About: Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration
Creator	Wang, Hua Ballmick, Asha Betancourt, Michel Cruz-Guilloty, Fernando Duffort, Stephanie Ewald, Eric Feuer, William Hong, Li Sene, Abdoulaye Tan, Yaohong Viteri, Eduardo Wen, Rong Saeed, Ali Apte, Rajendra Echegaray, Jose Hollyfield, Joe Huang, Deqiang Laird, James Perez, Victor Ramkhellawan, Ghansham Salomon, Robert
Source	PMC
abstract	Age-related macular degeneration (AMD) is a major cause of blindness in the developed world. Oxidative stress and inflammation are implicated in AMD, but precise mechanisms remain poorly defined. Carboxyethylpyrrole (CEP) is an AMD-associated lipid peroxidation product. We previously demonstrated that mice immunized with CEP-modified albumin developed AMD-like degenerative changes in the outer retina. Here, we examined the kinetics of lesion development in immunized mice and the presence of macrophages within the interphotoreceptor matrix (IPM), between the retinal pigment epithelium and photoreceptor outer segments. We observed a significant and time-dependent increase in the number of macrophages in immunized mice relative to young age-matched controls prior to overt pathology. These changes were more pronounced in BALB/c mice than in C57BL/6 mice. Importantly, IPM-infiltrating macrophages were polarized toward the M1 phenotype but only in immunized mice. Moreover, when Ccr2-deficient mice were immunized, macrophages were not present in the IPM and no retinal lesions were observed, suggesting a deleterious role for these cells in our model. This work provides mechanistic evidence linking immune responses against oxidative damage with the presence of proinflammatory macrophages at sites of future AMD and experimentally demonstrates that manipulating immunity may be a target for modulating the development of AMD.
has issue date	2013-03-07(xsd:dateTime)
bibo:doi	10.1155/2013/503725
bibo:pmid	23533946
has license	cc-by
sha1sum (hex)	d08ac6ac9dd268022b8cbe5cba116dd2bd12f757
schema:url	https://doi.org/10.1155/2013/503725
resource representing a document's title	Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration
has PubMed Central identifier	PMC3606733
has PubMed identifier	23533946
schema:publication	Int J Inflam
resource representing a document's body	covid:d08ac6ac9dd268022b8cbe5cba116dd2bd12f757#body_text
is schema:about of	named entity 'mice' named entity 'observed' named entity 'IPM' named entity 'immunized' named entity 'mice' named entity 'photoreceptor' named entity 'phenotype' named entity 'Age-Related Macular Degeneration' named entity 'Retina' named entity 'CONTROLS' named entity 'TIME' named entity 'PROVIDES' named entity 'SEGMENTS' named entity 'AGE-RELATED MACULAR DEGENERATION' named entity 'CHANGES' named entity 'CCR2' named entity 'YOUNG AGE' named entity 'EXAMINED' named entity 'MODEL' named entity 'RETINAL LESIONS' named entity 'MOUSE MODEL' named entity 'RETINA' named entity 'INFLAMMATION' named entity 'WORLD' named entity 'RETINA' named entity 'MICE' named entity 'ASSOCIATED' named entity 'INFILTRATING' named entity 'MACROPHAGES' named entity 'A MAJOR' named entity 'OVERT' named entity 'OUTER' named entity 'PRIOR TO' named entity 'DEPENDENT' named entity 'LIKE' named entity 'CAUSE' named entity 'OUTER' named entity 'INFILTRATION' named entity 'PHENOTYPE' named entity 'CELLS' named entity 'SITES' named entity 'DAMAGE' named entity 'MACROPHAGES' named entity 'MODEL OF' named entity 'AGE-RELATED MACULAR DEGENERATION' named entity 'IMMUNITY' named entity 'HERE' named entity 'IMMUNIZED' named entity 'NOT PRESENT' named entity 'DEGENERATIVE CHANGES' named entity 'POORLY DEFINED' named entity 'INCREASE' named entity 'OXIDATIVE DAMAGE' named entity 'AMD' named entity 'OUR' named entity 'LIPID PEROXIDATION' named entity 'IS A' named entity 'LESION' named entity 'PATHOLOGY' named entity 'FUTURE' named entity 'NUMBER OF'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software