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About:
Effect of statins on SARS-CoV-2 infection
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covidontheweb.inria.fr
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Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Effect of statins on SARS-CoV-2 infection
Creator
Brogden, Graham
Kluge, Stefan
Pietschmann, Thomas
Gerold, Gisa
Kirui, Jared
»more»
source
MedRxiv
abstract
The retrospective analysis of clinical data of patients suffering from COVID-19 has indicated that statin therapy, used to lower plasma cholesterol levels, is associated with a better clinical outcome. We therefore investigated the effect of statins on SARS-CoV-2 infection and found that selective statins reduced SARS-CoV-2 cell entry and inhibited high and low pathogenic coronavirus infection in human cells. A retrospective study on hospitalized patients with COVID-19 implies that reduced high density lipoprotein levels, which are typically counteracted by statin therapy, are associated with aggravated disease outcome. These results suggest that statin therapy poses no additional risk to individuals exposed to SARS-CoV-2 and that some statins may have a mild beneficial effect on COVID-19 outcome.
has issue date
2020-07-14
(
xsd:dateTime
)
bibo:doi
10.1101/2020.07.13.20152272
has license
medrxiv
sha1sum (hex)
d2898efc13e003ea8792d1c500d50f76d65de932
schema:url
https://doi.org/10.1101/2020.07.13.20152272
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Effect of statins on SARS-CoV-2 infection
resource representing a document's body
covid:d2898efc13e003ea8792d1c500d50f76d65de932#body_text
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schema:about
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named entity 'statins'
named entity 'recombinant'
named entity 'rosuvastatin'
named entity 'gene'
named entity 'COVID'
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