About: Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models
Creator	Sato, Y Iwata-Yoshikawa, N Naeem, A Nakajima, N Open Access Citation: Kotani, O Suzuki, T
topic	covid:d18e10321c54248f5fdfdac2501f5368ac8052c7#this
Source	PMC
abstract	OBJECTIVE: Saffold virus (SAFV), a picornavirus, is occasionally detected in children with acute flaccid paralysis, meningitis, and cerebellitis; however, the neuropathogenicity of SAFV remains undetermined. METHODS: The virulence of two clinical isolates of SAFV type 3 (SAFV-3) obtained from a patient with aseptic meningitis (AM strain) and acute upper respiratory inflammation (UR strain) was analyzed in neonatal and young mice utilizing virological, pathological, and immunological methods. RESULTS: The polyproteins of the strains differed in eight amino acids. Both clinical isolates were infective, exhibited neurotropism, and were mildly neurovirulent in neonatal ddY mice. Both strains pathologically infected neural progenitor cells and glial cells, but not large neurons, with the UR strain also infecting epithelial cells. UR infection resulted in longer inflammation in the brain and spinal cord because of demyelination, while the AM strain showed more infectivity in the cerebellum in neonatal ddY mice. Additionally, young BALB/c mice seroconverted following mucosal inoculation with the UR, but not the AM, strain. CONCLUSIONS: Both SAFV-3 isolates had neurotropism and mild neurovirulence but showed different cell tropisms in both neonatal and young mouse models. This animal model has the potential to recapitulate the potential neuropathogenicity of SAFV-3.
has issue date	2016-02-01(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0148184
bibo:pmid	26828718
has license	cc-by
sha1sum (hex)	d18e10321c54248f5fdfdac2501f5368ac8052c7
schema:url	https://doi.org/10.1371/journal.pone.0148184
resource representing a document's title	Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models
has PubMed Central identifier	PMC4734772
has PubMed identifier	26828718
schema:publication	PLoS One
resource representing a document's body	covid:d18e10321c54248f5fdfdac2501f5368ac8052c7#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/d18e10321c54248f5fdfdac2501f5368ac8052c7
is schema:about of	named entity 'UNDETERMINED' named entity 'CEREBELLITIS' named entity 'TYPE 3' named entity 'SAFFOLD VIRUS' named entity 'PICORNAVIRUS' named entity 'ISOLATES' named entity 'ACUTE FLACCID PARALYSIS' named entity 'CHILDREN' named entity 'SAFFOLD VIRUS' named entity 'DETECTED' named entity 'OCCASIONALLY' named entity 'VIRUS TYPE' named entity 'MENINGITIS' named entity 'MOUSE MODELS' covid:arg/d18e10321c54248f5fdfdac2501f5368ac8052c7 named entity 'virus' named entity 'picornavirus' named entity 'cerebellum' named entity 'Animal studies' named entity 'aseptic meningitis' named entity 'viremia' named entity 'one-way analysis of variance' named entity 'rodents' named entity 'cerebral cortex' named entity 'alkaline phosphatase' named entity 'kidney' named entity 'murine' named entity 'blindness' named entity 'cardiovirus' named entity 'Taq polymerase' named entity 'Goat' named entity 'brain stem' named entity 'aseptic meningitis' named entity 'nuclei' named entity 'MAP-2' named entity 'PCR' named entity 'neuroepithelial cells' named entity 'neurological disorders' named entity 'capsid protein' named entity 'CSF' named entity 'neuropathology' named entity 'intraperitoneal' named entity 'housekeeping gene' named entity 'Japan' named entity 'aseptic meningitis' named entity 'cerebrum' named entity 'RNA' named entity 'beta-actin' named entity 'aseptic meningitis' named entity 'feces' named entity 'H&E' named entity 'GLAST' named entity 'Taqman' named entity 'natural host' named entity 'perivascular' named entity 'Life Technologies Corporation' named entity 'infection' named entity 'genome' named entity 'CNS' named entity 'virus' named entity 'aseptic meningitis' named entity 'encephalomyelitis' named entity 'reverse transcriptase' named entity 'Molecular Probes' named entity 'inoculation' named entity 'Picornaviridae' named entity 'formalin' named entity 'MAG' named entity 'medulla' named entity 'viral RNA' named entity 'cerebellum' named entity 'neutralizing antibodies' named entity 'oral cavity' named entity 'aseptic meningitis'

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