About: SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6

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About: SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6
Creator	Lin, Cheng-Wen Lin, Ying-Ju Wan, Lei Li, Shih-Wen Huang, Su-Hua Hsiao, Li-Hsin Jou, Yu-Jen Kung, Szu-Hao Wang, Ching-Ying
topic	covid:d117c8256785f2ff80a40fba878aa4f022d8310b#this
Source	Medline; PMC
abstract	Severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLPro) reportedly inhibits the production of type I interferons (IFNs) and pro-inflammatory cytokines in Toll-like receptor 3 (TLR3) and retinoic acid-inducible gene 1 (RIG-I) pathways. The study investigated the inhibitory effect and its antagonistic mechanism of SARS-CoV PLPro on TLR7-mediated cytokine production. TLR7 agonist (imiquimod (IMQ)) concentration-dependently induced activation of ISRE-, NF-κB- and AP-1-luciferase reporters, as well as the production of IFN-α, IFN-β, TNF-α, IL-6 and IL-8 in human promonocyte cells. However, SARS-CoV PLPro significantly inhibited IMQ-induced cytokine production through suppressing the activation of transcription factors IRF-3, NF-κB and AP-1. Western blot analysis with anti-Lys48 and anti-Lys63 ubiquitin antibodies indicated the SARS-CoV PLPro removed Lys63-linked ubiquitin chains of TRAF3 and TRAF6, but not Lys48-linked ubiquitin chains in un-treated and treated cells. The decrease in the activated state of TRAF3 and TRAF6 correlated with the inactivation of TBK1 in response to IMQ by PLPro. The results revealed that the antagonism of SARS-CoV PLPro on TLR7-mediated innate immunity was associated with the negative regulation of TRAF3/6-TBK1-IRF3/NF-κB/AP1 signals.
has issue date	2016-05-05(xsd:dateTime)
bibo:doi	10.3390/ijms17050678
bibo:pmid	27164085
has license	cc-by
sha1sum (hex)	d117c8256785f2ff80a40fba878aa4f022d8310b
schema:url	https://doi.org/10.3390/ijms17050678
resource representing a document's title	SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6
has PubMed Central identifier	PMC4881504
has PubMed identifier	27164085
schema:publication	Int J Mol Sci
resource representing a document's body	covid:d117c8256785f2ff80a40fba878aa4f022d8310b#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/d117c8256785f2ff80a40fba878aa4f022d8310b
is schema:about of	named entity 'IL-8' named entity 'innate' named entity 'chains' named entity 'cytokine' named entity 'Pathway' named entity 'TLR7' covid:arg/d117c8256785f2ff80a40fba878aa4f022d8310b named entity 'SARS-CoV' named entity 'AP-1' named entity 'IFN-β' named entity 'antibodies' named entity 'AP1' named entity 'mediated' named entity 'TLR7' named entity 'RIG-I' named entity 'NF-κB' named entity 'TRAF6' named entity 'TLR7' named entity 'inducible gene' named entity 'luciferase' named entity 'AP1' named entity 'TLR7' named entity 'TRAF3' named entity 'NF-κB' named entity 'TRAF6' named entity 'SARS' named entity 'TRAF3' named entity 'TRAF3' named entity 'phosphorylation' named entity 'statistical significance' named entity 'transfected' named entity 'TLR7' named entity 'SARS-CoV' named entity 'ubiquitination' named entity 'de-ubiquitination' named entity 'IRF-3' named entity 'MAVS' named entity 'SARS-CoV' named entity 'IRF3' named entity 'NF-κB' named entity 'NF-κB' named entity 'pro-inflammatory cytokines' named entity 'agonist' named entity 'TRAF3' named entity 'NF-κB' named entity 'c-Jun' named entity 'mRNA' named entity 'phosphor' named entity 'intracellular' named entity 'IFN-β' named entity 'TLR7' named entity 'TIR domain' named entity 'agonist' named entity 'p65' named entity 'Immunoprecipitation' named entity 'AP-1' named entity 'SARS-CoV' named entity 'β-actin' named entity 'vector' named entity 'SARS-CoV' named entity 'RNAs' named entity 'interferon' named entity 'p38 MAPK' named entity 'IRF3' named entity 'antiviral' named entity 'TLR7' named entity 'cell lysates' named entity 'TLR7' named entity 'cell lines' named entity 'p38 MAPK' named entity 'TNF-α'

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