human Rhinovirus in Children with Acute Respiratory Diseases in Chongqing, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Epidemiology of Human Rhinovirus in Children with Acute Respiratory Diseases in Chongqing, China
Creator	Cao, Wu-Chun Liu, Wei Lu, Qing-Bin Wang, Hong-Yu Wo, Ying Zhang, Xiao-Ai Huang, Dou-Dou Wang, Li-Yuan
Source	Medline; PMC
abstract	Human rhinovirus-C (HRV-C) has been increasingly detected in patients with acute respiratory diseases (ARDs). Prolonged surveillance was performed on children with ARD to investigate the molecular epidemiology and clinical characteristics of HRV in Chongqing, China. Nasopharyngeal aspirates (NPA) were collected from hospitalized children with ARD during 2009–2012. HRV-C was genotyped by sequencing the VP4/VP2 coding region. Among the 1,567 NPAs obtained, 223 (14.2%) were HRV positive, and 75.3% of these 223 NPAs were co-infected with other viruses. HRV-A (54.7%) and HRV-C (39.9%) accounted for the majority of HRV infections. Logistic regression models demonstrated significant associations between HRV-A, HRV-C, and asthma attacks, as well as between HRV-C and wheezing. A phylogenetic tree showed that HRV-C2 was the predominant type of HRV-C, followed by HRV-C43, HRV-C1, and HRV-C17. Three novel genotypes were proposed on the basis of a low identity with the known HRVs. Our results showed that HRV-A and HRV-C were the predominant types of HRV infection, and HRV-C showed a high genetic variation in Chongqing, China. HRV infection was associated with asthma attacks and wheezing; furthermore, HRV infections played a minor role in causing severe pneumonia. This knowledge provides information for the prevention and control of HRV associated with ARDs.
has issue date	2014-10-20(xsd:dateTime)
bibo:doi	10.1038/srep06686
bibo:pmid	25328042
has license	cc-by-nc-nd
sha1sum (hex)	d55c31191018d29b21fd07ed2c3a1c4b63dbe174
schema:url	https://doi.org/10.1038/srep06686
resource representing a document's title	Molecular Epidemiology of Human Rhinovirus in Children with Acute Respiratory Diseases in Chongqing, China
has PubMed Central identifier	PMC4202208
has PubMed identifier	25328042
schema:publication	Sci Rep
resource representing a document's body	covid:d55c31191018d29b21fd07ed2c3a1c4b63dbe174#body_text
is schema:about of	named entity 'ARD' named entity 'co-infected' named entity 'VP4' named entity 'asthma' named entity 'Chongqing' named entity 'GENOTYPES' named entity 'HRV' named entity 'INFORMATION' named entity 'VIRUSES' named entity 'majority' named entity 'ARDs' named entity 'high' named entity 'prevention' named entity 'causing' named entity 'control' named entity 'associations' named entity 'Rhinovirus' named entity 'infection' named entity 'HRV' named entity 'HRV' named entity 'viruses' named entity 'wheezing' named entity 'HRV' named entity 'HRV' named entity '2009-2012' named entity 'molecular epidemiology' named entity 'severe pneumonia' named entity 'HRV' named entity 'HRV' named entity 'coding region' named entity 'genotyped' named entity 'clinical characteristics' named entity 'Chongqing' named entity 'HRV' named entity 'HRV' named entity 'Lanzhou' named entity 'coinfection' named entity 'HRV' named entity 'viruses' named entity 'HRV' named entity '229E' named entity 'HRV' named entity 'asthma attacks' named entity 'laboratory analysis' named entity 'HRV' named entity 'HRV' named entity 'genetic variation' named entity 'serologically' named entity 'neighbor-joining method' named entity 'HRV' named entity 'genotypes' named entity 'humidity' named entity 'HRV' named entity 'HRV' named entity 'cough' named entity 'parainfluenza virus' named entity 'HRV' named entity 'laboratory tests' named entity 'study protocol' named entity 'HRV' named entity 'HRV' named entity 'ARD' named entity 'HRV' named entity 'retrospective study' named entity 'GenBank' named entity 'HRV' named entity 'HRV' named entity 'OC43' named entity 'HRV' named entity 'subtropical region' named entity 'HRV' named entity 'Chongqing Medical University' named entity 'HRV' named entity 'hypoxemia'

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