About: Bottlenecks in the transmission of porcine reproductive and respiratory syndrome virus (PRRSV1) to naïve pigs and the quasi-species variation of the virus during infection in vaccinated pigs

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Bottlenecks in the transmission of porcine reproductive and respiratory syndrome virus (PRRSV1) to naïve pigs and the quasi-species variation of the virus during infection in vaccinated pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Bottlenecks in the transmission of porcine reproductive and respiratory syndrome virus (PRRSV1) to naïve pigs and the quasi-species variation of the virus during infection in vaccinated pigs
Creator	Mateu, Enric Cortey, Martí Martín-Valls, Gerard Arocena, Gastón Pileri, Emanuela
source	Medline; PMC
abstract	This paper describes the results of two experiments regarding porcine reproductive and respiratory syndrome virus (PRRSV1): the first one studied the existence of bottlenecks in an experimental one-to-one model of transmission in pigs; while the second analysed the differences between viral quasi-species in vaccinated pigs that developed shorter or longer viraemias after natural challenge. Serum samples, as well as the initial inoculum, were deep-sequenced and a viral quasi-species was constructed per sample. For the first experiment, the results consistently reported a reduction in the quasi-species diversity after a transmission event, pointing to the existence of bottlenecks during PRRSV1 transmission. However, despite the identified preferred and un-preferred transmitted variants not being randomly distributed along the virus genome, it was not possible to identify any variant producing a structural change in any viral protein. In contrast, the mutations identified in GP2, nsp9 and M of the second experiment pointed to changes in the amino acid charges and the viral RNA-dependent RNA polymerase structure. The fact that the affected proteins are known targets of the immunity against PRRSV, plus the differential level of neutralizing antibodies present in pigs developing short or long viraemias, suggests that the immune response selected those changes.
has issue date	2018-10-19(xsd:dateTime)
bibo:doi	10.1186/s13567-018-0603-1
bibo:pmid	30340626
has license	cc-by
sha1sum (hex)	d254df02d28dea4fa83cd865d07aff67d13c5d3f
schema:url	https://doi.org/10.1186/s13567-018-0603-1
resource representing a document's title	Bottlenecks in the transmission of porcine reproductive and respiratory syndrome virus (PRRSV1) to naïve pigs and the quasi-species variation of the virus during infection in vaccinated pigs
has PubMed Central identifier	PMC6389235
has PubMed identifier	30340626
schema:publication	Vet Res
resource representing a document's body	covid:d254df02d28dea4fa83cd865d07aff67d13c5d3f#body_text
is schema:about of	named entity 'For' named entity 'studied' named entity 'bottlenecks' named entity 'RNA-dependent RNA polymerase' named entity 'transmission' named entity 'producing' named entity 'viral' named entity 'structure' named entity 'bottlenecks' named entity 'reproductive' named entity 'REDUCTION' named entity 'EXPERIMENTAL' named entity 'CHALLENGE' named entity 'VIRUS' named entity 'DIFFERENTIAL' named entity 'LEVEL' named entity 'MODEL OF' named entity 'SPECIES DIVERSITY' named entity 'PREFERRED' named entity 'VARIANT' named entity 'vaccinated' named entity 'proteins' named entity 'virus' named entity 'viral protein' named entity 'constructed' named entity 'level' named entity 'structural change' named entity 'immune response' named entity 'preferred' named entity 'infection' named entity 'Bottlenecks' named entity 'founder population' named entity 'amino acid' named entity 'immune response' named entity 'Gly' named entity 'Asp' named entity '260 nm and 280 nm' named entity 'Asp' named entity 'cell receptor' named entity 'RdRp' named entity 'nsp4' named entity 'nsp5' named entity 'nucleotide' named entity 'qRT-PCR' named entity 'amino acid' named entity 'amino acid' named entity 'RNA' named entity 'viraemia' named entity 'genome' named entity 'Arteriviridae' named entity 'viruses' named entity 'amino acid' named entity 'nucleotide diversity' named entity 'viral genome' named entity 'Cell culture' named entity 'cell receptor' named entity 'genetic diversity' named entity 'protein' named entity 'viraemia' named entity 'protein' named entity 'RNA' named entity 'positively selected' named entity 'B-cell' named entity 'NGS' named entity 'protein' named entity 'cell culture' named entity 'Cys' named entity 'HCV' named entity 'Lys' named entity 'sialoadhesin' named entity 'Trizol' named entity 'cysteine protease' named entity 'neutralizing antibodies' named entity 'neutralizing antibodies' named entity 'Hepatitis C virus' named entity 'viraemia' named entity 'inoculum'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software