About: Design of Potential RNAi (miRNA and siRNA) Molecules for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Gene Silencing by Computational Method

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About: Design of Potential RNAi (miRNA and siRNA) Molecules for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Gene Silencing by Computational Method Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Design of Potential RNAi (miRNA and siRNA) Molecules for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Gene Silencing by Computational Method
Creator	Sharmin, Tahmina Hasan, Md Hossain, Mehjabeen Nur, Suza Al Amin, Mohammad
Source	Medline; PMC
abstract	The Middle East respiratory syndrome coronavirus (MERS-CoV) is a virus that manifests itself in viral infection with fever, cough, shortness of breath, renal failure and severe acute pneumonia, which often result in a fatal outcome. MERS-CoV has been shown to spread between people who are in close contact. Transmission from infected patients to healthcare personnel has also been observed and is irredeemable with present technology. Genetic studies on MERS-CoV have shown that ORF1ab encodes replicase polyproteins and play a foremost role in viral infection. Therefore, ORF1ab replicase polyprotein may be used as a suitable target for disease control. Viral activity can be controlled by RNA interference (RNAi) technology, a leading method for post transcriptional gene silencing in a sequence-specific manner. However, there is a genetic inconsistency in different viral isolates; it is a great challenge to design potential RNAi (miRNA and siRNA) molecules which can silence the respective target genes rather than any other viral gene simultaneously. In the current study, four effective miRNA and five siRNA molecules for silencing of nine different strains of MERS-CoV were rationally designed and corroborated using computational methods, which might lead to knockdown the activity of virus. siRNA and miRNA molecules were predicted against ORF1ab gene of different strains of MERS-CoV as effective candidate using computational methods. Thus, this method may provide an insight for the chemical synthesis of antiviral RNA molecule for the treatment of MERS-CoV, at genomic level.
has issue date	2015-07-30(xsd:dateTime)
bibo:doi	10.1007/s12539-015-0266-9
bibo:pmid	26223545
has license	no-cc
sha1sum (hex)	d1b2d508a135d8bb0b63c36af9881c8f467dfb18
schema:url	https://doi.org/10.1007/s12539-015-0266-9
resource representing a document's title	Design of Potential RNAi (miRNA and siRNA) Molecules for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Gene Silencing by Computational Method
has PubMed Central identifier	PMC7090891
has PubMed identifier	26223545
schema:publication	Interdiscip Sci
resource representing a document's body	covid:d1b2d508a135d8bb0b63c36af9881c8f467dfb18#body_text
is schema:about of	named entity 'effective' named entity 'manner' named entity 'RNA' named entity 'genomic' named entity 'MERS-CoV' named entity 'Gene Silencing' named entity 'Design' named entity 'DESIGN' named entity 'GREAT' named entity 'VIRAL ACTIVITY' named entity 'TARGET' named entity 'REPLICASE' named entity 'USING' named entity 'INFECTED' named entity 'CONTROLLED BY' named entity 'PERSONNEL' named entity 'CHALLENGE' named entity 'VIRUS' named entity 'STUDY' named entity 'USED' named entity 'FATAL OUTCOME' named entity 'POLYPROTEINS' named entity 'MIRNA' named entity 'SEVERE' named entity 'PATIENTS' named entity 'ACTIVITY' named entity 'DIFFERENT' named entity 'SIMULTANEOUSLY' named entity 'CURRENT' named entity 'SIRNA' named entity 'POLYPROTEIN' named entity 'EFFECTIVE' named entity 'ISOLATES' named entity 'SPECIFIC' named entity 'ACUTE PNEUMONIA' named entity 'VIRAL INFECTION' named entity 'RESULT' named entity 'RNA INTERFERENCE' named entity 'SPREAD' named entity 'GENETIC' named entity 'STUDIES' named entity 'DISEASE CONTROL' named entity 'RATHER' named entity 'GENOMIC' named entity 'SUITABLE' named entity 'GENE SILENCING' named entity 'PLAY' named entity 'POTENTIAL' named entity 'RNAI' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'COMPUTATIONAL METHOD' named entity 'TREATMENT' named entity 'PROVIDE' named entity 'POTENTIAL' named entity 'SEQUENCE' named entity 'DESIGN' named entity 'PRESENT' named entity 'RENAL FAILURE' named entity 'PEOPLE' named entity 'MAY BE' named entity 'SIRNA' named entity 'MOLECULES' named entity 'GENE' named entity 'ORF1AB' named entity 'RNA MOLECULE' named entity 'HAVE' named entity 'FEVER' named entity 'STRAINS' named entity 'COUGH' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'SILENCE' named entity 'LEADING' named entity 'IS A' named entity 'RNAI' named entity 'TRANSMISSION' named entity 'METHODS' named entity 'OBSERVED'

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