About: Mouse hepatitis virus (MHV-4, JHM) blocks γ-interferon-induced major histocompatibility complex class II antigen expression on murine cerebral endothelial cells

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About: Mouse hepatitis virus (MHV-4, JHM) blocks γ-interferon-induced major histocompatibility complex class II antigen expression on murine cerebral endothelial cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mouse hepatitis virus (MHV-4, JHM) blocks γ-interferon-induced major histocompatibility complex class II antigen expression on murine cerebral endothelial cells
Creator	Joseph, Jeymohan Knobler, Robert Lublin, Fred Hart, M
Source	Elsevier; Medline; PMC
abstract	Abstract The regulation of γ-interferon-induced major histocompatibility complex (MHC) class II antigen expression on mouse cerebral endothelial cells by the neurotropic mouse hepatitis virus (MHV-4, JHM) was studied in vitro. The results presented demonstrate that MHV-4 can selectively block γ-interferon-induced class II antigen expression on cerebral endothelial cells. The blocking effect of class II expression occurs in a strain-dependent manner, and is limited to virus-susceptible mouse strains. Virus replication is not required to obtain the blocking effect since UV-inactivated MHV-4 produces the same result. MHV-4 blocking of γ-interferon-induced class II antigen expression is observed at both the cell surface (flow cytometry) and transcriptional level (Norhtern analysis).
has issue date	1991-09-30(xsd:dateTime)
bibo:doi	10.1016/0165-5728(91)90105-g
bibo:pmid	1651958
has license	els-covid
sha1sum (hex)	d21ed233f68e771ed354751e328493b9e474e94b
schema:url	https://doi.org/10.1016/0165-5728%2891%2990105-g
resource representing a document's title	Mouse hepatitis virus (MHV-4, JHM) blocks γ-interferon-induced major histocompatibility complex class II antigen expression on murine cerebral endothelial cells
has PubMed Central identifier	PMC7119494
has PubMed identifier	1651958
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:d21ed233f68e771ed354751e328493b9e474e94b#body_text
is schema:about of	covid:arg/d21ed233f68e771ed354751e328493b9e474e94b named entity 'antigen presentation' named entity 'receptor' named entity 'interferon' named entity 'virus' named entity 'endothelial cells' named entity 'class II' named entity 'class II' named entity 'Virus replication' named entity 'transcriptional' named entity 'interferon' named entity 'Northern analysis' named entity 'class II' named entity 'interferon' named entity 'antigen' named entity 'interferon' named entity 'positive polarity' named entity 'MHC class II' named entity 'cytolytic' named entity 'virus infection' named entity 'endothelial cells' named entity 'interferon' named entity 'U.S.A.' named entity 'RNA' named entity 'Hoffman Estates' named entity 'interferon' named entity 'pH 8' named entity 'virus' named entity 'Amersham' named entity 'Endothelial cells' named entity 'class II' named entity 'MOI' named entity 'clone' named entity 'haplotype' named entity 'class II' named entity 'immunopathologic' named entity 'class II' named entity 'virus replication' named entity 'Fluorescein' named entity 'interferon' named entity 'class II' named entity 'U.S.A.' named entity 'recombinant' named entity 'ethanol' named entity 'plaque assays' named entity 'dead cells' named entity 'sodium phosphate' named entity 'formal proof' named entity 'class II' named entity 'endothelial cells' named entity 'hepatitis B virus' named entity 'interferon' named entity 'IgG2a' named entity 'coronavirus' named entity 'endothelial cells' named entity 'electrophoresis' named entity 'dextran' named entity 'conjugated' named entity 'interferon' named entity 'interferon' named entity 'cyclic AMP' named entity 'ethidium bromide' named entity 'interferon' named entity 'class II' named entity 'titer' named entity 'Capillaries' named entity 'interleukin-1' named entity 'cytokine' named entity 'Percoll' named entity 'class II' named entity 'agarose' named entity 'ECGF' named entity 'mice' named entity 'virus' named entity 'haplotype' named entity 'U.S.A.' named entity 'host immunity' named entity 'fibroblasts'

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