About: Challenges in the Etiology and Diagnosis of Acute Febrile Illness in Children in Low- and Middle-Income Countries

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Challenges in the Etiology and Diagnosis of Acute Febrile Illness in Children in Low- and Middle-Income Countries
Creator	Storch, Gregory Obaro, Stephen Tam, Pui-Ying
Source	PMC
abstract	Acute febrile illness is a common cause of hospital admission, and its associated infectious causes contribute to substantial morbidity and death among children worldwide, especially in low- and middle-income countries. Declining transmission of malaria in many regions, combined with the increasing use of rapid diagnostic tests for malaria, has led to the increasing recognition of leptospirosis, rickettsioses, respiratory viruses, and arboviruses as etiologic agents of fevers. However, clinical discrimination between these etiologies can be difficult. Overtreatment with antimalarial drugs is common, even in the setting of a negative test result, as is overtreatment with empiric antibacterial drugs. Viral etiologies remain underrecognized and poorly investigated. More-sensitive diagnostics have led to additional dilemmas in discriminating whether a positive test result reflects a causative pathogen. Here, we review and summarize the current epidemiology and focus particularly on children and the challenges for future research.
has issue date	2016-04-07(xsd:dateTime)
bibo:doi	10.1093/jpids/piw016
bibo:pmid	27059657
has license	no-cc
sha1sum (hex)	d3190987bc5652f06af34fb5a067af30427a32cc
schema:url	https://doi.org/10.1093/jpids/piw016
resource representing a document's title	Challenges in the Etiology and Diagnosis of Acute Febrile Illness in Children in Low- and Middle-Income Countries
has PubMed Central identifier	PMC7107506
has PubMed identifier	27059657
schema:publication	J Pediatric Infect Dis Soc
resource representing a document's body	covid:d3190987bc5652f06af34fb5a067af30427a32cc#body_text
is schema:about of	named entity 'DIAGNOSIS' named entity 'CONTRIBUTE ' named entity 'FOCUS' named entity 'RESPIRATORY VIRUSES' named entity 'DEATH' named entity 'ARBOVIRUSES' named entity 'TRANSMISSION' named entity 'RICKETTSIOSES' named entity 'INCOME' named entity 'HOSPITAL ADMISSION' named entity 'REFLECTS' named entity 'PATHOGEN' named entity 'RECOGNITION' named entity 'MORBIDITY' named entity 'POORLY' named entity 'VIRAL' named entity 'ACUTE FEBRILE ILLNESS' named entity 'INCREASING' named entity 'CLINICAL' named entity 'CAUSE' named entity 'LEPTOSPIROSIS' named entity 'RAPID' named entity 'DIFFICULT' named entity 'ETIOLOGY' named entity 'CHILDREN' named entity 'REGIONS' named entity 'INCOME' named entity 'COUNTRIES' named entity 'LOW' named entity 'MIDDLE' named entity 'WORLDWIDE' named entity 'ITS' named entity 'DIAGNOSTICS' named entity 'ACUTE FEBRILE ILLNESS' named entity 'CURRENT' named entity 'USE OF' named entity 'COMBINED' named entity 'FEVERS' named entity 'ANTIMALARIAL DRUGS' named entity 'IS A' named entity 'MALARIA' named entity 'LED' named entity 'MIDDLE' named entity 'EPIDEMIOLOGY' named entity 'ANTIBACTERIAL DRUGS' named entity 'FUTURE' named entity 'COUNTRIES' named entity 'DECLINING' named entity 'THESE' named entity 'POSITIVE TEST RESULT' named entity 'CHALLENGES' named entity 'DIAGNOSTIC TESTS' named entity 'REVIEW' named entity 'EMPIRIC' named entity 'INVESTIGATED' named entity 'ADDITIONAL' named entity 'ASSOCIATED' named entity 'INFECTIOUS' named entity 'CHILDREN' named entity 'DISCRIMINATION' named entity 'NEGATIVE TEST RESULT' named entity 'A COMMON' named entity 'CHALLENGES' named entity 'COMMON' named entity 'HAVE' named entity 'SETTING' named entity 'RESEARCH' named entity 'LOW' named entity 'CAUSES' named entity 'HERE' named entity 'malaria' named entity 'malaria' named entity 'Overtreatment' named entity 'middle-income' named entity 'viruses' named entity 'etiologies' named entity 'Etiology' named entity 'dengue' named entity 'malaria'

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