About: Susceptibility of the Iranian population to severe acute respiratory syndrome coronavirus 2 infection based on variants of angiotensin I converting enzyme 2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Susceptibility of the Iranian population to severe acute respiratory syndrome coronavirus 2 infection based on variants of angiotensin I converting enzyme 2
Creator	Askari, Fatemeh Bagheri, Hanieh Ebrahimi, Mohsen Javid, Naeme Mohebbi, Alireza Yasaghi, Mohammad Zakeri, Mana
Source	PMC
abstract	Background: Variations in the viral receptor human angiotensin-converting enzyme 2 (ACE2) may specify the susceptibility of a certain population to severe acute respiratory syndrome coronavirus 2. Objective: Evaluation of the affinity of severe acute respiratory syndrome coronavirus 2 spike glycoprotein to the Iranian genetic variants of ACE2. Materials & methods: Single nucleotide polymorphisms of ACE2 among the Iranian population were collected from the Iranome database. Missense mutations in the N-terminal peptidase domain were selected for in silico analysis. Results: 17 missense single nucleotide polymorphisms were found at ACE2. Viral glycoprotein had the lowest affinity to ACE2 mutant V485L. Discussion: The V485L variant of ACE2 could be a natural resistance mutation among the Iranian population. In addition, variant S331F can increase slightly the susceptibility to infection with the virus.
has issue date	2020-08-17(xsd:dateTime)
bibo:doi	10.2217/fvl-2020-0160
has license	cc-by
sha1sum (hex)	d11f990d27d6a312f2adbf6cdeff544a475176f3
schema:url	https://doi.org/10.2217/fvl-2020-0160
resource representing a document's title	Susceptibility of the Iranian population to severe acute respiratory syndrome coronavirus 2 infection based on variants of angiotensin I converting enzyme 2
has PubMed Central identifier	PMC7430191
resource representing a document's body	covid:d11f990d27d6a312f2adbf6cdeff544a475176f3#body_text
is schema:about of	named entity 'VARIATIONS' named entity 'SPIKE GLYCOPROTEIN' named entity 'NATURAL' named entity 'SELECTED' named entity 'IRANIAN' named entity 'MATERIALS' named entity 'DISCUSSION' named entity 'HUMAN' named entity 'COLLECTED' named entity 'RESISTANCE' named entity 'EVALUATION' named entity 'VIRAL GLYCOPROTEIN' named entity 'VIRAL RECEPTOR' named entity 'MUTATION' named entity 'INCREASE' named entity 'database' named entity 'angiotensin' named entity 'infection' named entity 'virus' named entity 'Single nucleotide polymorphisms' named entity 'peptidase' named entity 'glycoprotein' named entity 'ACE2' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'ACE2' named entity 'ADDITION' named entity 'SINGLE NUCLEOTIDE POLYMORPHISMS' named entity 'CERTAIN' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2' named entity 'MISSENSE MUTATIONS' named entity 'natural resistance' named entity 'receptor' named entity 'Missense mutations' named entity 'COULD BE' named entity 'AFFINITY' named entity 'SUSCEPTIBILITY' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'DATABASE' named entity 'ACE2' named entity 'DOMAIN' named entity 'OBJECTIVE' named entity 'VIRUS' named entity 'MUTANT' named entity 'N-TERMINAL ' named entity 'RESULTS' named entity 'enzyme' named entity 'MISSENSE' named entity 'missense' named entity 'ACE2' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'mutation' named entity 'ACE2' named entity 'ACE2' covid:arg/d11f990d27d6a312f2adbf6cdeff544a475176f3 named entity 'single nucleotide polymorphisms' named entity 'METHODS' named entity 'PEPTIDASE' named entity 'POPULATION' named entity 'IN SILICO ANALYSIS' named entity 'Viral' named entity 'infection' named entity 'angiotensin-converting enzyme 2' named entity 'glycoprotein' named entity 'ACE2' named entity 'N-terminal' named entity 'genetic variants' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'LOWEST' named entity 'GENETIC' named entity 'SPECIFY' named entity 'SUSCEPTIBILITY TO INFECTION' named entity 'VARIANT' named entity 'SLIGHTLY' named entity 'FOUND' named entity 'SUSCEPTIBILITY' named entity 'BASED' named entity 'ANGIOTENSIN I CONVERTING ENZYME 2' named entity 'IRANIAN'

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