About: Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry

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About: Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry
Creator	María, · Cerrato, Enrico Marín, Francisco Núñez-Gil, Iván Romero, Rodolfo Trabattoni, Daniela Aparisi, Alvaro Bardají, Alfredo El-Battrawy, Ibrahim Estrada, Vicente Feltes, Gisela Fernández-Rozas, Inmaculada López-País, Javier Pepe, Martino Raposeiras-Roubin, Sergio Uribarri, Aitor Alex, · Antonio Fernández-Ortiz, · Becerra-Muñoz, M Carlos Macaya, · Castro-Mejía, F Fabrizio D'ascenzo, · Oscar, · Thamar Capel-Astrua, · Viana-Llamas, C Victor, ·
Source	Medline; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite its international aggressive extension, with a significant morbidity and mortality, the impact of renal function on its prognosis is uncertain. METHODS: Analysis from the international HOPE-Registry (NCT04334291). The objective was to evaluate the association between kidney failure severity on admission with the mortality of patients with SARS-CoV-2 infection. Patients were categorized in 3 groups according to the estimated glomerular filtration rate on admission (eGFR > 60 mL/min/1.73 m(2), eGFR 30–60 mL/min/1.73 m(2) and eGFR < 30 mL/min/1.73 m(2)). RESULTS: 758 patients were included: mean age was 66 ± 18 years, and 58.6% of patient were male. Only 8.5% of patients had a history of chronic kidney disease (CKD); however, 30% of patients had kidney dysfunction upon admission (eGFR < 60 mL/min/1.73 m(2)). These patients received less frequently pharmacological treatment with hydroxychloroquine or antivirals and had a greater number of complications such as sepsis (11.9% vs 26.4% vs 40.8%, p < 0.001) and respiratory failure (35.4% vs 72.2% vs 62.0%, p < 0.001) as well as a higher in-hospital mortality rate (eGFR > 60 vs eGFR 30-60 vs and eGFR < 30, 18.4% vs 56.5% vs 65.5%, p < 0.001). In multivariate analysis: age, hypertension, renal function, 0(2) saturation < 92% and lactate dehydrogenase elevation on admission independently predicted all-cause mortality. CONCLUSIONS: Renal failure on admission in patients with SARS-CoV-2 infection is frequent and is associated with a greater number of complications and in-hospital mortality. Our data comes from a multicenter registry and therefore does not allow to have a precise mortality risk assessment. More studies are needed to confirm these findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40620-020-00790-5) contains supplementary material, which is available to authorized users.
has issue date	2020-06-29(xsd:dateTime)
bibo:doi	10.1007/s40620-020-00790-5
bibo:pmid	32602006
has license	no-cc
sha1sum (hex)	cff9e74fb294d9e39c98b5d87e06bcbac7036422
schema:url	https://doi.org/10.1007/s40620-020-00790-5
resource representing a document's title	Impact of renal function on admission in COVID-19 patients: an analysis of the international HOPE COVID-19 (Health Outcome Predictive Evaluation for COVID 19) Registry
has PubMed Central identifier	PMC7322375
has PubMed identifier	32602006
schema:publication	J Nephrol
resource representing a document's body	covid:cff9e74fb294d9e39c98b5d87e06bcbac7036422#body_text
is schema:about of	named entity 'disease' named entity 'number' named entity 'antivirals' named entity 'Results' named entity 'greater' named entity 'patients' named entity 'SARS-CoV-2' named entity 'mortality' named entity 'independently' named entity 'admission' named entity '2F1' named entity 'RESPIRATORY FAILURE' named entity 'HYDROXYCHLOROQUINE' named entity 'DISEASE CAUSED BY SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2' named entity 'MORBIDITY AND MORTALITY' named entity 'INTERNATIONAL' named entity 'PATIENTS' named entity 'CORONAVIRUS DISEASE 2019' named entity 'SIGNIFICANT' named entity 'MULTIVARIATE ANALYSIS' named entity 'MALE' named entity 'DOES NOT' named entity '8.5' named entity 'HIGHER' named entity 'ANALYSIS' named entity 'CONFIRM' named entity 'INCLUDED' named entity '30%' named entity 'MIN' named entity 'KIDNEY DYSFUNCTION' named entity 'DATA' named entity 'METHODS' named entity 'confirm' named entity 'admission' named entity 'admission' named entity 'renal function' named entity 'comparison group' named entity 'cytokine storm' named entity 'infection' named entity 'dialysis' named entity 'eGFR' named entity 'univariate analysis' named entity 'AKI' named entity 'regression analysis' named entity 'eGFR' named entity 'downregulation' named entity 'prognosis' named entity 'eGFR' named entity 'coronavirus' named entity 'RAAS' named entity 'eGFR' named entity 'virus' named entity 'anticoagulants' named entity 'sepsis' named entity 'eGFR' named entity 'serum creatinine'

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