About: Canine distemper virus-induced depletion of uninfected lymphocytes is associated with apoptosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Canine distemper virus-induced depletion of uninfected lymphocytes is associated with apoptosis
Creator	Summerfield, Artur Griot, Christian Schobesberger, Martina Zurbriggen, Andreas Doherr, Marcus
Source	Elsevier; Medline; PMC
abstract	Abstract Canine distemper virus (CDV), a negative stranded RNA morbillivirus, causes a multisystemic disease in dogs, which is associated with a severe immune suppression. The aim of the study was to examine the influence of early CDV infection on leukocyte depletion, lymphopenia and virus-induced cell death in dogs infected with a virulent CDV strain. From 10 infected dogs, peripheral blood leukocytes were harvested periodically, phenotyped and analyzed for CDV antigen content and apoptosis using Annexin V-FITC and propidium iodide labeling. CDV infection induced a severe CD3+ T cell and CD21+ B cell depletion in all animals at 3 days post-infection (d.p.i.). For dogs with severe distemper, developing virus persistence in the lymphoid tissue and central nervous system, this lymphopenia lasted until the end of the experiment. Increased levels of lymphocyte apoptosis were found at 3 d.p.i., and monocyte apoptosis at 6 d.p.i. This was more prominent in the group of animals with severe distemper. At 3 d.p.i. no leukocyte infection was detectable indicating that the early lymphocyte depletion and apoptosis was not a direct consequence of virus infection. Taken together, our results demonstrate that CDV-induced lymphopenia is an early event and that the degree of lymphocyte depletion correlates with the severity of disease and virus persistence in the lymphoid tissue and central nervous system.
has issue date	2005-03-10(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2004.09.032
bibo:pmid	15661329
has license	els-covid
sha1sum (hex)	d29d59ba7423ce04d023131683ea6aeddb333afc
schema:url	https://doi.org/10.1016/j.vetimm.2004.09.032
resource representing a document's title	Canine distemper virus-induced depletion of uninfected lymphocytes is associated with apoptosis
has PubMed Central identifier	PMC7127010
has PubMed identifier	15661329
schema:publication	Veterinary Immunology and Immunopathology
resource representing a document's body	covid:d29d59ba7423ce04d023131683ea6aeddb333afc#body_text
is schema:about of	named entity 'ASSOCIATED WITH' named entity 'demonstrate' named entity 'dogs' named entity 'cell death' named entity 'degree' named entity 'propidium iodide' named entity 'dogs' named entity 'levels' named entity 'INFECTED' named entity 'MORBILLIVIRUS' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'DETECTABLE' named entity 'DISEASE' named entity 'ANTIGEN' named entity 'PERIPHERAL BLOOD' named entity 'EARLY' named entity 'DEGREE' named entity 'LYMPHOCYTE DEPLETION' named entity 'AIM' named entity 'ANNEXIN V-FITC' named entity 'DIRECT' named entity 'CANINE DISTEMPER VIRUS' named entity 'CONTENT' named entity 'CDV' named entity 'B CELL DEPLETION' named entity 'INDUCED' named entity 'CAUSES' named entity 'D.P.' named entity 'GROUP' named entity 'SEVERE' named entity 'LEVELS' named entity 'TAKEN' named entity 'LYMPHOCYTE APOPTOSIS' named entity 'EVENT' named entity 'INDICATING' named entity 'FOUND' named entity 'PROMINENT' named entity 'DEVELOPING' named entity 'DAYS' named entity 'ASSOCIATED WITH' named entity 'PROPIDIUM IODIDE' named entity 'CD21' named entity 'UNINFECTED' named entity 'LYMPHOCYTES' named entity 'APOPTOSIS' named entity 'LABELING' named entity 'INFLUENCE' named entity 'PERIODICALLY' named entity 'POST' named entity 'INDUCED' named entity 'APOPTOSIS' named entity 'LEUKOCYTE' named entity 'LYMPHOID TISSUE' named entity 'VIRUS INFECTION' named entity 'RESULTS' named entity 'STUDY' named entity 'CANINE DISTEMPER VIRUS' named entity 'DEPLETION' named entity 'SEVERITY' named entity 'MONOCYTE' named entity 'ANIMALS' named entity 'EXPERIMENT' named entity 'CONSEQUENCE OF' named entity 'VIRULENT' named entity 'DISTEMPER' named entity 'TO EXAMINE' named entity 'DEPLETION' named entity 'IMMUNE SUPPRESSION' named entity 'INFECTION' named entity 'USING' named entity 'VIRUS' named entity 'LYMPHOPENIA' named entity 'OUR' named entity 'T CELL' named entity 'DOGS' named entity 'ANALYZED' named entity 'END'

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