About: A family cluster of three confirmed cases infected with avian influenza A (H7N9) virus in Zhejiang Province of China

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About: A family cluster of three confirmed cases infected with avian influenza A (H7N9) virus in Zhejiang Province of China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A family cluster of three confirmed cases infected with avian influenza A (H7N9) virus in Zhejiang Province of China
Creator	Yu, Hongjie Chen, Enfu Liu, Shelan Horby, Peter Chen, Yin Qin, Shuwen Yu, Zhao Mao, Haiyan Ding, Hua Yang, Xuhui Chai, Chengliang Hu, Jingfeng Wang, Fenjuan
Source	PMC
abstract	BACKGROUND: A total of 453 laboratory-confirmed cases infected with avian influenza A (H7N9) virus (including 175 deaths) have been reported till October 2,2014, of which 30.68% (139/453) of the cases were identified from Zhejiang Province. We describe the largest reported cluster of virologically confirmed H7N9 cases, comprised by a fatal Index case and two mild secondary cases. METHODS: A retrospective investigation was conducted in January of 2014. Three confirmed cases, their close contacts, and relevant environments samples were tested by real-time reverse transcriptase-polymerase chain reaction (RT-PCR), viral culture, and sequencing. Serum samples were tested by haemagglutination inhibition (HI) assay. RESULTS: The Index case, a 49-year-old farmer with type II diabetes, who lived with his daughter (Case 2, aged 24) and wife (Case 3, aged 43) and his son-in-law (H7N9 negative). The Index case and Case 3 worked daily in a live bird market. Onset of illness in Index case occurred in January 13, 2014 and subsequently, he died of multi-organ failure on January 20. Case 2 presented with mild symptoms on January 20 following frequent unprotected bed-side care of the Index case between January 14 to 19, and exposed to live bird market on January 17. Case 3 became unwell on January 23 after providing bedside care to the Index case on January 17 to 18, and following the contact with Case 2 during January 21 to 22 at the funeral of the Index case. The two secondary cases were discharged on February 2 and 5 separately after early treatment with antiviral medication. Four virus strains were isolated and genome analyses showed 99.6 ~100% genetic homology, with two amino mutations (V192I in NS and V280A in NP). 42% (11/26) of environmental samples collected in January were H7N9 positive. Twenty-five close contacts remained well and were negative for H7N9 infection by RT-PCR and HI assay. CONCLUSIONS: In the present study, the Index case was infected from a live bird market while the two secondary cases were infected by the Index case during unprotected exposure. This family cluster is, therefore, compatible with non-sustained person-to-person transmission of avian influenza A/H7N9. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-014-0698-6) contains supplementary material, which is available to authorized users.
has issue date	2014-12-31(xsd:dateTime)
bibo:doi	10.1186/s12879-014-0698-6
bibo:pmid	25551435
has license	cc-by
sha1sum (hex)	d46d01cc6e2316f71ee41ff731534ba2e43b8b29
schema:url	https://doi.org/10.1186/s12879-014-0698-6
resource representing a document's title	A family cluster of three confirmed cases infected with avian influenza A (H7N9) virus in Zhejiang Province of China
has PubMed Central identifier	PMC4304124
has PubMed identifier	25551435
schema:publication	BMC Infect Dis
resource representing a document's body	covid:d46d01cc6e2316f71ee41ff731534ba2e43b8b29#body_text
is schema:about of	named entity 'cases' named entity 'cases' named entity 'mild' named entity 'Zhejiang Province' named entity 'virus' named entity 'confirmed cases' named entity 'H7N9' named entity 'saccharides' named entity 'Human infection' named entity 'virus' named entity 'H7N9' named entity 'infection' named entity 'CDC' named entity 'H7N9' named entity 'genome sequences' named entity 'Index case' named entity 'H7N9' named entity 'H5N1' named entity 'January 19' named entity 'pneumonia' named entity 'January 20' named entity 'Zhejiang Province' named entity 'avian influenza virus' named entity 'mouse models' named entity 'virus' named entity 'H7N9' named entity 'human infection' named entity 'nucleic acid' named entity 'serum samples' named entity 'gene' named entity 'H7N9' named entity 'receptor' named entity 'H7N9' named entity 'Epidemiological' named entity 'China' named entity 'H7N9' named entity 'H7N9' named entity 'Xiaoshan' named entity 'mammals' named entity 'February 2' named entity 'influenza' named entity 'domestic animals' named entity 'infection' named entity 'infection' named entity 'personal protective equipment' named entity 'Zhejiang' named entity 'Index case' named entity 'homologous' named entity 'January 17' named entity 'antibodies' named entity 'clinical data' named entity 'anti-viral therapy' named entity 'February 4' named entity 'Guangdong' named entity 'Oseltamivir' named entity '0.04%' named entity 'CDC' named entity 'respiratory illness' named entity 'virus' named entity 'Jiangsu' named entity 'serum' named entity 'Index case' named entity 'H7N9' named entity 'risk assessment' named entity 'chemoprophylaxis' named entity 'GenBank' named entity 'vaccine' named entity 'amino acid' named entity 'personal protective equipment'

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