About: Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model
Creator	Loftsson, Thorsteinn Bodor5, Nicolas Brey6, Wallace Houck1, Herbert Koussi5, Alaeldin Raad2, Issam Rand, Kenneth Rand1v2, Kenneth Rocca6, James
Source	Elsevier; Medline; PMC
abstract	Abstract Trifluorothymidine (TFT) is known to be concentrated in herpes simplex virus (HSV) infected cells in vitro in the form of phosphorylated derivatives. We studied a murine hepatitis model of HSV infection to determine whether this in vitro observation would also be demonstrable in vivo. Following i.v. injection of 100 or 160 mg/kg TFT, TFT was found in significantly higher concentrations in the livers of HSV-2 infected mice than in the livers of uninfected mice, mice infected with murine hepatitis virus (MHV-A59) or mice with hepatitis from carbon tetrachloride treatment. Neither altered renal function, nor altered pharmacokinetics could account for this difference. 19F Nuclear Magnetic Resonance spectroscopy readily detected the 19F from TFT in both liver extracts and whole livers, particularly at higher tissue levels, i.e. > 50 μg/g tissue. If further studies with living animals support these preliminary observations, clinical application could be pursued.
has issue date	1987-12-31(xsd:dateTime)
bibo:doi	10.1016/0166-0934(87)90087-5
bibo:pmid	2832432
has license	els-covid
sha1sum (hex)	d2f61a07f7b47d65117fd3087aeb9f3a065c23d7
schema:url	https://doi.org/10.1016/0166-0934%2887%2990087-5
resource representing a document's title	Trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19F nuclear magnetic resonance in a murine hepatitis model
has PubMed Central identifier	PMC7119731
has PubMed identifier	2832432
schema:publication	Journal of Virological Methods
resource representing a document's body	covid:d2f61a07f7b47d65117fd3087aeb9f3a065c23d7#body_text
is schema:about of	named entity 'pursued' named entity 'mice' named entity 'herpes simplex virus (HSV)' named entity 'account' named entity 'NUCLEAR MAGNETIC RESONANCE' named entity 'INJECTION' named entity 'TFT' named entity 'TFI' named entity 'LEVELS' named entity 'INFECTED' named entity 'LIVERS' named entity 'COULD BE' named entity '160' named entity 'NEITHER' named entity 'OBSERVATION' named entity 'HSV-2' named entity 'TREATMENT' named entity 'TRIFLUOROTHYMIDINE' named entity 'HERPES SIMPLEX VIRUS' named entity 'MICE' named entity 'LIVING' named entity 'CELLS' named entity 'OBSERVATIONS' named entity 'NON-INVASIVE DIAGNOSIS' named entity 'MURINE HEPATITIS' named entity 'HERPES SIMPLEX INFECTION' named entity 'POTENTIAL' named entity 'MODEL' named entity 'MODEL OF' named entity 'ALTERED' named entity 'CARBON TETRACHLORIDE' named entity '19F NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY' named entity 'CONCENTRATED' named entity 'CLINICAL APPLICATION' named entity 'MG%' named entity 'DEMONSTRABLE' named entity 'USING' named entity 'DIFFERENCE' named entity 'HIGHER' named entity 'STUDIES' named entity 'DETECTED' named entity 'PRELIMINARY' named entity 'RENAL FUNCTION' named entity 'ACCOUNT' named entity 'FOUND' named entity 'A59' named entity 'FORM' named entity 'MURINE HEPATITIS VIRUS' named entity 'IN VIVO' named entity 'FOLLOWING' named entity 'UNINFECTED' named entity 'DETERMINE' named entity '100' named entity 'HSV INFECTION' named entity 'PHARMACOKINETICS' named entity 'MURINE HEPATITIS' named entity 'IN VITRO' named entity 'HEPATITIS' named entity 'CONCENTRATIONS' named entity 'ANIMALS' named entity 'THESE' named entity 'PHOSPHORYLATED' named entity 'TISSUE' named entity 'SUPPORT' named entity 'KNOWN' named entity 'LIVER EXTRACTS' covid:arg/d2f61a07f7b47d65117fd3087aeb9f3a065c23d7 named entity 'carbon tetrachloride' named entity 'i.v.' named entity 'concentrated' named entity 'murine' named entity 'vivo' named entity 'tissue'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software