About: COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection

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About: COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection
Creator	Ippolito, Giuseppe Vairo, Francesco Zumla, Alimuddin Maeurer, Markus Agrati, Chiara Piacentini, Mauro Locatelli, Franco Kobinger, Gary Giombini, Emanuela Capobianchi, Maria Bartoli, Tommaso Messina, Francesco Lauria, Francesco Al Moghazi, Samir
Source	Medline; PMC
abstract	BACKGROUND: Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatment modalities and to develop effective prevention strategies. Transcriptomic and proteomic data on the host response against SARS-CoV-2 still have anecdotic character; currently available data from other coronavirus infections are therefore a key source of information. METHODS: We investigated selected molecular aspects of three human coronavirus (HCoV) infections, namely SARS-CoV, MERS-CoV and HCoV-229E, through a network based-approach. A functional analysis of HCoV–host interactome was carried out in order to provide a theoretic host–pathogen interaction model for HCoV infections and in order to translate the results in prediction for SARS-CoV-2 pathogenesis. The 3D model of S-glycoprotein of SARS-CoV-2 was compared to the structure of the corresponding SARS-CoV, HCoV-229E and MERS-CoV S-glycoprotein. SARS-CoV, MERS-CoV, HCoV-229E and the host interactome were inferred through published protein–protein interactions (PPI) as well as gene co-expression, triggered by HCoV S-glycoprotein in host cells. RESULTS: Although the amino acid sequences of the S-glycoprotein were found to be different between the various HCoV, the structures showed high similarity, but the best 3D structural overlap shared by SARS-CoV and SARS-CoV-2, consistent with the shared ACE2 predicted receptor. The host interactome, linked to the S-glycoprotein of SARS-CoV and MERS-CoV, mainly highlighted innate immunity pathway components, such as Toll Like receptors, cytokines and chemokines. CONCLUSIONS: In this paper, we developed a network-based model with the aim to define molecular aspects of pathogenic phenotypes in HCoV infections. The resulting pattern may facilitate the process of structure-guided pharmaceutical and diagnostic research with the prospect to identify potential new biological targets.
has issue date	2020-06-10(xsd:dateTime)
bibo:doi	10.1186/s12967-020-02405-w
bibo:pmid	32522207
has license	cc-by
sha1sum (hex)	d14db0925754fcc56e72fb3fea3835246ff28c67
schema:url	https://doi.org/10.1186/s12967-020-02405-w
resource representing a document's title	COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection
has PubMed Central identifier	PMC7286221
has PubMed identifier	32522207
schema:publication	J Transl Med
resource representing a document's body	covid:d14db0925754fcc56e72fb3fea3835246ff28c67#body_text
is schema:about of	named entity 'strategies' named entity 'pathophysiology' named entity 'infections' named entity 'infection' named entity 'SARS-CoV-2' named entity 'TREATMENT' named entity 'PROTEOMIC' named entity 'SARS-COV-2 INFECTION' named entity 'ASSOCIATED WITH' named entity 'interactome' named entity 'COVID-19' named entity 'Epidemiological' named entity 'coronavirus infections' named entity 'cytokines' named entity 'SARS-CoV' named entity 'SARS-CoV-2' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'pathogenesis' named entity 'chemokine' named entity 'receptor' named entity 'SARS-CoV' named entity 'inflammatory' named entity 'CXCL2' named entity 'virus' named entity 'MERS-CoV' named entity 'biological processes' named entity 'ACE2' named entity 'gene' named entity 'SARS-CoV' named entity 'chemokine' named entity 'SARS-CoV' named entity 'viral entry' named entity 'MERS-CoV' named entity 'protein' named entity 'glycoprotein' named entity 'gene' named entity 'TGF-β' named entity 'cellular proliferation' named entity 'SARS-CoV' named entity 'PPI' named entity 'ubiquitin' named entity 'lungs' named entity 'FDR' named entity 'gene expression' named entity 'DNA repair' named entity 'Protein' named entity 'MAPK pathway' named entity 'HCoV-229E' named entity 'respiratory tract infections' named entity 'cytokines' named entity 'Reactome' named entity 'HCoV-229E' named entity 'p38 MAPK' named entity 'IP-10' named entity 'FDR' named entity 'gene' named entity 'SARS-CoV' named entity 'statistical significance' named entity 'infection' named entity '229E' named entity 'FDR' named entity 'CCL11' named entity 'MERS-CoV' named entity 'CCR4' named entity 'proteome' named entity 'three-dimensional structure' named entity 'chemokines'

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