About: Chrysophyllum albidum (African star apple) fruit-supplemented diet enhances cognitive functions and attenuates lipopolysaccharide-induced memory impairment, oxidative stress, and release of proinflammatory cytokines

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About: Chrysophyllum albidum (African star apple) fruit-supplemented diet enhances cognitive functions and attenuates lipopolysaccharide-induced memory impairment, oxidative stress, and release of proinflammatory cytokines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chrysophyllum albidum (African star apple) fruit-supplemented diet enhances cognitive functions and attenuates lipopolysaccharide-induced memory impairment, oxidative stress, and release of proinflammatory cytokines
Creator	Ajayi, Abayomi Ben-Azu, Benneth Chidebe, Emmanuel Umukoro, Solomon
Source	PMC
abstract	PURPOSE: Fruit-based supplement has an important role in protecting the brain against oxido-inflammatory stress. Chrysophyllum albidum fruit contained several phytonutrients that possess antioxidants and anti-inflammatory properties. Hence, this study investigated the effect of C. albidum fruit supplemented diet (CAFD) on cognitive functions and lipopolysaccharide (LPS)-induced memory impairment and oxido-inflammatory response in mice. METHODS: Mice were randomized into two experiments. Experiment 1 with naïve mice contained four groups (n = 6) while experiment 2 with LPS contains five groups (n = 6). Mice in experiments 1 and 2 were fed on CAFD (5%, 10%, and 20%) in naïve (6 weeks) and LPS (250 μg/kg, i.p.) in the 7th week, respectively. Cognitive performance was tested using Y-maze test (YMT) and novel object recognition test (NORT) in the naïve and LPS mice. Brain samples were obtained for determination of oxido-inflammatory parameters and acetylcholinesterase activity. RESULTS: The CAFD significantly enhanced cognitive performance in the YMT and NORT in naïve and LPS mice, as evidenced by increased % alternation and discrimination index, respectively. CAFD supplementation significantly reduced acetylcholinesterase enzyme activity while it attenuated depletion of reduced glutathione and catalase activities in brains of naive and LPS-treated animals. The CAFD significantly reduced LPS-induced increased malondialdehyde levels in mice brains. CAFD supplementation significantly attenuated LPS-induced pro-inflammatory cytokines (IL-6, TNF-α) in mice brains. CONCLUSION: Chrysophyllum albidum fruit supplementation in diet enhances memory function and prevents cognitive deficits induced by LPS via mechanisms associated with inhibition of oxidative stress-related processes, acetylcholinesterase activity, and pro-inflammatory mediators.
has issue date	2020-08-26(xsd:dateTime)
bibo:doi	10.1186/s41110-020-00123-3
has license	no-cc
sha1sum (hex)	d25fd47153f738ea3c9879b0dc8277ab9a7ade1d
schema:url	https://doi.org/10.1186/s41110-020-00123-3
resource representing a document's title	Chrysophyllum albidum (African star apple) fruit-supplemented diet enhances cognitive functions and attenuates lipopolysaccharide-induced memory impairment, oxidative stress, and release of proinflammatory cytokines
has PubMed Central identifier	PMC7448960
schema:publication	Nutrire
resource representing a document's body	covid:d25fd47153f738ea3c9879b0dc8277ab9a7ade1d#body_text
is schema:about of	named entity 'randomized' named entity 'mice' named entity 'brains' named entity 'cognitive functions' named entity 'antioxidants' named entity 'determination' named entity 'mice' named entity 'cognitive deficits' named entity 'fruit' named entity 'memory' named entity 'oxidative stress' named entity 'PRO-' named entity 'TNF-' named entity 'CYTOKINES' named entity '7TH' named entity 'Experiment' named entity 'week' named entity 'reduced' named entity 'possess' named entity 'tested' named entity 'attenuated' named entity 'test' named entity 'Y-maze' named entity 'Mice' named entity 'brains' named entity 'enhanced' named entity 'test' named entity 'performance' named entity 'IL-6' named entity 'activity' named entity 'Mice' named entity 'catalase' named entity 'LPS' named entity 'acetylcholinesterase' named entity 'Y-maze' named entity 'anti-inflammatory' named entity 'mice' named entity 'cognitive functions' named entity 'LPS' named entity 'Mice' named entity 'IL-6' named entity 'mice' named entity 'acetylcholinesterase' named entity 'enzyme activity' named entity 'lipopolysaccharide' named entity 'cognitive functions' named entity 'inhibition' named entity 'NCDs' named entity 'C. albidum' named entity 'C. albidum' named entity 'μmol' named entity 'animal models' named entity 'LPS' named entity 'LPS' named entity 'acetylcholinesterase' named entity 'phenotypes' named entity 'Ibadan North' named entity 'India' named entity 'IL-6' named entity 'neuroinflammation' named entity 'LPS' named entity 'cholinergic activity' named entity 'one-way ANOVA' named entity 'neuroinflammation' named entity 'phosphoric acid' named entity 'TNF-α' named entity 'recognition memory' named entity 'one-way ANOVA' named entity 'TNF-α' named entity 'memory loss' named entity 'cognitive deficits' named entity 'LPS' named entity 'neuroinflammation' named entity 'age-related' named entity 'cholinergic' named entity 'memory loss' named entity 'Lipopolysaccharide' named entity 'LPS' named entity '85%' named entity 'Chrysophyllum albidum'

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