About: Clinical Assessment and Improved Diagnosis of Bocavirus-induced Wheezing in Children, Finland

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About: Clinical Assessment and Improved Diagnosis of Bocavirus-induced Wheezing in Children, Finland Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical Assessment and Improved Diagnosis of Bocavirus-induced Wheezing in Children, Finland
Creator	Kemppainen, Kaisa Söderlund-Venermo, Maria Jartti, Tuomas Ruuskanen, Olli Hedman, Klaus Hedman, Lea Allander, Tobias Lahtinen, Anne Lehtinen, Pasi Hed-Man, L Hedman, K Hedman, L Kemppainen, K Lahtinen, A
source	PMC
abstract	Human bocavirus (HBoV) is a widespread respiratory virus. To improve diagnostic methods, we conducted immunoglobulin (Ig) G and IgM enzyme immunoassays with recombinant virus–like particles of HBoV as antigen. Acute-phase and follow-up serum samples from 258 wheezing children and single serum samples from 115 healthy adults in Finland were examined. Our assays had a sensitivity of 97% and a specificity of 99.5%. Of adults, 96% had immunity; none had an acute infection. Of 48 children with serologically diagnosed acute HBoV infections, 45 were viremic and 35 had virus in nasopharyngeal aspirates (NPAs). Of 39 HBoV NPA PCR–positive children co-infected with another virus, 64% had a serologically verified HBoV infection. HBoV caused illness of longer duration than rhinovirus and of equal severity to that of respiratory syncytial virus. Among children with bronchiolitis, >25% had acute HBoV infections. Accurate HBoV diagnosis requires serologic analysis or PCR of serum; PCR of NPAs alone is insufficient.
has issue date	2009-09-01(xsd:dateTime)
bibo:doi	10.3201/eid1509.090204
bibo:pmid	19788810
has license	no-cc
sha1sum (hex)	d0c33264c3dc13c6c5f3a3d83bdde246bdc82165
schema:url	https://doi.org/10.3201/eid1509.090204
resource representing a document's title	Clinical Assessment and Improved Diagnosis of Bocavirus-induced Wheezing in Children, Finland
has PubMed Central identifier	PMC2819894
has PubMed identifier	19788810
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:d0c33264c3dc13c6c5f3a3d83bdde246bdc82165#body_text
is schema:about of	named entity 'immunoglobulin' named entity 'Human bocavirus' named entity 'NPAs' named entity 'VERIFIED' named entity 'SEVERITY' named entity 'CAUSED' named entity '115' covid:arg/d0c33264c3dc13c6c5f3a3d83bdde246bdc82165 named entity 'CHILDREN' named entity 'FOLLOW-UP' named entity 'ADULTS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'SPECIFICITY' named entity 'OUR' named entity 'IMMUNOGLOBULIN' named entity 'RHINOVIRUS' named entity 'METHODS' named entity 'NPA' named entity 'WIDESPREAD' named entity 'VIRUS' named entity 'FINLAND' named entity 'INFECTION' named entity 'RECOMBINANT VIRUS' named entity 'ILLNESS' named entity 'SEROLOGIC' named entity 'INFECTIONS' named entity 'NASOPHARYNGEAL' named entity 'SERUM' named entity 'INFECTED' named entity 'ANTIGEN' named entity 'SAMPLES' named entity 'VIRUS-LIKE PARTICLES' named entity 'IGM' named entity 'PCR' named entity 'ENZYME IMMUNOASSAYS' named entity 'WHEEZING' named entity 'HEALTHY' named entity 'DIAGNOSIS' named entity 'ASPIRATES' named entity 'ACUTE' named entity '99.5' named entity 'EXAMINED' named entity 'IS A' named entity 'EQUAL' named entity 'INSUFFICIENT' named entity 'SENSITIVITY' named entity 'DIAGNOSED' named entity 'IMMUNITY' named entity 'SINGLE' named entity '258' named entity 'POSITIVE' named entity 'DURATION' named entity 'HUMAN BOCAVIRUS' named entity 'ACCURATE' named entity 'RESPIRATORY VIRUS' named entity 'DIAGNOSTIC' named entity 'ACUTE INFECTION' named entity 'ANALYSIS' named entity 'BRONCHIOLITIS' named entity 'respiratory' named entity 'virus' named entity 'Finland' named entity 'wheezing' named entity 'aspirates' named entity 'NPA' named entity 'recombinant' named entity 'co-infected' named entity 'HBoV'

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