About: Chapter 99 Ocular Mucosal Immunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chapter 99 Ocular Mucosal Immunity
Creator	Montgomery, Paul O'sullivan, Nancy
Source	Elsevier; PMC
abstract	Abstract Mucosal immunity defends the ocular surface against antigenic challenge and microbial invasion. The principal effector site is the lacrimal gland, where immunoglobulin A (IgA) antibodies are produced. Nasal-associated lymphoid tissue and posterior cervical lymph nodes function as major inductive sites for tear IgA responses. Neural connections and systemic hormones maintain the integrity and function of the ocular surface. Neuroenzyme activities in the lacrimal gland are influenced by ocular infections, leading to reduced expression of acetylcholine and modulation of receptors on acinar cells and on plasma cells, thereby decreasing fluid and immunoglobulin secretion. T lymphocyte-dependent responses result in production of interleukin-4 in lacrimal glands, thereby influencing cholinergic enzyme activity affecting immune processes and lacrimal physiology. Furthermore, neuropeptides released into lymphoid structures or inflamed tissues are chemotactic for antigen-presenting cells and affect their interactions with T cells. Thus, in developing therapeutic approaches for treating dry-eye conditions and vaccination strategies to elicit protective ocular mucosal immune responses, the entire lacrimal functional unit should be considered.
has issue date	2015-12-31(xsd:dateTime)
bibo:doi	10.1016/b978-0-12-415847-4.00099-9
has license	els-covid
sha1sum (hex)	d2b5d9c47be7ca6f4219635608f4382e948c96ab
schema:url	https://doi.org/10.1016/b978-0-12-415847-4.00099-9
resource representing a document's title	Chapter 99 Ocular Mucosal Immunity
has PubMed Central identifier	PMC7173532
schema:publication	Mucosal Immunology
resource representing a document's body	covid:d2b5d9c47be7ca6f4219635608f4382e948c96ab#body_text
is schema:about of	named entity 'Immunity' named entity 'Mucosal Immunity' named entity 'Mucosal' named entity 'IgA' named entity 'mammary gland' named entity 'Sjögren's syndrome' named entity 'tear film' named entity 'epithelium' named entity 'IgG' named entity 'chemokines' named entity 'infection' named entity 'monocyte' named entity 'aqueous' named entity 'Lacrimal glands' named entity 'lymphoid' named entity 'dendritic cells' named entity 'monomeric' named entity 'TNF' named entity 'midbrain' named entity 'lacrimal gland' named entity 'cell wall' named entity 'lamina propria' named entity 'mucin' named entity 'nasal-associated lymphoid tissue' named entity 'conjunctiva' named entity 'goblet cells' named entity 'lacrimal gland' named entity 'lymphoid tissues' named entity 'tear film' named entity 'bioactive' named entity 'tarsal plates' named entity 'immune responses' named entity 'lacrimal' named entity 'myoepithelial cells' named entity 'IgG' named entity 'secretion' named entity 'evaporation' named entity 'MUC5AC' named entity 'human cytomegalovirus' named entity 'viruses' named entity 'lacrimal' named entity 'muscarinic acetylcholine receptor' named entity 'acetylcholine' named entity 'skeletal structure' named entity 'IgD' named entity 'Pockley' named entity 'antigen' named entity 'immunology' named entity 'lacrimal gland' named entity 'lactoferrin' named entity 'mammalian species' named entity 'HIV' named entity 'eosinophils' named entity 'pathogens' named entity 'IgM' named entity 'acinar cells' named entity 'neurotransmitter' named entity 'APCs' named entity 'dendritic cell' named entity 'MUC16' named entity 'neuropeptides' named entity 'epidermal growth factor' named entity 'tear fluid' named entity 'cholinergic' named entity 'lysozyme' named entity 'esters' named entity 'stress response' named entity 'neuroendocrine' named entity 'lipids' named entity 'IgA' named entity 'mast cells' named entity 'leukocyte' named entity 'growth factors' named entity 'gastrointestinal tract' named entity 'tear film' named entity 'natural killer cells' named entity 'tear duct' named entity 'fungal infections' named entity 'immune response' named entity 'lacrimal gland' named entity 'enzyme activity' named entity 'IgA'

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