About: Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome

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About: Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome
Creator	Wang, Shuang Huang, Yuefang Liang, Yingjie Wang, Hongyue Yang, Niansheng Zhao, Jijun
Source	Elsevier; Medline; PMC
abstract	Abstract NLRP3 inflammasome is engaged in the inflammatory response during acute lung injury (ALI). Purinergic receptor P2X7 has been reported to be upstream of NLRP3 activation. However, the therapeutic implication of P2X7 in ALI remains to be explored. The present study used lipopolysaccharide (LPS)-induced mouse model to investigate the therapeutic potential of P2X7 blockage in ALI. Our results showed that P2X7/NLRP3 inflammasome pathway was significantly upregulated in the lungs of ALI mice as compared with control mice. P2X7 antagonist A438079 suppressed NLRP3/ASC/caspase 1 activation, production of IL-1β, IL-17A and IFN-γ and neutrophil infiltration but not the production of IL-10, resulting in a significant amelioration of lung injury. Moreover, blockage of P2X7 significantly inhibited NLRP3 inflammasome activation and IL-1β production in bone marrow derived macrophages. Similar results were obtained using another P2X7 inhibitor brilliant blue G (BBG) in vivo. Thus, pharmacological blockage of P2X7/NLRP3 pathway can be considered as a potential therapeutic strategy in patients with ALI.
has issue date	2015-07-31(xsd:dateTime)
bibo:doi	10.1016/j.intimp.2015.04.035
bibo:pmid	25937482
has license	els-covid
sha1sum (hex)	d2950aa976efd51c6690ed0a071947448837a8e6
schema:url	https://doi.org/10.1016/j.intimp.2015.04.035
resource representing a document's title	Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome
has PubMed Central identifier	PMC7185518
has PubMed identifier	25937482
schema:publication	International Immunopharmacology
resource representing a document's body	covid:d2950aa976efd51c6690ed0a071947448837a8e6#body_text
is schema:about of	named entity 'BLOCKAGE' named entity 'IL-1β' named entity 'inflammasome' named entity 'P2X7' named entity 'ALI' named entity 'patients' named entity 'study' named entity 'inhibited' named entity 'P2X7' named entity 'NLRP3' named entity 'PATHWAY' named entity 'NLRP3 INFLAMMASOME ACTIVATION' named entity 'PATIENTS' named entity 'INDUCED' named entity 'ACUTE LUNG INJURY' named entity 'THERAPEUTIC' named entity 'MACROPHAGES' named entity 'TO INVESTIGATE' named entity 'PHARMACOLOGICAL' named entity 'STRATEGY' named entity 'PURINERGIC RECEPTOR' named entity 'RESULTS' named entity 'IFN' named entity 'SIGNIFICANT' named entity 'CONSIDERED' named entity 'ACTIVATION' named entity 'THE LUNGS' named entity 'IL-10' named entity 'AMELIORATION' named entity 'OBTAINED' named entity 'OUR' named entity 'MOUSE MODEL' named entity 'UPREGULATED' named entity '10%' named entity 'REPORTED' named entity 'STUDY' named entity 'BUT' named entity 'UPSTREAM' named entity 'SIMILAR' named entity 'BONE MARROW' named entity 'ENGAGED' named entity 'LUNG INJURY' named entity 'DERIVED' named entity 'IN VIVO' named entity 'IL-1' named entity 'COMPARED' named entity 'BRILLIANT BLUE G' named entity 'POTENTIAL' named entity 'IL-17A' named entity 'INFLAMMASOME' named entity 'INHIBITING' named entity 'INFLAMMASOME' named entity 'ACUTE LUNG INJURY' named entity 'P2X7' named entity 'MICE' named entity 'NLRP3' named entity 'INHIBITED' named entity 'A438079' named entity 'PRODUCTION' named entity 'SUPPRESSED' named entity 'PRESENT' named entity 'INHIBITOR' named entity 'USED' named entity 'INFLAMMATORY RESPONSE' named entity 'LIPOPOLYSACCHARIDE' named entity 'ANTAGONIST' named entity 'USING' named entity 'RESULTING IN' named entity 'NLRP3' named entity 'CONTROL' named entity 'P2X7' named entity 'BLOCKAGE' named entity 'NEUTROPHIL INFILTRATION' named entity 'MICE' covid:arg/d2950aa976efd51c6690ed0a071947448837a8e6 named entity 'strategy'

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