About: Decitabine: a historical review of the development of an epigenetic drug

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About: Decitabine: a historical review of the development of an epigenetic drug Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Decitabine: a historical review of the development of an epigenetic drug
Creator	De, Dick Wendy Van Overveld, Vos
Source	PMC
abstract	The development of decitabine from its synthesis in 1964 to the submission of a registration file has been described. Although the unique DNA-demethylating capacity of decitabine is known for a long time, its application is under continuing investigation. The use of decitabine in MDS, AML, CML, stem cell transplant, sickle cell anemia and thalassemia looks promising. The epigenetic dose seems lower than the cytotoxic dose. Whereas most drugs have matured after 40 years, decitabine is only at the beginning of a new development phase in epigenesis.
has issue date	2005-10-12(xsd:dateTime)
bibo:doi	10.1007/s00277-005-0008-x
bibo:pmid	16220311
has license	no-cc
sha1sum (hex)	d0683a9964f600d5b813079568679c6255864757
schema:url	https://doi.org/10.1007/s00277-005-0008-x
resource representing a document's title	Decitabine: a historical review of the development of an epigenetic drug
has PubMed Central identifier	PMC7103145
has PubMed identifier	16220311
schema:publication	Ann Hematol
resource representing a document's body	covid:d0683a9964f600d5b813079568679c6255864757#body_text
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