About: Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis

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About: Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis
Creator	Døllner, Henrik Krokstad, Sidsel Moe, Nina Espevik, Terje Loevenich, Simon Malmo, Jostein Ryan, Liv Anthonsen, Marit Johnsen, Ingvild Nordbø, Svein
source	Medline; PMC
abstract	Human metapneumovirus (hMPV) causes severe airway infection in children that may be caused by an unfavorable immune response. The nature of the innate immune response to hMPV in naturally occurring infections in children is largely undescribed, and it is unknown if inflammasome activation is implicated in disease pathogenesis. We examined nasopharynx aspirates and blood samples from hMPV-infected children without detectable co-infections. The expression of inflammatory and antiviral genes were measured in nasal airway secretions by relative mRNA quantification while blood plasma proteins were determined by a multiplex immunoassay. Several genes were significantly up-regulated at mRNA and protein level in the hMPV infected children. Most apparent was the expression of the chemokine IP-10, the pro-inflammatory cytokine IL-18 in addition to the interferon inducible gene ISG54. Interestingly, children experiencing more severe disease, as indicated by a severity index, had significantly more often up-regulation of the inflammasome-associated genes IL-1β and NLRP3. Overall, our data point to cytokines, particularly inflammasome-associated, that might be important in hMPV mediated lung disease and the antiviral response in children with severe infection. Our study is the first to demonstrate that inflammasome components are associated with increased illness severity in hMPV-infected children.
has issue date	2016-05-12(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0155484
bibo:pmid	27171557
has license	cc-by
sha1sum (hex)	d1fd684938b2d4358d1fde27a474bf71df02287b
schema:url	https://doi.org/10.1371/journal.pone.0155484
resource representing a document's title	Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis
has PubMed Central identifier	PMC4865088
has PubMed identifier	27171557
schema:publication	PLoS One
resource representing a document's body	covid:d1fd684938b2d4358d1fde27a474bf71df02287b#body_text
is schema:about of	named entity 'antiviral' named entity 'apparent' named entity 'expression' named entity 'genes' named entity 'nasal' named entity 'INFECTIONS' named entity 'EXAMINED' named entity 'INVOLVED' named entity 'ASSOCIATED' named entity 'SEVERE' named entity 'DISEASE' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'CHILDREN' named entity 'LARGELY' named entity 'RELATIVE' named entity 'IMMUNE RESPONSE' named entity 'SECRETIONS' covid:arg/d1fd684938b2d4358d1fde27a474bf71df02287b named entity 'PLASMA PROTEINS' named entity 'INDUCIBLE' named entity 'INTERFERON ' named entity 'INFECTION' named entity 'ASSOCIATED WITH' named entity 'CYTOKINE ' named entity 'INFLAMMATORY' named entity 'NATURALLY OCCURRING' named entity 'IL-18' named entity 'GENES' named entity 'INFECTED' named entity 'PATHOGENESIS' named entity 'PRO-INFLAMMATORY CYTOKINE' named entity 'ANTIVIRAL RESPONSE' named entity 'UP-REGULATION' named entity 'DETERMINED BY' named entity 'ISG54' named entity 'GENES' named entity 'INDEX' named entity 'IDENTIFICATION' named entity 'CHILDREN' named entity 'ANTIVIRAL RESPONSE' named entity 'CYTOKINE ' named entity 'UP-REGULATED' named entity 'INFECTED' named entity 'AIRWAY' named entity '10%' named entity 'LUNG DISEASE' named entity 'INFLAMMASOME ACTIVATION' named entity 'CYTOKINES' named entity 'IP-10' named entity 'DATA POINT' named entity 'DETECTABLE' named entity 'EXPRESSION' named entity 'IMPORTANT' named entity 'ILLNESS SEVERITY' named entity 'MEDIATED' named entity 'IMMUNOASSAY' named entity 'NASOPHARYNX' named entity 'NLRP3' named entity 'ADDITION' named entity 'STUDY' named entity 'INNATE IMMUNE RESPONSE' named entity 'MEASURED' named entity 'PATHOGENESIS' named entity 'MULTIPLEX' named entity 'OVERALL' named entity 'APPARENT' named entity 'INFLAMMASOME' named entity 'MRNA' named entity 'OUR' named entity 'NATURE' named entity 'CHEMOKINE' named entity 'RESPONSE TO'

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