About: Multiplex Cytokine Profiling of Initial Therapeutic Response in Patients with Chronic Hepatitis C Virus Infection

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About: Multiplex Cytokine Profiling of Initial Therapeutic Response in Patients with Chronic Hepatitis C Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multiplex Cytokine Profiling of Initial Therapeutic Response in Patients with Chronic Hepatitis C Virus Infection
Creator	Alex, Philip Bader, Teddy Centola, Michael Dozmorov, Igor Gonzales, Liberty Gurakar, Ahmet Medi, Oklahoma Naylor, Mark Nazhi, Nguyen, Thuan Nour, Bakr Sebastian, Anthony Wallis, Gemma Wright, Harlan
Source	PMC
abstract	Currently available prognostic tools are inadequate to discern the molecular basis of the heterogenic response in hepatitis C virus (HCV)-infected patients treated with the current standard of therapy. The expression and biological function of immune mediators have been shown to be critical in all phases of the immune response to HCV infection and likely therefore influence host response. Herein, a biometric multiplex serum cytokine assay was utilized to characterize the immunomodulatory effects of host response in 10 HCV patients. Serum levels of 17 cytokines were compared before and after 1 month of treatment and against controls. Overall serum cytokine levels were significantly higher in patients (P < 0.05) than controls. Additionally, viral titers decreased in all patients after 1 month of therapy, as did overall serum cytokine levels in the cohort (P < 0.05). To assess relationships between changes in cytokine levels and changes in viral titer, the cohort was divided into three statistically distinct subgroups based on changes in viral titers. Specific sets of cytokines decreased in each group: decreases in CCL4, interleukin (IL)-2, CXCL8, and IL-1β correlated with the greatest drops in viral titer, decreases in IL-5, granulocyte colony stimulating factor (G-CSF), and CCL4 correlated with moderate drops in viral titer, and only CCL2 correlated with the lowest drops in viral titer. Interestingly, decreases in CCL4 levels correlated with decreases in viral titers in all patients. CCL4 controls leukocyte influx and thus propagates inflammation. In conclusion, these data raise the possibility that characteristic changes in host response modulate the therapeutic response, demonstrating the prognostic power of serum cytokine profiling in chronic HCV.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1007/s10620-005-2940-y
bibo:pmid	16187176
has license	no-cc
sha1sum (hex)	d147adaea164c2462d258b161300db6843a53a59
schema:url	https://doi.org/10.1007/s10620-005-2940-y
resource representing a document's title	Multiplex Cytokine Profiling of Initial Therapeutic Response in Patients with Chronic Hepatitis C Virus Infection
has PubMed Central identifier	PMC7087834
has PubMed identifier	16187176
schema:publication	Dig Dis Sci
resource representing a document's body	covid:d147adaea164c2462d258b161300db6843a53a59#body_text
is schema:about of	named entity 'CHRONIC HEPATITIS C VIRUS INFECTION' named entity 'levels' named entity 'immunomodulatory' named entity 'host response' named entity 'factor' named entity 'CCL4' named entity 'correlated' named entity 'IL-5' named entity 'titer' named entity 'cytokine' named entity 'hepatitis C virus' named entity 'data' named entity 'raise' named entity 'levels' named entity 'Infection' named entity 'Profiling' named entity 'LEUKOCYTE' named entity 'COHORT' named entity 'CCL2' named entity 'EXPRESSION' named entity 'POSSIBILITY' named entity 'CYTOKINES' named entity '28P' named entity 'DECREASED' named entity 'STATISTICALLY' named entity 'IL-5' named entity 'SERUM' named entity 'CONCLUSION' named entity 'RESPONSE' named entity 'EFFECTS' named entity 'LOWEST' named entity 'HEPATITIS C VIRUS' named entity 'MULTIPLEX' named entity 'HCV INFECTION' named entity '28G' named entity 'TOOLS' named entity 'THERAPY' named entity 'CXCL8' named entity 'TREATMENT' named entity 'DECREASES' named entity 'INITIAL' named entity 'THERAPEUTIC RESPONSE' named entity 'HCV' named entity 'IMMUNOMODULATORY' named entity 'PATIENTS' named entity 'MULTIPLEX' named entity 'CYTOKINE ' named entity 'IMMUNE RESPONSE' named entity 'CRITICAL' named entity 'MONTH' named entity 'BIOLOGICAL FUNCTION' named entity 'THERAPEUTIC RESPONSE' named entity '0.05' named entity 'HAVE' named entity 'GRANULOCYTE COLONY STIMULATING FACTOR' named entity 'SPECIFIC' named entity 'INTERLEUKIN ' named entity 'HOST RESPONSE' named entity 'CORRELATED' named entity 'BASED' named entity 'SUBGROUPS' named entity 'CHARACTERISTIC' named entity 'DID' named entity 'DROPS' named entity 'CURRENT' named entity 'INFLUENCE' named entity 'MODULATE' named entity 'VIRAL TITER'

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