About: Interleukin-35 on B cell and T cell induction and regulation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interleukin-35 on B cell and T cell induction and regulation
Creator	He, Miao Nie, Jun Cheng, Lin Huang, Ai Jiang, Ke Wang, Jianjun
Source	Medline; PMC
abstract	Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of recombinant IL-35 (rIL-35) and IL-35 regulation role in various diseases. B-cell regulation expands the regulatory range of IL-35 and alters the view that IL-10 is the chief immune mechanism for Breg cells which secrete IL-35. IL-35 induces Breg cells, which then can induce Treg cells. IL-35 also plays an immunomodulatory role in the human body.
has issue date	2017-08-07(xsd:dateTime)
bibo:doi	10.1186/s12950-017-0164-5
bibo:pmid	28794689
has license	cc-by
sha1sum (hex)	cfb03431670da70ab0a1cac08df0d45d8f420ad2
schema:url	https://doi.org/10.1186/s12950-017-0164-5
resource representing a document's title	Interleukin-35 on B cell and T cell induction and regulation
has PubMed Central identifier	PMC5547520
has PubMed identifier	28794689
schema:publication	J Inflamm (Lond)
resource representing a document's body	covid:cfb03431670da70ab0a1cac08df0d45d8f420ad2#body_text
is schema:about of	named entity 'cells' named entity 'alters' named entity 'Breg' named entity 'transfer' named entity 'chief' named entity 'human body' named entity 'induces' named entity 'Interleukin' named entity 'DISEASES' named entity 'REVIEW' named entity 'INTERLEUKIN-35' named entity 'VIEW' named entity 'REGULATION' named entity 'REGULATORY' named entity 'B CELLS' named entity 'HUMAN BODY' named entity 'DOCUMENTS' named entity 'IL-35' named entity 'NEWLY DISCOVERED' named entity 'INDUCTION' named entity 'B CELL' named entity 'T CELL' named entity 'BREG' named entity 'THERAPEUTIC' named entity 'INDUCE' named entity 'RECOMBINANT' named entity 'FORMED' named entity 'EFFECT' named entity 'B-CELL' named entity 'IL-12' named entity 'TREG' named entity 'SECRETE' named entity 'DIMER' named entity 'ROLE' named entity 'REGULATORY B CELLS' named entity 'PLAYS' named entity 'STRUCTURE' named entity 'IS A' named entity 'INTERLEUKIN ' named entity 'VARIOUS' named entity 'CELLS' named entity 'FAMILY' named entity 'IL-10' named entity 'IMMUNOMODULATORY' named entity 'T CELLS' named entity 'REGULATION' named entity 'IMMUNE' named entity 'SIGNAL TRANSDUCTION' named entity 'RANGE' named entity 'MECHANISM' named entity 'ADOPTIVE TRANSFER' named entity 'SECRETION' named entity 'UNIQUE' named entity 'CYTOKINE ' named entity 'MEMBER OF' named entity 'diseases' named entity 'immune mechanism' named entity 'cells' named entity 'B cell' named entity 'human body' named entity 'IL-35' named entity 'Interleukin' named entity 'IL-35' named entity 'immunomodulatory' named entity 'immune mechanism' named entity 'IL-10' named entity 'protein' named entity 'IL-35' named entity 'down-regulation' named entity 'macrophages' named entity 'lymphoma' named entity 'heterodimer' named entity 'transcription' named entity 'microenvironments' named entity 'TGF-β' named entity 'immune response'

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