About: A Novel Psittacine Adenovirus Identified During an Outbreak of Avian Chlamydiosis and Human Psittacosis: Zoonosis Associated with Virus-Bacterium Coinfection in Birds

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About: A Novel Psittacine Adenovirus Identified During an Outbreak of Avian Chlamydiosis and Human Psittacosis: Zoonosis Associated with Virus-Bacterium Coinfection in Birds Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Novel Psittacine Adenovirus Identified During an Outbreak of Avian Chlamydiosis and Human Psittacosis: Zoonosis Associated with Virus-Bacterium Coinfection in Birds
Creator	Sridhar, Siddharth Tse, Herman Yuen, Kwok-Yung Chan, Wan-Mui Chan, Kwok-Hung Vinetz, Joseph Chan, Jasper Cheng, Vincent Choi, Garnet Lau, Susanna Lo, Janice To, Kelvin Woo, Patrick Zhang, Anna Chan, Andy Hoy, Hui Ming, Hui Wong, Sally Yu, Carol Yu, Richard
Source	Medline; PMC
abstract	Chlamydophila psittaci is found worldwide, but is particularly common among psittacine birds in tropical and subtropical regions. While investigating a human psittacosis outbreak that was associated with avian chlamydiosis in Hong Kong, we identified a novel adenovirus in epidemiologically linked Mealy Parrots, which was not present in healthy birds unrelated to the outbreak or in other animals. The novel adenovirus (tentatively named Psittacine adenovirus HKU1) was most closely related to Duck adenovirus A in the Atadenovirus genus. Sequencing showed that the Psittacine adenovirus HKU1 genome consists of 31,735 nucleotides. Comparative genome analysis showed that the Psittacine adenovirus HKU1 genome contains 23 open reading frames (ORFs) with sequence similarity to known adenoviral genes, and six additional ORFs at the 3′ end of the genome. Similar to Duck adenovirus A, the novel adenovirus lacks LH1, LH2 and LH3, which distinguishes it from other viruses in the Atadenovirus genus. Notably, fiber-2 protein, which is present in Aviadenovirus but not Atadenovirus, is also present in Psittacine adenovirus HKU1. Psittacine adenovirus HKU1 had pairwise amino acid sequence identities of 50.3–54.0% for the DNA polymerase, 64.6–70.7% for the penton protein, and 66.1–74.0% for the hexon protein with other Atadenovirus. The C. psittaci bacterial load was positively correlated with adenovirus viral load in the lung. Immunostaining for fiber protein expression was positive in lung and liver tissue cells of affected parrots, confirming active viral replication. No other viruses were found. This is the first documentation of an adenovirus-C. psittaci co-infection in an avian species that was associated with a human outbreak of psittacosis. Viral-bacterial co-infection often increases disease severity in both humans and animals. The role of viral-bacterial co-infection in animal-to-human transmission of infectious agents has not received sufficient attention and should be emphasized in the investigation of disease outbreaks in human and animals.
has issue date	2014-12-04(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0003318
bibo:pmid	25474263
has license	cc-by
sha1sum (hex)	d1fc5729ff932800c93dbe279b36ea3c53375708
schema:url	https://doi.org/10.1371/journal.pntd.0003318
resource representing a document's title	A Novel Psittacine Adenovirus Identified During an Outbreak of Avian Chlamydiosis and Human Psittacosis: Zoonosis Associated with Virus-Bacterium Coinfection in Birds
has PubMed Central identifier	PMC4256287
has PubMed identifier	25474263
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:d1fc5729ff932800c93dbe279b36ea3c53375708#body_text
is schema:about of	named entity 'ASSOCIATED WITH' named entity 'NOVEL' named entity 'C. psittaci' named entity 'protein' named entity 'polymerase' named entity 'disease' named entity 'During' named entity 'epidemiologically' named entity 'birds' named entity 'nucleotides' named entity 'viruses' named entity 'Adenovirus' named entity 'Outbreak' named entity 'HEALTHY' named entity 'ZHANG' named entity 'BACTERIAL LOAD' named entity 'HUMANS' named entity 'IDENTITIES' named entity 'SEQUENCE SIMILARITY' named entity 'PSITTACOSIS' named entity 'BACTERIUM' named entity 'CHLAMYDIOSIS' named entity 'TROPICAL' named entity 'POSITIVELY CORRELATED' named entity 'LIVER TISSUE' named entity 'DISEASE OUTBREAKS' named entity 'ORFS' named entity 'LH2' named entity 'AMINO ACID SEQUENCE' named entity 'COMMON' named entity 'SPECIES' named entity 'HEXON PROTEIN' named entity 'AVIADENOVIRUS' named entity 'LACKS' named entity 'RECEIVED' named entity 'PROTEIN EXPRESSION' named entity 'VIRAL LOAD' named entity 'SIMILAR' named entity 'ADENOVIRUS' named entity 'PSITTACOSIS' named entity 'HUMAN' named entity 'ANIMALS' named entity 'KNOWN' named entity 'CHLAMYDIOSIS' named entity 'IDENTIFIED' named entity 'COINFECTION' named entity 'AVIAN' named entity 'BIRDS' named entity 'VIRUS' named entity 'ZOONOSIS' named entity 'DISEASE SEVERITY' named entity 'BIRDS' named entity 'INVESTIGATING' named entity 'LH3' named entity 'VIRUSES' named entity 'GENOME ANALYSIS' named entity 'BACTERIAL' named entity 'OTHER ANIMALS' named entity 'GENES' named entity 'PENTON PROTEIN' named entity 'VIRAL REPLICATION' named entity 'ZOONOSIS'

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