About: The human Cas1 protein: A sialic acid-specific O-acetyltransferase?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The human Cas1 protein: A sialic acid-specific O-acetyltransferase?
Creator	Schauer, Roland Vlasak, Reinhard Vilas, Ulrike Mayr, Juliane Merling, Anette »more»
source	Medline; PMC
abstract	Sialic acids are important sugars at the reducing end of glycoproteins and glycolipids. They are among many other functions involved in cell–cell interactions, host–pathogen recognition and the regulation of serum half-life of glycoproteins. An important modification of sialic acids is O-acetylation, which can alter or mask the biological properties of the parent sialic acid molecule. The nature of mammalian sialate-O-acetyltransferases (EC 2.3.1.45) involved in their biosynthesis is still unknown. We have identified the human CasD1 (capsule structure1 domain containing 1) gene as a candidate to encode the elusive enzyme. The human CasD1 gene encodes a protein with a serine–glycine–asparagine–histidine hydrolase domain and a hydrophobic transmembrane domain. Expression of the Cas1 protein tagged with enhanced green fluorescent protein in mammalian and insect cells directed the protein to the medial and trans-cisternae of the Golgi. Overexpression of the Cas1 protein in combination with α-N-acetyl-neuraminide α-2,8-sialyltransferase 1 (GD3 synthase) resulted in an up to 40% increased biosynthesis of 7-O-acetylated ganglioside GD3. By quantitative real-time polymerase chain reaction, we found up to 5-fold increase in CasD1 mRNA in tumor cells overexpressing O-Ac-GD3. CasD1-specific small interfering RNA reduced O-acetylation in tumor cells. These results suggest that the human Cas1 protein is directly involved in O-acetylation of α2-8-linked sialic acids.
has issue date	2010-10-14(xsd:dateTime)
bibo:doi	10.1093/glycob/cwq153
bibo:pmid	20947662
has license	no-cc
sha1sum (hex)	d43c56ffd7f500a0b5e681df1a83a9c4e7f1818a
schema:url	https://doi.org/10.1093/glycob/cwq153
resource representing a document's title	The human Cas1 protein: A sialic acid-specific O-acetyltransferase?
has PubMed Central identifier	PMC7108626
has PubMed identifier	20947662
schema:publication	Glycobiology
resource representing a document's body	covid:d43c56ffd7f500a0b5e681df1a83a9c4e7f1818a#body_text
is schema:about of	named entity 'HUMAN' named entity 'PROTEIN' named entity 'SIALIC ACID' named entity 'ACETYLTRANSFERASE' named entity 'SPECIFIC' »more»

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