About: Delivery Systems for Intradermal Vaccination

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Delivery Systems for Intradermal Vaccination
Creator	Kim, Y Jarrahian, C Mitragotri, S Prausnitz, M Prausnitz, Á Zehrung, D Zehrung, Á
source	PMC
abstract	Intradermal (ID) vaccination can offer improved immunity and simpler logistics of delivery, but its use in medicine is limited by the need for simple, reliable methods of ID delivery. ID injection by the Mantoux technique requires special training and may not reliably target skin, but is nonetheless used currently for BCG and rabies vaccination. Scarification using a bifurcated needle was extensively used for smallpox eradication, but provides variable and inefficient delivery into the skin. Recently, ID vaccination has been simplified by introduction of a simple-to-use hollow microneedle that has been approved for ID injection of influenza vaccine in Europe. Various designs of hollow microneedles have been studied preclinically and in humans. Vaccines can also be injected into skin using needle-free devices, such as jet injection, which is receiving renewed clinical attention for ID vaccination. Projectile delivery using powder and gold particles (i.e., gene gun) have also been used clinically for ID vaccination. Building off the scarification approach, a number of preclinical studies have examined solid microneedle patches for use with vaccine coated onto metal microneedles, encapsulated within dissolving microneedles or added topically to skin after microneedle pretreatment, as well as adapting tattoo guns for ID vaccination. Finally, technologies designed to increase skin permeability in combination with a vaccine patch have been studied through the use of skin abrasion, ultrasound, electroporation, chemical enhancers, and thermal ablation. The prospects for bringing ID vaccination into more widespread clinical practice are encouraging, given the large number of technologies for ID delivery under development.
has issue date	2011-04-07(xsd:dateTime)
bibo:doi	10.1007/82_2011_123
bibo:pmid	21472533
has license	no-cc
sha1sum (hex)	d36f86b21b3eb024c83ffa1d68b49663258d896f
schema:url	https://doi.org/10.1007/82_2011_123
resource representing a document's title	Delivery Systems for Intradermal Vaccination
has PubMed Central identifier	PMC3173582
has PubMed identifier	21472533
schema:publication	Intradermal Immunization
resource representing a document's body	covid:d36f86b21b3eb024c83ffa1d68b49663258d896f#body_text
is schema:about of	named entity 'VARIOUS' named entity 'EUROPE' named entity 'NEEDLE' named entity 'METHODS' named entity 'SKIN' named entity 'LOGISTICS' named entity 'TECHNIQUE' named entity 'USE' named entity 'RECENTLY' named entity 'EXAMINED' named entity '28I' named entity 'JET INJECTION' named entity 'improved' named entity 'skin' named entity 'ADDED' named entity 'NUMBER OF' named entity 'SMALLPOX' named entity 'FREE' named entity 'SIMPLE' named entity 'INTRADERMAL VACCINATION' named entity 'OFFER' named entity 'MICRONEEDLE' named entity 'METAL' named entity 'MANTOUX' named entity 'INTRODUCTION' named entity 'TOPICALLY' named entity 'RABIES VACCINATION' named entity 'HUMANS' named entity 'SPECIAL' named entity 'NEED FOR' named entity 'HOLLOW' named entity 'GOLD' named entity 'GENE' named entity 'PARTICLES' named entity 'APPROVED' named entity 'RECEIVING' named entity 'DEVICES' named entity 'APPROACH' named entity 'VACCINE' named entity 'POWDER' named entity 'BUILDING' named entity 'IMMUNITY' named entity 'VACCINATION' named entity 'PROVIDES' named entity 'PRECLINICAL STUDIES' named entity 'CURRENTLY' named entity 'INJECTION' named entity 'BUT' named entity 'LIMITED BY' named entity 'RELIABLE' named entity 'USED' named entity 'ERADICATION' named entity 'BIFURCATED' named entity 'USING' named entity 'TARGET' named entity 'DELIVERY SYSTEMS' named entity 'INEFFICIENT' named entity 'ENCAPSULATED' named entity 'VARIABLE' named entity 'BCG' named entity 'SOLID' named entity 'VACCINES' named entity 'INFLUENZA VACCINE' named entity 'TRAINING' named entity 'HAVE' named entity 'DELIVERY' named entity 'DISSOLVING' named entity 'COATED' named entity 'GUN' named entity 'ITS' named entity 'MEDICINE' named entity 'INTRADERMAL' named entity 'ATTENTION' named entity 'IMPROVED' named entity 'SCARIFICATION'

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