About: Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

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About: Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
Creator	Clini, Enrico Fantini, Riccardo Cossarizza, Andrea Gibellini, Lara Bellinazzi, Caterina Borella, Rebecca Brugioni, Lucio Cicchetti, Luca De Biasi, Sara Facchinetti, Fabio Fidanza, Lucia Franceschi, Giacomo Girardis, Massimo Gozzi, Licia Guaraldi, Giovanni Iannone, Anna Lo Tartaro, Domenico Mattioli, Marco Menozzi, Marianna Meschiari, Marianna Milić, Jovana Mussini, Cristina Paolini, Annamaria Pietrangelo, Antonello Sarti, Mario Sita, Marco Tonelli, Roberto Trenti, Tommaso
Source	Medline; PMC
abstract	The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients’ T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1(+)CD57(+) exhausted T cells. Significant alterations exist also in several lineage-specifying transcription factors and chemokine receptors. Terminally differentiated T cells from patients proliferate less than those from healthy controls, whereas their mitochondria functionality is similar in CD4(+) T cells from both groups. Patients display significant increases of proinflammatory or anti-inflammatory cytokines, including T helper type-1 and type-2 cytokines, chemokines and galectins; their lymphocytes produce more tumor necrosis factor (TNF), interferon-γ, interleukin (IL)-2 and IL-17, with the last observation implying that blocking IL-17 could provide a novel therapeutic strategy for COVID-19.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1038/s41467-020-17292-4
bibo:pmid	32632085
has license	cc-by
sha1sum (hex)	d0dd47696b81ee03d955afaf081b4bb8b3b4e8cf
schema:url	https://doi.org/10.1038/s41467-020-17292-4
resource representing a document's title	Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
has PubMed Central identifier	PMC7338513
has PubMed identifier	32632085
schema:publication	Nat Commun
resource representing a document's body	covid:d0dd47696b81ee03d955afaf081b4bb8b3b4e8cf#body_text
is schema:about of	named entity 'mitochondria' named entity 'T helper' named entity 'transcription factors' named entity 'SARS-CoV-2' named entity 'TH17' named entity 'T cell' named entity 'COVID-19' named entity 'LESS THAN' covid:arg/d0dd47696b81ee03d955afaf081b4bb8b3b4e8cf named entity 'strategy' named entity 'patients' named entity 'lymphocytes' named entity 'Here' named entity 'patients' named entity 'therapeutic' named entity 'differentiated cells' named entity 'chemokine' named entity 'COVID-19' named entity 'Patients' named entity 'CD4 +' named entity 'anti-inflammatory' named entity 'IL-17' named entity 'interferon-γ' named entity 'pneumonia' named entity 'cytokines' named entity 'TNF' named entity 'cytokine' named entity 'IL-17' named entity 'differentiated' named entity 'CCL-2' named entity 'phenotype' named entity 'chemokine' named entity 'effector' named entity 'keratinocytes' named entity 'IL-2' named entity 'memory cells' named entity 'corona virus' named entity 'CD8 +' named entity 'IFN-γ' named entity 'CD107a' named entity 'dimensionality reduction' named entity 'Santa Clara, CA' named entity 'NIH' named entity 'HLA-DR' named entity 'PBMCs' named entity 'sore throat' named entity 'IL-17' named entity 'pregnant women' named entity 'phenotype' named entity 'regulatory T cells' named entity 'CD27' named entity 'CD4' named entity 'hypaque' named entity 'heat map'

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