About: Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics
Creator	Beullens, Monique Bollen, Mathieu Ferreira, Mónica Van Eynde, Aleyde
Source	Elsevier; Medline; PMC
abstract	Abstract Protein phosphatase 1 (PP1) catalyzes more than half of all phosphoserine/threonine dephosphorylation reactions in mammalian cells. In vivo PP1 does not exist as a free catalytic subunit but is always associated with at least one regulatory PP1-interacting protein (PIP) to generate a large set of distinct holoenzymes. Each PP1 complex controls the dephosphorylation of only a small subset of PP1 substrates. We screened the literature for genetically engineered mouse models and identified models for all PP1 isoforms and 104 PIPs. PP1 itself and at least 49 PIPs were connected to human disease-associated phenotypes. Additionally, phenotypes related to 17 PIPs were clearly linked to altered PP1 function, while such information was lacking for 32 other PIPs. We propose structural reverse genetics, which combines structural characterization of proteins with mouse genetics, to identify new PP1-related therapeutic targets. The available mouse models confirm the pleiotropic action of PP1 in health and diseases.
has issue date	2019-01-31(xsd:dateTime)
bibo:doi	10.1016/j.bbamcr.2018.07.019
bibo:pmid	30056088
has license	els-covid
sha1sum (hex)	d06c1c56443bbb298c2cdeabb60aad6bedf74d82
schema:url	https://doi.org/10.1016/j.bbamcr.2018.07.019
resource representing a document's title	Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics
has PubMed Central identifier	PMC7114192
has PubMed identifier	30056088
schema:publication	Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
resource representing a document's body	covid:d06c1c56443bbb298c2cdeabb60aad6bedf74d82#body_text
is schema:about of	named entity 'MOUSE GENETICS' named entity 'ASSOCIATED WITH' named entity 'BUT' named entity 'DISTINCT' named entity 'MODELS' named entity 'STRUCTURAL' named entity 'REACTIONS' named entity 'PP1' named entity 'FUNCTION' named entity 'MOUSE MODELS' named entity 'pleiotropic' named entity 'subunit' named entity 'genetics' named entity 'HOLOENZYMES' named entity 'LACKING' named entity 'SUBSET' named entity 'FUNCTIONS' covid:arg/d06c1c56443bbb298c2cdeabb60aad6bedf74d82 named entity 'AVAILABLE' named entity 'REGULATORY' named entity 'HALF' named entity 'MOUSE GENETICS' named entity 'PHOSPHOSERINE' named entity 'INTERACTING' named entity 'THERAPEUTIC' named entity 'STRUCTURAL CHARACTERIZATION' named entity 'ASSOCIATED' named entity 'TO IDENTIFY' named entity 'COMPLEX' named entity 'RELATED' named entity 'THERAPEUTIC' named entity 'INSIGHTS' named entity 'FREE' named entity 'SET' named entity 'NEW' named entity 'COMBINES' named entity 'DISEASES' named entity 'CATALYTIC' named entity 'EXIST' named entity 'LARGE' named entity 'INFORMATION' named entity 'MAMMALIAN' named entity 'LITERATURE' named entity 'CONFIRM' named entity 'ISOFORMS' named entity 'GENERATE' named entity 'IN VIVO' named entity 'HEALTH' named entity 'PHENOTYPES' named entity 'SUBUNIT' named entity '104' named entity 'DEPHOSPHORYLATION' named entity 'PROTEIN ' named entity 'POTENTIAL' named entity 'PROTEIN PHOSPHATASE 1' named entity 'IDENTIFIED' named entity 'MORE THAN' named entity 'PROTEIN PHOSPHATASE 1' named entity 'HUMAN DISEASE' named entity 'GENETICALLY ENGINEERED MOUSE' named entity 'TARGETS' named entity 'CELLS' named entity 'ACTION' named entity 'DOES NOT' named entity 'SMALL' named entity 'ALTERED' named entity 'PROTEINS' named entity 'REVERSE GENETICS' named entity 'PIPS' named entity 'structural' named entity 'genetics' named entity 'mouse models' named entity 'transgenic expression' named entity 'PLN' named entity 'severe acute respiratory syndrome' named entity 'analgesia' named entity 'PP1' named entity 'GADD34'

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