About: New Diagnosis of G6PD Deficiency Presenting as Severe Rhabdomyolysis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	New Diagnosis of G6PD Deficiency Presenting as Severe Rhabdomyolysis
Creator	Angelini, Dana Eziokwu, Akaolisa
Source	Medline; PMC
abstract	A 24-year-old African-American man presented with malaise and low back pain and was found to have acute severe rhabdomyolysis followed by acute hemolysis. Glucose-6-phosphate dehydrogenase (G6PD) deficiency was suspected by the presence of blister cells on peripheral smear and was confirmed by a low enzyme activity assay. Our patient reported playing football, along with upper respiratory infection symptoms, prior to presentation. Extensive infectious and toxicology workup was negative; however, several inflammatory proteins were markedly elevated. We hypothesized the large inflammatory burden led to an increased reactive oxygen radical burden that overwhelmed muscle and erythrocyte reducing power. Severe rhabdomyolysis in G6PD deficiency is not a common presentation because skeletal muscles are more resistant to oxidative damage compared to red blood cells. Our case adds to the few existing reports of myolysis in the setting of G6PD deficiency.
has issue date	2018-03-28(xsd:dateTime)
bibo:doi	10.7759/cureus.2387
bibo:pmid	29850382
has license	cc-by
sha1sum (hex)	d130fc09f47711585fbeec45605bb516380eb5c5
schema:url	https://doi.org/10.7759/cureus.2387
resource representing a document's title	New Diagnosis of G6PD Deficiency Presenting as Severe Rhabdomyolysis
has PubMed Central identifier	PMC5973499
has PubMed identifier	29850382
schema:publication	Cureus
resource representing a document's body	covid:d130fc09f47711585fbeec45605bb516380eb5c5#body_text
is schema:about of	named entity 'suspected' named entity 'oxidative damage' named entity 'case' named entity 'elevated' named entity 'NEW DIAGNOSIS' named entity 'PRESENCE OF' named entity 'ERYTHROCYTE' named entity 'OXYGEN RADICAL' named entity 'RED BLOOD CELLS' named entity 'PERIPHERAL' named entity 'A COMMON' named entity 'MALAISE' named entity 'G6PD DEFICIENCY' named entity 'PROTEINS' named entity 'MAN' named entity 'SETTING' named entity 'RESISTANT TO' named entity 'REDUCING' named entity 'DEFICIENCY' named entity 'SUSPECTED' named entity 'CONFIRMED BY' named entity 'SEVERE' named entity 'MYOLYSIS' named entity 'BLISTER CELLS' named entity 'ACUTE' named entity 'GLUCOSE-6-PHOSPHATE DEHYDROGENASE' named entity 'LOW' named entity 'EXTENSIVE' named entity 'OXIDATIVE DAMAGE' named entity 'YEAR' named entity 'POWER' named entity 'PRESENTED' named entity 'ELEVATED' named entity 'HEMOLYSIS' named entity 'OUR' named entity 'INFECTIOUS' named entity 'MARKEDLY' named entity 'CASE' named entity 'SYMPTOMS' named entity 'AFRICAN-AMERICAN' named entity 'FOLLOWED BY' named entity 'UPPER RESPIRATORY INFECTION' named entity 'BURDEN' named entity 'ENZYME ACTIVITY ASSAY' named entity 'RHABDOMYOLYSIS' named entity 'SKELETAL MUSCLES' named entity 'SEVERE' named entity 'LOW BACK PAIN' named entity 'PATIENT REPORTED' named entity 'REACTIVE' named entity 'COMPARED' named entity 'MUSCLE' named entity 'TOXICOLOGY' named entity 'RHABDOMYOLYSIS' named entity 'OLD' named entity 'HAVE' named entity 'G6PD DEFICIENCY' named entity 'LED' named entity 'LARGE' named entity 'SMEAR' named entity 'PRESENTATION' named entity 'PLAYING' named entity 'FOOTBALL' named entity 'NEGATIVE' named entity 'INCREASED' named entity 'FOUND' named entity 'PRESENTING' named entity 'REPORTS' named entity 'INFLAMMATORY' named entity 'PRIOR TO' covid:arg/d130fc09f47711585fbeec45605bb516380eb5c5 named entity 'led' named entity 'erythrocyte' named entity 'presented' named entity 'burden' named entity 'Our' named entity 'inflammatory' named entity 'workup' named entity 'African-American' named entity 'G6PD'

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