About: Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7

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About: Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7 Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7
Creator	Bi, Yuhai Chen, Jianjun Chen, Yanyu Ding, Zhuang Fei, Yidong Li, Junjiao Li, Qingmei Liu, Xinxin Qian, Jing Stoeger, Tobias Tao, Zhi Wang, Xueli Xue, Cong Yin, Renfu Zhang, Pingze Li, Wang Li, Chen Faizal, Mohamed Liu, Ding Lugo-Villarino, Geanncarlo Fei, Tao Heidari, Mohammad Jansen, Christine
Source	Medline; PMC
abstract	Newcastle disease (ND), caused by infections with virulent strains of Newcastle disease virus (NDV), is one of the most important infectious disease affecting wild, peridomestic, and domestic birds worldwide. Vaccines constructed from live, low-virulence (lentogenic) viruses are the most accepted prevention and control strategies for combating ND in poultry across the globe. Avian macrophages are one of the first cell lines of defense against microbial infection, responding to signals in the microenvironment. Although macrophages are considered to be one of the main target cells for NDV infection in vivo, very little is known about the ability of NDV to infect chicken macrophages, and virulence mechanisms of NDV as well as the polarized activation patterns of macrophages and correlation with viral infection and replication. In the present study, a cell culture model (chicken bone marrow macrophage cell line HD11) and three different virulence and genotypes of NDV (including class II virulent NA-1, class II lentogenic LaSota, and class I lentogenic F55) were used to solve the above underlying questions. Our data indicated that all three NDV strains had similar replication rates during the early stages of infection. Virulent NDV titers were shown to increase compared to the other lentogenic strains, and this growth was associated with a strong upregulation of both pro-inflammatory M1-like markers/cytokines and anti-inflammatory M2-like markers/cytokines in chicken macrophages. Virulent NDV was found to block toll-like receptor (TLR) 7 expression, inducing higher expression of type I interferons in chicken macrophages at the late stage of viral infection. Only virulent NDV replication can be inhibited by pretreatment with TLR7 ligand. Overall, this study demonstrated that virulent NDV activates a M1-/M2-like mixed polarized activation of chicken macrophages by inhibition of TLR7, resulting in enhanced replication compared to lentogenic viruses.
has issue date	2018-04-04(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.00366
bibo:pmid	29670609
has license	cc-by
sha1sum (hex)	d088899449bf633659a0c6018571d0f6f7d58ec0
schema:url	https://doi.org/10.3389/fimmu.2018.00366
resource representing a document's title	Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7
has PubMed Central identifier	PMC5893744
has PubMed identifier	29670609
schema:publication	Front Immunol
resource representing a document's body	covid:d088899449bf633659a0c6018571d0f6f7d58ec0#body_text
is schema:about of	named entity 'microenvironment' named entity 'activation' named entity 'NDV' named entity 'type I interferons' named entity 'macrophages' named entity 'caused' named entity 'infection' named entity 'NDV' named entity 'data' named entity 'infection' named entity 'Avian' named entity 'bone marrow' named entity 'chicken' named entity 'Macrophages' named entity 'VIRULENT' named entity 'LATE STAGE' named entity 'UPREGULATION' named entity 'INFLAMMATORY' named entity 'USED' named entity 'NEWCASTLE DISEASE' named entity 'MACROPHAGES' named entity 'CORRELATION' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'MICROBIAL INFECTION' named entity 'GENOTYPES' named entity 'IN VIVO' named entity 'DEFENSE' named entity 'BIRDS' named entity 'AFFECTING' named entity 'ABOUT' covid:arg/d088899449bf633659a0c6018571d0f6f7d58ec0 named entity 'TLR7' named entity 'WORLDWIDE' named entity 'ACCEPTED' named entity 'UNDERLYING' named entity 'ABILITY' named entity 'ACROSS' named entity 'POULTRY' named entity 'STRAINS' named entity 'LIVE' named entity 'CONSIDERED' named entity 'INFECTIONS' named entity 'ENHANCED' named entity 'CHICKEN' named entity 'NEWCASTLE DISEASE VIRUS' named entity 'TARGET CELLS' named entity 'ACTIVATES' named entity 'EXPRESSION' named entity 'VERY LITTLE' named entity 'TYPE I INTERFERONS' named entity 'PRETREATMENT' named entity 'LOW' named entity 'MICROENVIRONMENT' named entity 'INHIBITED' named entity 'CELLS' named entity 'DUE TO' named entity 'REPLICATION' named entity 'ACTIVATION' named entity 'DIFFERENT'

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