About: A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3

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About: A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3
Creator	Pastey, Manoj Spearman, Paul Crowe, James Gower, Tara Graham, Barney
Source	Medline; PMC
abstract	The fusion glycoproteins of human respiratory syncytial virus (RSV) and human parainfluenza virus type-3 (PIV-3) mediate virus entry and syncytium formation. Interaction between the fusion protein of RSV and RhoA, a small GTPase, facilitates virus-induced syncytium formation. We show here a RhoA-derived peptide inhibits RSV and syncytium formation induced by RSV and PIV-3, both in vitro by inhibition of cell-to-cell fusion and in vivo by reduction of peak titer by 2 log(10) in RSV-infected mice. These findings indicate that the interaction between these two paramyxovirus fusion proteins and RhoA is an important target for new antiviral strategies.
has issue date	2000-01-01(xsd:dateTime)
bibo:doi	10.1038/71503
bibo:pmid	10613821
has license	no-cc
sha1sum (hex)	d2c132e2a1ed115448ce81cc1bea9d502d51f497
schema:url	https://doi.org/10.1038/71503
resource representing a document's title	A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3
has PubMed Central identifier	PMC7095870
has PubMed identifier	10613821
schema:publication	Nat Med
resource representing a document's body	covid:d2c132e2a1ed115448ce81cc1bea9d502d51f497#body_text
is schema:about of	named entity 'induced' named entity 'DERIVED' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'SYNCYTIUM FORMATION' named entity 'PEPTIDE' named entity 'PARAINFLUENZA VIRUS TYPE 3' named entity 'INDUCED' named entity 'RHOA' named entity 'ARTICLES' covid:arg/d2c132e2a1ed115448ce81cc1bea9d502d51f497 named entity 'parainfluenza virus' named entity 'RhoA' named entity 'syncytium' named entity 'homologous' named entity 'glycoprotein' named entity 'FBS' named entity 'infection' named entity 'cell culture' named entity 'peptide' named entity 'RSV' named entity 'cellulose ester' named entity 'cytopathology' named entity 'PBS' named entity 'actin' named entity 'RSV infection' named entity 'RSV' named entity 'fusion proteins' named entity 'dialyzed' named entity 'absorbance' named entity 'cell culture' named entity 'weight loss' named entity 'supernatants' named entity 'mice' named entity 'vaccinia virus' named entity 'yeast two-hybrid assay' named entity 'RhoA' named entity 'virus' named entity 'RhoA' named entity 'mice' named entity 'RhoA' named entity 'similar function' named entity 'β-galactosidase' named entity 'vaccinia virus' named entity 'fusion protein' named entity 'RSV' named entity 'intranasally' named entity 'cell membrane' named entity 'protein' named entity 'sequence analysis' named entity 'RhoA' named entity 'RhoA' named entity 'recombinant' named entity 'amino acids' named entity 'syncytium' named entity 'RSV' named entity 'endoplasmic reticulum' named entity 'RhoA' named entity 'peptide' named entity 'peptide' named entity 'peptide' named entity 'antiviral therapy' named entity 'RhoA' named entity 'RhoA' named entity 'trypsinized' named entity 'peptide' named entity 'Rac1' named entity 'antigen' named entity 'cytoplasmic' named entity 'Roskilde' named entity 'peptide' named entity 'RhoA' named entity 'peptides' named entity 'pH 9' named entity 'RhoA' named entity 'virus-cell fusion' named entity 'RSV' named entity 'peptide'

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