About: Clinical and laboratory characteristics of viral lower respiratory tract infections in preschool children

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical and laboratory characteristics of viral lower respiratory tract infections in preschool children
Creator	Duh, Darja Berce, Vojko Berce, Asist Duh, D Homšak, Matjaž Homšak, · Unuk, S Unuk, Sibila Vičič, Maja Vičič, ·
Source	Medline; PMC
abstract	BACKGROUND: Viral lower respiratory tract infections are the leading cause of hospitalizations in preschool children. Clinical pictures of different viral causes are not well characterized. The aim of this study was to establish the differences in clinical and laboratory characteristics between the different viral causes of lower respiratory tract infections in preschool children. METHODS: We included 278 preschool children hospitalized because of lower respiratory tract infection. White blood cell count and C-reactive protein values were determined and chest X-ray was performed in most patients. Polymerase chain reaction assay was used for the detection of viral pathogens from nasopharyngeal swab. RESULTS: Pneumonia was present in 71.4 % of all coronavirus infections, 35.1 % of all respiratory syncytial virus infections, and 13.0 % of all rhinovirus infections. Coronavirus (p = 0.03) and respiratory syncytial virus (p < 0.01) were retrospectively shown to be associated with the presence of pneumonia and rhinovirus (p < 0.01) with the absence of pneumonia. Wheezing was present in 81.5 % of all rhinovirus infections and in only 33.3 % of all adenovirus infections. Rhinovirus (p < 0.01) was associated with the presence of wheezing and adenovirus (p = 0.05) with the absence of wheezing. In adenovirus infections mean C-reactive protein value was 72.4 mg/L and white blood cell count 19.000/µl, both significantly higher than in other viruses (p < 0.01). CONCLUSIONS: Clinical and laboratory characteristics of viral lower respiratory tract infections significantly differ. With the advance of viral detection methods and increase of knowledge it becomes possible to characterize different respiratory viral infections and to improve the differential diagnosis.
has issue date	2015-09-15(xsd:dateTime)
bibo:doi	10.1007/s00508-015-0843-2
bibo:pmid	26373742
has license	no-cc
sha1sum (hex)	d24b9ee5f6da8aad4daaa035c86598c1f29c19d5
schema:url	https://doi.org/10.1007/s00508-015-0843-2
resource representing a document's title	Clinical and laboratory characteristics of viral lower respiratory tract infections in preschool children
has PubMed Central identifier	PMC7087898
has PubMed identifier	26373742
schema:publication	Wien Klin Wochenschr
resource representing a document's body	covid:d24b9ee5f6da8aad4daaa035c86598c1f29c19d5#body_text
is schema:about of	named entity 'LABORATORY' named entity 'CHARACTERISTICS' named entity 'CLINICAL' named entity 'VIRAL LOWER RESPIRATORY TRACT INFECTIONS' named entity 'PRESCHOOL CHILDREN' named entity 'CLINICAL' named entity 'LABORATORY' named entity 'PRESCHOOL CHILDREN' named entity 'VIRAL LOWER RESPIRATORY TRACT INFECTIONS' named entity 'CHARACTERISTICS' covid:arg/d24b9ee5f6da8aad4daaa035c86598c1f29c19d5 named entity 'respiratory tract infections' named entity 'laboratory' named entity 'preschool' named entity 'lower respiratory tract infections' named entity 'preschool' named entity 'preschool' named entity 'lower respiratory tract infections' named entity 'Clinical' named entity 'preschool' named entity 'respiratory tract infections' named entity 'viral' nodeID://b56468930 nodeID://b56471310 nodeID://b56510646 nodeID://b57737694 nodeID://b57764006 nodeID://b57764530 nodeID://b57912722
is wasQuotedFrom of	covid:arg/d24b9ee5f6da8aad4daaa035c86598c1f29c19d5/0 covid:arg/d24b9ee5f6da8aad4daaa035c86598c1f29c19d5/1 covid:arg/d24b9ee5f6da8aad4daaa035c86598c1f29c19d5/2 covid:arg/d24b9ee5f6da8aad4daaa035c86598c1f29c19d5/3 covid:arg/d24b9ee5f6da8aad4daaa035c86598c1f29c19d5/4
is part of of	BACKGROUND: Viral lower respiratory tract infections are the leading cause of hospitalizations in preschool children. Clinical pictures of different viral causes are not well characterized. The aim of this study was to establish the differences in clinical and laboratory characteristics between the different viral causes of lower respiratory tract infections in preschool children. METHODS: We included 278 preschool children hospitalized because of lower respiratory tract infection. White blood cell count and C-reactive protein values were determined and chest X-ray was performed in most patients. Polymerase chain reaction assay was used for the detection of viral pathogens from nasopharyngeal swab. RESULTS: Pneumonia was present in 71.4 % of all coronavirus infections, 35.1 % of all respiratory syncytial virus infections, and 13.0 % of all rhinovirus infections. Coronavirus (p = 0.03) and respiratory syncytial virus (p < 0.01) were retrospectively shown to be associated with the presence of pneumonia and rhinovirus (p < 0.01) with the absence of pneumonia. Wheezing was present in 81.5 % of all rhinovirus infections and in only 33.3 % of all adenovirus infections. Rhinovirus (p < 0.01) was associated with the presence of wheezing and adenovirus (p = 0.05) with the absence of wheezing. In adenovirus infections mean C-reactive protein value was 72.4 mg/L and white blood cell count 19.000/µl, both significantly higher than in other viruses (p < 0.01). CONCLUSIONS: Clinical and laboratory characteristics of viral lower respiratory tract infections significantly differ. With the advance of viral detection methods and increase of knowledge it becomes possible to characterize different respiratory viral infections and to improve the differential diagnosis. covid:d24b9ee5f6da8aad4daaa035c86598c1f29c19d5#body_text Clinical and laboratory characteristics of viral lower respiratory tract infections in preschool children

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