About: Calming Cytokine Storm in Pneumonia by Targeted Delivery of TPCA-1 Using Platelet-derived Extracellular Vesicles

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Calming Cytokine Storm in Pneumonia by Targeted Delivery of TPCA-1 Using Platelet-derived Extracellular Vesicles
Creator	Wang, Chao Liu, Zhuang Gu, Zhen Fan, Qin Han, Xiao Bai, Jinyu Dong, Ziliang Ma, Qingle Wang, Gu Xu, Jialu Zhou, Xiaozhong
Source	Elsevier; Medline; PMC
abstract	Summary Pneumonia can cause high morbidity and mortality due to the uncontrolled inflammation in the lung tissue. Calming the cytokine storm may be one key to save the life of patients with severe pneumonia. Here, inspired by the intrinsic affinity of platelets to the site of inflammation, we have engineered platelet-derived extracellular vesicles (PEVs) for pneumonia-targeted drug delivery. It is demonstrated that PEVs that are easily generated from the activated platelets can selectively target pneumonia in the mice model with acute lung injury (ALI). By loading with [5-(p-Fluorophenyl)-2-ureido] thiophene-3-carboxamide (TPCA-1) that can inhibit the production of inflammatory factors, the PEVs significantly improve therapeutic benefits by inhibiting the pulmonary inflammatory cells infiltration, and calming local cytokine storm compared with the free drug-treated group. Furthermore, we find that PEVs could serve as a broad platform that can selectively target various inflammatory sites, including chronic atherosclerotic plaque, rheumatoid arthritis and wound associated with skin.
has issue date	2020-05-22(xsd:dateTime)
bibo:doi	10.1016/j.matt.2020.05.017
bibo:pmid	32835220
has license	els-covid
sha1sum (hex)	d3c88dbf8c201937db784f9cc2263a047c2e4723
schema:url	https://doi.org/10.1016/j.matt.2020.05.017
resource representing a document's title	Calming Cytokine Storm in Pneumonia by Targeted Delivery of TPCA-1 Using Platelet-derived Extracellular Vesicles
has PubMed Central identifier	PMC7242942
has PubMed identifier	32835220
schema:publication	Matter
resource representing a document's body	covid:d3c88dbf8c201937db784f9cc2263a047c2e4723#body_text
is schema:about of	named entity 'thiophene' named entity 'patients' named entity 'chronic' named entity 'infiltration' named entity 'therapeutic benefits' named entity 'ALI' named entity 'uncontrolled' named entity 'group' named entity 'inflammation' named entity 'high' named entity 'inflammatory cells' named entity 'drug delivery' named entity 'atherosclerotic plaque' named entity 'platform' named entity 'pneumonia' named entity 'TPCA' named entity 'target' named entity 'inflammatory' named entity 'Pneumonia' named entity 'targeted drug delivery' named entity 'lung tissue' named entity 'atherosclerotic plaque' named entity 'ALI' named entity 'platelets' named entity 'TPCA' named entity 'Platelet' named entity 'platelet' named entity 'disease models' named entity 'fluorescence' named entity 'atherosclerotic plaque' named entity 'immune cells' named entity 'PGE1' named entity 'immune response' named entity 'delivery systems' named entity 'lungs' named entity 'lung tissue' named entity 'CD40L' named entity 'cytokine storm' named entity 'histamine' named entity 'cytokine storms' named entity 'TEM' named entity 'acute lung injury' named entity 'macrophages' named entity 'IL-6 receptor' named entity 'platelets' named entity 'nano-sized' named entity 'enzyme-linked immunosorbent assay' named entity 'anti-inflammatory drug' named entity 'inflammation' named entity 'coronavirus' named entity 'inflammation' named entity 'platelets' named entity 'anti-inflammatory' named entity 'inflammation' named entity 'IL-6' named entity 'ROS' named entity 'ALI' named entity 'dynamic light scattering' named entity 'inflammatory cells' named entity 'pneumonia' named entity 'ALI' named entity 'rheumatoid arthritis' named entity 'Platelets' named entity 'Inflammation' named entity 'SARS-CoV-2' named entity 'lung tissue' named entity 'pneumonia' named entity 'LPS' named entity 'LPS' named entity 'Inflammation' named entity 'post hoc test'

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