About: Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers

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About: Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers
Creator	Borisevich, Viktoriya Paessler, Slobodan Rijnbrand, Rene Blouch, Robert Dziuba, Natallia Ma, Yinghong Ni, Haolin Seregin, Alexey Yun, Nadezhda Iversen, Patrick Stein, David Zacks, Michele
source	Elsevier; Medline; PMC
abstract	The genus Alphavirus contains members that threaten human health, both as natural pathogens and as potential biological weapons. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) enter cells readily and can inhibit viral replication through sequence-specific steric blockade of viral RNA. Sindbis virus (SINV) has low pathogenicity in humans and is regularly utilized as a model alphavirus. PPMO targeting the 5′-terminal and AUG translation start site-regions of the SINV genome blocked the production of infectious SINV in tissue culture. PPMO designed against corresponding regions in Venezuelan equine encephalitis virus (VEEV) were likewise found to be effective in vitro against several strains of VEEV. Mice treated with PPMO before and after VEEV infection were completely protected from lethal outcome while mice receiving only post-infection PPMO treatment were partially protected. Levels of virus in tissue samples correlated with animal survival. Uninfected mice suffered no apparent ill-effects from PPMO treatment. Thus, PPMO appear promising as candidates for therapeutic development against alphaviruses.
has issue date	2008-07-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2008.03.032
bibo:pmid	18468653
has license	green-oa
sha1sum (hex)	d47b33faffe47a785f91a98de343a7748fef789e
schema:url	https://doi.org/10.1016/j.virol.2008.03.032
resource representing a document's title	Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers
has PubMed Central identifier	PMC2447162
has PubMed identifier	18468653
schema:publication	Virology
resource representing a document's body	covid:d47b33faffe47a785f91a98de343a7748fef789e#body_text
is schema:about of	named entity 'animal' named entity 'development' named entity 'site' named entity 'mice' named entity 'virus' covid:arg/d47b33faffe47a785f91a98de343a7748fef789e named entity 'pathogens' named entity 'blocked' named entity 'tissue' named entity 'completely' named entity 'samples' named entity 'viral replication' named entity 'regularly' named entity 'production' named entity 'start' named entity 'targeting' named entity 'candidates' named entity 'infection' named entity 'mice' named entity 'Venezuelan equine encephalitis virus' named entity 'VEEV' named entity 'SINV' named entity 'VEEV' named entity 'steric' named entity 'oligomers' named entity 'randomly selected' named entity 'human rhinovirus' named entity 'luciferase' named entity 'supportive treatment' named entity 'Venezuelan equine encephalitis virus' named entity 'pairwise comparison' named entity 'SINV' named entity 'VEEV' named entity 'hpi' named entity 'logrank test' named entity 'NIH' named entity 'intravenous injection' named entity 'virus' named entity 'antisense therapeutic' named entity 'infection' named entity 'maximum difference' named entity 'polyprotein' named entity 'mRNA' named entity 'Venezuelan equine encephalitis virus' named entity 'infection' named entity 'negative-strand' named entity 'BHK' named entity 'VEEV' named entity 'SINV' named entity 'VSV' named entity 'encephalitic' named entity 'Coronavirus' named entity 'Sindbis virus' named entity 'infection' named entity 'peptide' named entity 'VSV' named entity 'SINV' named entity 'Venezuelan equine encephalitis virus' named entity 'Venezuelan equine encephalitis virus' named entity 'plaque assay' named entity 'GraphPad Prism' named entity 'Venezuelan equine encephalitis virus' named entity 'highly conserved sequence' named entity 'virus' named entity 'BHK' named entity 'liver' named entity 'siRNA' named entity 'genome' named entity 'positive-stranded' named entity 'statistically significant'

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