About: Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity
Creator	Shetty, Shishir Adams, David Lalor, Patricia
Source	Medline; PMC
abstract	Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do not simply form a barrier within the hepatic sinusoids but have vital physiological and immunological functions, including filtration, endocytosis, antigen presentation and leukocyte recruitment. Reflecting these multifunctional properties, LSECs display unique structural and phenotypic features that differentiate them from the capillary endothelium present within other organs. It is now clear that LSECs have a critical role in maintaining immune homeostasis within the liver and in mediating the immune response during acute and chronic liver injury. In this Review, we outline how LSECs influence the immune microenvironment within the liver and discuss their contribution to immune-mediated liver diseases and the complications of fibrosis and carcinogenesis.
has issue date	2018-05-29(xsd:dateTime)
bibo:doi	10.1038/s41575-018-0020-y
bibo:pmid	29844586
has license	no-cc
sha1sum (hex)	d00ad11498cde55994ae6de515bc1970ef108f75
schema:url	https://doi.org/10.1038/s41575-018-0020-y
resource representing a document's title	Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity
has PubMed Central identifier	PMC7096836
has PubMed identifier	29844586
schema:publication	Nat Rev Gastroenterol Hepatol
resource representing a document's body	covid:d00ad11498cde55994ae6de515bc1970ef108f75#body_text
is schema:about of	named entity 'fibrosis' named entity 'recruitment' named entity 'PARENCHYMAL HEPATIC CELL' named entity 'FIBROSIS' named entity 'SINUSOIDAL CAPILLARY' named entity 'HEPATIC SINUSOIDS' named entity 'BARRIER' named entity 'REFLECTING' named entity 'MEDIATING' named entity 'PROPERTIES' named entity 'ENDOCYTOSIS' named entity 'MICROENVIRONMENT' named entity 'DIFFERENTIATE' named entity 'CRITICAL' named entity 'ENDOTHELIAL CELLS' named entity 'DISPLAY' named entity 'LOW' named entity 'IMMUNE' named entity 'REVIEW' named entity 'LINE' named entity 'IMMUNE-MEDIATED' named entity 'STRUCTURAL' named entity 'CARCINOGENESIS' named entity 'CHANNELS' named entity 'FEATURES' named entity 'ACUTE' named entity 'FILTRATION' named entity 'VITAL' named entity 'HOW' named entity 'THEIR' named entity 'LIVER' named entity 'CAPILLARY ENDOTHELIUM' named entity 'THESE' named entity 'IMMUNOLOGICAL' named entity 'CLEAR' named entity 'UNIQUE' named entity 'HAVE' named entity 'LEUKOCYTE RECRUITMENT' named entity 'NON-' named entity 'DISCUSS' named entity 'OUTLINE' named entity 'CELL POPULATION' named entity 'PHYSIOLOGICAL' named entity 'SHEAR' named entity 'HOMEOSTASIS' named entity 'ROLE' named entity 'CHRONIC LIVER INJURY' named entity 'BUT' named entity 'FORM' named entity 'ABUNDANT' named entity 'COMPLICATIONS' named entity 'INFLUENCE' named entity 'LIVER DISEASES' named entity 'SINUSOIDAL' named entity 'MAINTAINING' named entity 'INCLUDING' named entity 'CONTRIBUTION' named entity 'IMMUNE RESPONSE' named entity 'FUNCTIONS' named entity 'ANTIGEN PRESENTATION' named entity 'ORGANS' named entity 'PRESENT' named entity 'DO NOT' named entity 'PHENOTYPIC' named entity 'shear' named entity 'hepatic sinusoids' named entity 'injury' named entity 'Liver' named entity 'microenvironment' named entity 'population' named entity 'carcinogenesis' named entity 'liver' named entity 'parenchymal' named entity 'immune response' named entity 'chronic liver' named entity 'capillary channels' named entity 'endocytosis' named entity 'liver' named entity 'liver diseases'

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